Basic information
- Name:
Glutathione
- CAS No.:
70-18-8
- Molecular Structure:
- Formula:
- C10H17N3O6S
- Molecular Weight:
- 307.36
- Synonyms:
- Glutathione(8CI);Glycine, N-(N-L-g-glutamyl-L-cysteinyl)-;Copren;Glutathion;Glutathione-SH;Glutide;Glutinal;Isethion;L-Glutathione;N-(N-L-g-Glutamyl-L-cysteinyl)glycine;Tathione;g-Glutamylcysteinylglycine;g-L-Glutamyl-L-cysteinylglycine;Glycine, L-g-glutamyl-L-cysteinyl-;GSH;L-Glutathione Reduced;
- EINECS:
- 200-725-4
- Density:
- 1.441 g/cm3
- Melting Point:
- 192-195 °C (dec.)(lit.)
- Boiling Point:
- 754.492 °C at 760 mmHg
- Flash Point:
- 410.102 °C
- Solubility:
- Soluble in water
- Appearance:
- White cryst. powder
- Hazard Symbols:
Xi- Risk Codes:
- 68-36/37/38
- Safety Description:
- 24/25-36/37/39-27-26 Details
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Chemistry
Molecular Structure:
.jpg)
IUPAC Name: (2S)-2-Amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
Molecular Formula: C10H17N3O6S
Molecular Weight: 307.32 g/mol
EINECS: 200-725-4
Classification Code: Mutation data; Reproductive Effect
Stability: Stable. Incompatible with strong oxidizing agents.
alpha: -16.5 °(c=2, H2O)
refractive index: -17 ° (C=2, H2O)
storage temp.: 2-8 °C
solubility: H2O: 50 mg/mL
Water Solubility: soluble
Melting Point: 192-195 °C (dec.)(lit.)
Index of Refraction: 1.571
Molar Refractivity: 70.1 cm3
Molar Volume: 213.2 cm3
Surface Tension: 69.3 dyne/cm
Density: 1.441 g/cm3
Flash Point: 410.1 °C
Enthalpy of Vaporization: 119.62 kJ/mol
Boiling Point: 754.5 °C at 760 mmHg
Vapour Pressure of GSH (CAS NO.70-18-8): 6.45E-25 mmHg at 25 °C
Uses
GSH (CAS NO.70-18-8) is a biological and chemical reagents, detoxification drugs which is mainly used for poisoning such as heavy metals, acrylonitrile, fluoride, carbon monoxide and organic solvents. Glutathione can also decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 4gm/kg (4000mg/kg) | "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Suppl Exporters' Assoc., 1968Vol. -, Pg. 97, 1968. | |
| mouse | LD50 | intraperitoneal | 4020mg/kg (4020mg/kg) | "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972. | |
| mouse | LD50 | intravenous | 2238mg/kg (2238mg/kg) | Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985. | |
| mouse | LD50 | oral | 5gm/kg (5000mg/kg) | "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972. | |
| mouse | LD50 | subcutaneous | 5gm/kg (5000mg/kg) | "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972. | |
| rabbit | LD50 | intravenous | > 2gm/kg (2000mg/kg) | Biochemical Journal. Vol. 41, Pg. 325, 1947 |
Consensus Reports
EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.
Safety Profile
Moderately toxic by intravenous route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Hazard Codes: 
Xi
Risk Statements: 68-36/37/38
R68: Possible risk of irreversible effects.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36/37/39-27-26
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S27: Take off immediately all contaminated clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 2
RTECS: MC0556000
Specification
GSH (CAS NO.70-18-8), its Synonyms are Glutathione ; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)- ; N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine ; Copren ; Deltathione ; Glutide ; Glutinal ; Glutathione ; Isethion ; L-Glutathione ; gamma-L-Glutamyl-L-cysteinylglycine ; gamma-L-Glutamylcysteinylglycine ; Glycine, L-gamma-glutamyl-L-cysteinyl- . It is white powder.