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Gludiase
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  • Name Gludiase
  • EINECSN/A
  • CAS No. 1492-02-0
  • Density1.344g/cm3
  • PSA108.57000
  • LogP3.79020
  • SolubilityN/A
  • Melting Point163°
  • FormulaC12H15 N3 O2 S2
  • Boiling Point449.4°Cat760mmHg
  • Molecular Weight297.402
  • Flash Point225.6°C
  • Transport InformationN/A
  • AppearanceN/A
  • SafetyPoison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of SOx and NOx.
  • Risk CodesN/A
  • Molecular Structure
    Molecular Structure of 1492-02-0 (glybuzole)
  • Hazard SymbolsN/A
  • SynonymsN/A
  • Article Data3

Gludiase Chemical Properties

IUPAC Name: N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
Synonyms of Gludiase (CAS NO.1492-02-0) : Benzenesulfonamide, N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]- ; N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide ; Sulfamidothiodiazol
InChI:InChI=1/C12H15N3O2S2/c1-12(2,3)10-13-14-11(18-10)15-19(16,17)9-7-5-4-6-8-9/h4-8H,1-3H3,(H,14,15) 
CAS NO:1492-02-0
Molecular Formula:C12H15N3O2S2                                         
Molecular Weight :297.3964                                                           
Molecular Structure :
EINECS: 216-081-2
Index of Refraction:1.605     
Surface Tension: 60.2 dyne/cm 
Density: 1.344 g/cm3 
Flash Point: 225.6 °C 
Enthalpy of Vaporization: 70.8 kJ/mol 
Boiling Point: 449.4 °C at 760 mmHg 
Vapour Pressure: 2.88E-08 mmHg at 25°C 

Gludiase Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 235mg/kg (235mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
mouse LD50 intravenous 193mg/kg (193mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
mouse LD50 oral 550mg/kg (550mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

ENDOCRINE: HYPOGLYCEMIA		 Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 131, 1969.
mouse LD50 subcutaneous 248mg/kg (248mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rabbit LD50 intraperitoneal 300mg/kg (300mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rabbit LD50 intravenous 118mg/kg (118mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rabbit LD50 oral 967mg/kg (967mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rat LD50 intraperitoneal 219mg/kg (219mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rat LD50 oral 500mg/kg (500mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rat LD50 subcutaneous 310mg/kg (310mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.

Gludiase Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When Gludiase (CAS NO.1492-02-0) is heated to decomposition, it emits toxic fumes of SOx and NOx.

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