- Glycolic acid
- Glycolic acid, calcium salt
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Cas Database |
| Name |
Glycolic acid |
EINECS | 201-180-5 |
| CAS No. | 79-14-1 | Density | 1.416 g/cm3 |
| PSA | 57.53000 | LogP | -0.93670 |
| Solubility | H2O: 0.1 g/mL, clear | Melting Point |
75-80 °C(lit.) |
| Formula | C2H4O3 | Boiling Point | 265.6 °C at 760 mmHg |
| Molecular Weight | 76.052 | Flash Point | 128.7 °C |
| Transport Information | N/A | Appearance | Light yellow to amber liquid |
| Safety | 26-36/37/39-45-23 | Risk Codes | 34-22 |
| Molecular Structure |
|
Hazard Symbols |
 C
|
| Synonyms |
Aceticacid, hydroxy- (9CI);Glycolic acid (7CI,8CI);2-Hydroxyacetic acid;2-Hydroxyethanoic acid;GlyPure;GlyPure 70;GlyPure 99;Glycocide;Hydroxyaceticacid;Hydroxyethanoic acid;NSC 166;a-Hydroxyacetic acid; |
Article Data | 660 |
Glycolic acid Synthetic route
| Conditions | Yield |
|---|---|
| With sodium chlorite; dimethyl sulfoxide In aq. phosphate buffer at 0 - 20℃; pH=4; | 100% |
| With 5 % platinum on carbon In water at 80℃; under 7500.75 Torr; for 6h; Temperature; Time; Reagent/catalyst; Autoclave; | 78% |
| With oxygen In water at 180℃; under 3750.38 Torr; for 1h; Autoclave; | 50% |
| Conditions | Yield |
|---|---|
| With water at 25℃; | A 100% B 100% |
| With water-d2 at 25℃; Rate constant; Kinetics; half life; reactions of derivatives under var. conditions; | A 100% B 100% |
| Conditions | Yield |
|---|---|
| With water at 95 - 97℃; under 760.051 Torr; for 2h; Reactive distillation; | 100% |
| With water; Candida rugosa lipase In aq. phosphate buffer at 45℃; for 30h; pH=7.2; Enzymatic reaction; | |
| With water In methanol at 100℃; |
| Conditions | Yield |
|---|---|
| With trifluorormethanesulfonic acid; acetic acid at 140℃; under 13689.1 - 52476.2 Torr; for 4h; Catalytic behavior; Pressure; Temperature; Time; Reagent/catalyst; Concentration; Autoclave; | 99.9% |
| With trifluorormethanesulfonic acid; acetic acid at 140℃; under 13689.1 - 52476.2 Torr; for 4h; Catalytic behavior; Pressure; Temperature; Time; Reagent/catalyst; Concentration; Autoclave; | 99.9% |
| With trifluorormethanesulfonic acid; acetic acid at 140℃; under 13689.1 - 52476.2 Torr; for 4h; Catalytic behavior; Pressure; Temperature; Time; Reagent/catalyst; Concentration; Autoclave; | 99.9% |
| Conditions | Yield |
|---|---|
| Stage #1: ethylene glycol With Rh(OTf)(trop2NH)(PPh3); water; cyclohexanone; sodium hydroxide at 20℃; for 2h; Inert atmosphere; Stage #2: With hydrogenchloride In water Inert atmosphere; | 99% |
| Wird durch verschiedene Essigbakterien; | |
| With ruthenium trichloride; N-Bromosuccinimide; perchloric acid; mercury(II) diacetate; acetic acid In water Thermodynamic data; Mechanism; Kinetics; ΔE(excit.), ΔS(excit.), ΔH(excit.), and ΔF(excit.); |
- 35249-89-9
glycolic acid ammonium salt
- 79-14-1
glycolic Acid
| Conditions | Yield |
|---|---|
| With water | 98% |
| With sulfuric acid In water; 4-methyl-2-pentanone; kerosene at 25 - 75℃; for 0.5 - 1h; pH=2 - 3; Purification / work up; | |
| With sulfuric acid In water; toluene at 25 - 75℃; for 0.5h; pH=2 - 3; Purification / work up; |
- 131543-46-9
Glyoxal
- 79-14-1
glycolic Acid
| Conditions | Yield |
|---|---|
| With aluminum trihydroxide; water at 165℃; for 3h; Mechanism; | 92% |
| With water at 99.84℃; for 18h; Catalytic behavior; Reagent/catalyst; Temperature; Time; Sealed tube; Green chemistry; | 91% |
| With alkali |
| Conditions | Yield |
|---|---|
| With sulfuric acid; water at 105 - 110℃; for 6h; Temperature; | 92% |
| With water; microbial enzyme at 40℃; for 12h; Product distribution / selectivity; | 10 - 99 %Chromat. |
| Stage #1: glycolonitrile With sulfuric acid In water for 2191.5h; pH=3; Stage #2: With sodium hydroxide pH=7; Stage #3: With water; microbial enzyme at 40℃; for 12h; Product distribution / selectivity; | 99 %Chromat. |
| With nitrilase from Hoeflea phototrophica DFL-43; water In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 0.166667h; pH=8; Enzymatic reaction; |
| Conditions | Yield |
|---|---|
| With oxygen In water at 60℃; Catalytic behavior; Reagent/catalyst; Autoclave; chemoselective reaction; | A 8.9% B 89.9% C 6.8% |
| With oxygen In water at 80℃; under 7500.75 Torr; for 2h; pH=6.7; Reagent/catalyst; Autoclave; | |
| With oxygen In water at 60℃; under 3750.38 Torr; for 24h; Catalytic behavior; Kinetics; Reagent/catalyst; Time; High pressure; | A 7.8 %Chromat. B 55.4 %Chromat. C 7.7 %Chromat. |
- 30379-58-9
benzyl glycolate
- 79-14-1
glycolic Acid
| Conditions | Yield |
|---|---|
| With hydrogen Hydrogenolysis; | 88% |
Glycolic acid Chemical Properties
Product Name: Glycolic acid (CAS NO.79-14-1)
Molecular Formula: C2H4O3
Molecular Weight: 76.05g/mol
Mol File: 79-14-1.mol
EINECS: 201-180-5
Appearance: colourless crystalline solid
Melting Point: 75-80 °C(lit.)
Boiling point: 265.6 °C at 760 mmHg
Flash Point: 128.7 °C
Density: 1.416 g/cm3
Refractive index: n20/D 1.424
Water Solubility: SOLUBLE
Sensitive: Hygroscopic
Stability: Stable. Incompatible with bases, oxidizing agents and reducing agents
Index of Refraction: 1.449
Molar Refractivity: 14.41 cm3
Molar Volume: 53.6 cm3
Surface Tension: 61.3 dyne/cm
Enthalpy of Vaporization: 58.47 kJ/mol
Vapour Pressure: 0.00125 mmHg at 25°C
XLogP3-AA: -1.1
H-Bond Donor: 2
H-Bond Acceptor: 3
Structure Descriptors of Glycolic acid (CAS NO.79-14-1):
IUPAC Name: 2-hydroxyacetic acid
Canonical SMILES: C(C(=O)O)O
InChI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
InChIKey: AEMRFAOFKBGASW-UHFFFAOYSA-N
Product Categories: Pharmaceutical Intermediates; Roxatidine Acetate; omega-Hydroxycarboxylic Acids; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides; Hydroxycarboxylic Acids (for High-Performance Polymer Research); Functional Materials; Reagent for High-Performance Polymer Research; Cosmetic Ingredients & Chemicals
Glycolic acid Uses
Glycolic acid (CAS NO.79-14-1) can be used in various skin-care products.Due to its excellent capability to penetrate skin.
Glycolic acid is also a useful intermediate for organic synthesis, in a range of reactions including: oxidation-reduction, esterification and long chain polymerization. It is also used as a monomer in the preparation of polyglycolic acid and other biocompatible copolymers. Glycolic acid is often included into emulsion polymers, solvents and additives for ink and paint in order to improve flow properties and impart gloss.Other uses :in the textile industry as a dyeing and tanning agent, in food processing as a flavoring agent and as a preservative.
Glycolic acid Production
Glycolic acid (CAS NO.79-14-1) is prepared by the reaction of chloroacetic acid with sodium hydroxide followed by re-acidification as follows:
ClCH2CO2H + NaOH → HOCH2CO2H + NaCl
In this way, a few million kilograms are produced annually. Other methods, include hydrogenation of oxalic acid and the hydrolysis of the cyanohydrin derived from formaldehyde.but not apparently in use. Glycolic acid can be isolated from natural sources, such as sugar beets, sugarcane, canteloupe, pineapple, and unripe grapes.
Glycolic acid,we can also using an enzymatic biochemical process,compared to traditional chemical synthesis,it produces fewer impurities , requires less energy in production and produces less co-product.
Glycolic acid Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intravenous | 1gm/kg (1000mg/kg) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 656, 1986. | |
| guinea pig | LD50 | oral | 1920mg/kg (1920mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. |
| rat | LC50 | inhalation | 7100ug/m3/4H (7.1mg/m3) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Inhalation Toxicology. Vol. 9, Pg. 435, 1997. |
| rat | LD50 | oral | 1950mg/kg (1950mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. |
Glycolic acid Consensus Reports
Reported in EPA TSCA Inventory.
Glycolic acid Safety Profile
Moderately toxic by ingestion. A severe eye irritant. A skin and mucous membrane irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Glycolic acid (CAS NO.79-14-1):
Hazard Codes: C
Risk Statements: 34-22
R34: Causes burns.
R22: Harmful if swallowed.
Safety Statements: 26-36/37/39-45-23
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S23: Do not breathe vapour.
RIDADR: UN 3265 8/PG 3
WGK Germany: 1
RTECS: MC5250000
HazardClass: 8
PackingGroup: II
Glycolic acid Specification
Glycolic acid , its CAS NO. is 79-14-1, the synonyms are 2-Hydroxyacetic acid ; Acetic acid, hydroxy- ; EPA Pesticide Chemical Code 000101 ; Glycollic acid ; Hydroxyacetic acid ; Hydroxyethanoic acid ; Kyselina glykolova ; Kyselina hydroxyoctova .
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