Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Guaifenesin

Related Products

Hot Products

Basic Information post buying leads Suppliers
Name

Guaifenesin

EINECS 202-222-5
CAS No. 93-14-1 Density 1.195 g/cm3
Solubility 5 g/100 mL (25 °C) in water Melting Point 77-81 °C
Formula C10H14O4 Boiling Point 356.8 °C at 760 mmHg
Molecular Weight 198.24 Flash Point 169.6 °C
Transport Information Appearance White Solid
Safety 26-36 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 93-14-1 (Guaifenesin) Hazard Symbols HarmfulXn
Synonyms

1,2-Propanediol,3-(o-methoxyphenoxy)- (6CI,8CI);1,2-Dihydroxy-3-(2-methoxyphenoxy)propane;2-G;3-(2-Methoxyphenoxy)-1,2-propanediol;3-(o-Methoxyphenoxy)-1,2-propanediol;Actifed C;Aeronesin;Amonidren;Aresol;Calmipan;Colrex Expectorant;Creson;Dilyn;Equicol;Glycerin guaiacolate;Glycerol guaiacolate;Glycerol a-(2-methoxyphenyl)ether;Glycerol a-(o-methoxyphenyl)ether;Glycerol a-guaiacyl ether;Glyceryl guaiacolether;Glyceryl guaiacolate;Glyceryl guaiacolate ether;Glyceryl guaiacylether;Glycerylguaiacol;Glycodex;Glycotuss;Guaiacol glycerin ether;Guaiacolglycerol ether;Guaiacol glyceryl ether;Guaiacuran;Guaiacurane;Guaiacylglyceryl ether;Guaiamar;Guaianesin;

 

Guaifenesin Chemical Properties

IUPAC Name: 3-(2-Methoxyphenoxy)propane-1,2-diol
Synonyms of Guaifenesin (CAS NO.93-14-1): (+-)-3-(o-Methoxyphenoxy)-1,2-propanediol ; 1,2,3-Propanetriol, ether with 2-methoxyphenol ;1,2-Propanediol, 3-(2-methoxyphenoxy)- ; 3-(2-Methoxyphenoxy)-1,2-propanediol ; Aether glycerinoguaiacolicus
CAS NO: 93-14-1
Molecular Formula: C10H14O4
Molecular Weight: 198.22
Molecular Structure:
EINECS: 202-222-5
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 7
Polar Surface Area: 36.92 Å2
Index of Refraction: 1.538
Molar Refractivity: 51.9 cm3
Molar Volume: 165.8 cm3
Surface Tension: 45.6 dyne/cm
Density: 1.195 g/cm3
Flash Point: 169.6 °C
Enthalpy of Vaporization: 63.53 kJ/mol
Boiling Point: 356.8 °C at 760 mmHg
Vapour Pressure: 1.04E-05 mmHg at 25°C 
Melting Point: 77-81 °C
Water Solubility: 5 g/100 mL (25 °C)
Appearance: White Solid
Product Categories og Guaifenesin (CAS NO.93-14-1): Benzhydrols, Benzyl & Special Alcohols;Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;API's

Guaifenesin History

There are similar medicines derived from the guaiac tree were in use as a generic remedy by Native Americans when explorers reached North America in the 1500s. Guaifenesin was first approved by the Food and Drug Administration  in 1952.Guaifenesin is sold as pills or syrups under many brand names. It is also included in many other over-the-counter cough and cold remedy combinations

Guaifenesin Uses

 Guaifenesin (CAS NO.93-14-1) is mainly used in the treatment of coughing, but the drug has numerous other uses, including medical, veterinary, and personal.

Guaifenesin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 335mg/kg (335mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 688, 1958.
mouse LD50 intramuscular 2210mg/kg (2210mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 429, 1974.
mouse LD50 intraperitoneal 495mg/kg (495mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 398, 1972.
mouse LD50 intravenous 400mg/kg (400mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 429, 1974.
mouse LD50 oral 690mg/kg (690mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 398, 1972.
mouse LD50 subcutaneous 800mg/kg (800mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 1355, 1965.
rabbit LD50 oral 2553mg/kg (2553mg/kg)   Applied Therapeutics. Vol. 9, Pg. 55, 1967.
rat LD50 intramuscular 4gm/kg (4000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 429, 1974.
rat LD50 intraperitoneal 1gm/kg (1000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 191, Pg. 147, 1971.
rat LD50 intravenous 360mg/kg (360mg/kg) BEHAVIORAL: ATAXIA

KIDNEY, URETER, AND BLADDER: HEMATURIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 323, 1954.
rat LD50 oral 1510mg/kg (1510mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Pharmacological Research Communications. Vol. 1, Pg. 413, 1969.
rat LD50 subcutaneous 2550mg/kg (2550mg/kg)   Drugs in Japan Vol. 6, Pg. 210, 1982.

Guaifenesin Safety Profile

Safety Information about Guaifenesin (CAS NO.93-14-1):
Hazard Codes: HarmfulXn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 1
RTECS: TY8400000
Hazard Note: Harmful
Guaifenesin has side effect if consumption in above-normal quantities.May be cause nausea, vomiting, and the formation of kidney stones of URIC ACID.

Guaifenesin Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam .
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields