Basic information
- Name:
Gliclazide
- CAS No.:
21187-98-4
- Molecular Structure:
- Formula:
- C15H21N3O3S
- Synonyms:
- Urea,1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)- (8CI);Cyclopenta[c]pyrrole, benzenesulfonamide deriv.;1-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea;Diabezidum;Diabyl;Diamicron;Diaprel;Glimicron;Glinormax;Glyzide;N-(4-Methylbenzenesulfonyl)-N'-[3-azabicyclo(3,3,0)oct-3-yl]urea;S1702;S 852;SE 1702;Benzenesulfonamide,N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-;
Other Products
- Titanium DioxideCarbon black Glutathione Adenosine Cable pulling lubricant
- 52482-62-98-butan-2-yl-1,3,7-trimethyl-purine-2,6-dione
- 5731-10-24'-Fluorobiphenyl-4-carboxylic acid
- 10128-91-3Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
- 39802-78-32'-Chlorobiphenyl-4-carbaldehyde
- 111174-59-5Alcohols, C8-16, reaction products with phosphorus oxide (P2O5)
- 7554-28-1D-(+)-Malic acid diethyl ester
- 7682-14-6N-ACETYL-DL-2-AMINO-N-BUTYRIC ACID
- 114176-54-4ethyl (NZ)-N-[[2-(6-chloropyrazin-2-yl)hydrazinyl]methylidene]carbamate
- 15833-00-82-(2-Aminophenyl)propan-2-ol
- 1550-27-21-chloro-2-nitro-4-(trifluoromethylsulfonyl)benzene
- 76-46-02-(2-Hex-1-ynylcyclohexyl)isoindole-1,3-Dione
- 31738-10-06,16B-DIMETHYL-20-OXO-11B,17A,21-TRIOL-2-(P-FLUOROPHENYL)PREGNA-4,6-DIENO-(3,2-
- 697-37-01-prop-1-ynylcyclohexan-1-ol
- 175135-19-05-morpholin-4-yl-2-nitro-phenolate
- 22255-10-3[(3S,6aR,6bS,8aR,11R,12S,12aS,14aS,14bS)-4,4,6a,6b,8a,11,12,14b-octamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-yl] hexadecanoate
Home >
Hot Product_List > Gliclazide
- Refine Suppliers
- Do you want your product ranking ahead? Know what is 'Top Seller'!
- Supplier Location:
China (Mainland)(60)
India(8)
Italy(3)
United States(3)
Brazil(1)
Korea(1)
Switzerland(1)
- Business Type:
- Importer/Exporter(51)Lab/Research institutions(6)Manufacturers(1)
- Certificates:
- ISO(3)Production License(1)
Please post your buying leads,so that our qualified suppliers
will soon contact you!
*Required Fields
Chemistry
.jpg)
IUPAC Name: 1-(3,3a,4,5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
Empirical Formula: C15H21N3O3S
Molecular Weight: 323.4105
Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
InChI: InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
InChIKey: BOVGTQGAOIONJV-UHFFFAOYSA-N
EINECS: 244-260-5
Product Categories: Pharmaceutical; Active Pharmaceutical Ingredients; APIs; Intermediates & Fine Chemicals; Pharmaceuticals; API's; Potassium channel
Index of Refraction: 1.623
Molar Refractivity: 84.41 cm3
Molar Volume: 239.2 cm3
Surface Tension: 60.4 dyne/cm
Density: 1.35 g/cm3
Appearance: White Cyrstalline Solid
Melting Point: 163-169 °C(lit.)
solubility: methylene chloride: soluble
Classification Code of Gliclazide (CAS NO.21187-98-4): Drug / Therapeutic Agent; Human Data; Hypoglycemic agents; Reproductive Effect
Uses
Gliclazide is used for control of hyperglycemia in gliclazide-responsive diabetes mellitus of stable, mild, non-ketosis prone, maturity-onset or adult type. It is used when diabetes cannot be controlled by proper dietary management and exercise or when insulin therapy is not appropriate.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 1gm/kg (1000mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 81, 1982. | |
| mouse | LD50 | intravenous | 295mg/kg (295mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980. |
| mouse | LD50 | oral | 3gm/kg (3000mg/kg) | Indian Drugs. Vol. 15, Pg. 161, 1978. | |
| mouse | LD50 | subcutaneous | 1034mg/kg (1034mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980. |
| rat | LD50 | intravenous | 382mg/kg (382mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980. |
| rat | LD50 | oral | 3gm/kg (3000mg/kg) | Indian Drugs. Vol. 15, Pg. 161, 1978. | |
| rat | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980. | |
| women | TDLo | oral | 9600ug/kg/24D (9.6mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | Internal Medicine. Vol. 33, Pg. 163, 1994. |
Safety Profile
Hazard Codes:
Xn,
Xi
Risk Statements:21-36/38-46-62-63
R21:Harmful in contact with skin
R36/38:Irritating to eyes and skin
R46:May cause heritable genetic damage
R62:Possible risk of impaired fertility
R63:Possible risk of harm to the unborn child
Safety Statements:25-26-36/37-53
S25:Avoid contact with eyes
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37:Wear suitable protective clothing and gloves
S53:Avoid exposure - obtain special instruction before use
WGK Germany:2
RTECS:YT4500000
Xn,XiRisk Statements:21-36/38-46-62-63
R21:Harmful in contact with skin
R36/38:Irritating to eyes and skin
R46:May cause heritable genetic damage
R62:Possible risk of impaired fertility
R63:Possible risk of harm to the unborn child
Safety Statements:25-26-36/37-53
S25:Avoid contact with eyes
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37:Wear suitable protective clothing and gloves
S53:Avoid exposure - obtain special instruction before use
WGK Germany:2
RTECS:YT4500000
Specification
Gliclazide (CAS NO.21187-98-4), its Synonyms are 1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea ; 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea ; Benzenesulfonamide, N-(((hexahydrocyclopenta(c)pyrrol-2(1H)-yl)amino)carbonyl)-4-methyl- ; Diamicron ; Glimicron ; N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea ; Nordialex .
- About us
- |
- Payment
- |
- Contact us
- |
- Links
- |
- Help Center
- |
- Disclaimer
- |
- Add to favorite
- | SiteMap
- |
- Product SiteMap
- |
- Manufacturers
- |
- Suppliers
©2008 LookChem.com,License:ICP NO.：Zhejiang10014259
[Hangzhou]86-571-85317600,85317603,85317620