Basic information
- Name:
Histamine
- CAS No.:
51-45-6
- Molecular Structure:
- Formula:
- C5H9N3
- Synonyms:
- 1H-Imidazole-4-ethanamine(9CI);Histamine (8CI);2-(1H-Imidazol-4-yl)ethanamine;2-(1H-Imidazol-5-yl)ethanamine;2-(3H-Imidazol-4-yl)ethylamine;2-(4-Imidazolyl)ethanamine;4-(2-Aminoethyl)imidazole;5-Imidazoleethylamine;Eramin;Ergamine;Ergotidine;Imidazole-4-ethylamine;NSC 33792;b-Imidazolyl-4-ethylamine;
Other Products
- Titanium DioxideCarbon black Glutathione Adenosine Cable pulling lubricant
- 52482-62-98-butan-2-yl-1,3,7-trimethyl-purine-2,6-dione
- 5731-10-24'-Fluorobiphenyl-4-carboxylic acid
- 10128-91-3Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
- 39802-78-32'-Chlorobiphenyl-4-carbaldehyde
- 111174-59-5Alcohols, C8-16, reaction products with phosphorus oxide (P2O5)
- 7554-28-1D-(+)-Malic acid diethyl ester
- 7682-14-6N-ACETYL-DL-2-AMINO-N-BUTYRIC ACID
- 114176-54-4ethyl (NZ)-N-[[2-(6-chloropyrazin-2-yl)hydrazinyl]methylidene]carbamate
- 15833-00-82-(2-Aminophenyl)propan-2-ol
- 1550-27-21-chloro-2-nitro-4-(trifluoromethylsulfonyl)benzene
- 76-46-02-(2-Hex-1-ynylcyclohexyl)isoindole-1,3-Dione
- 31738-10-06,16B-DIMETHYL-20-OXO-11B,17A,21-TRIOL-2-(P-FLUOROPHENYL)PREGNA-4,6-DIENO-(3,2-
- 697-37-01-prop-1-ynylcyclohexan-1-ol
- 175135-19-05-morpholin-4-yl-2-nitro-phenolate
- 22255-10-3[(3S,6aR,6bS,8aR,11R,12S,12aS,14aS,14bS)-4,4,6a,6b,8a,11,12,14b-octamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-yl] hexadecanoate
- Refine Suppliers
- Do you want your product ranking ahead? Know what is 'Top Seller'!
- Supplier Location:
China (Mainland)(14)
Switzerland(1)
- Business Type:
- Importer/Exporter(11)Lab/Research institutions(1)
- Certificates:
- ISO(1)Production License(0)
Please post your buying leads,so that our qualified suppliers
will soon contact you!
*Required Fields
Chemistry
Molecular Structure:
.png)
Molecular Formula: C5H9N3
Molecular Weight: 111.1451
IUPAC Name: 2-(1H-Imidazol-5-yl)ethanamine
Synonyms of Histamine (CAS NO.51-45-6): Histamine [USAN] ; 1H-Imidazole-4-ethanamine ; 2-(4-Imidazolyl)ethylamine ; 4-(2-Aminoethyl)-1H-imidazole ; 5-Imidazoleethylamine ; CCRIS 6535 ; EINECS 200-100-6 ; Eramin ; Ergamine ; Ergotidine ; Ethylamine, 2-imidazol-4-yl- ; Free histamine ; HSDB 3338 ; Imidazole, 4-(2-aminoethyl)- ; Imidazole-4-ethylamine ; Istamina ; Istamina [Italian] ; NSC 33792 ; Theramine ; UNII-820484N8I3 ; beta-Aminoethylglyoxaline ; beta-Aminoethylimidazole ; beta-Imidazolyl-4-ethylamine ; 1H-Imidazole-5-ethanamine ; 2-Imidazol-4-ylethylamine
CAS NO: 51-45-6
Classification Code: Histamine Agents ; Histamine Agonists ; Mutation data ; Natural Product ; Neurotransmitter Agents ; Reproductive Effect
Melting point: 83-84 °C
Index of Refraction: 1.567
Molar Refractivity: 31.86 cm3
Molar Volume: 97.4 cm3
Surface Tension: 56 dyne/cm
Density: 1.14 g/cm3
Flash Point: 180.3 °C
Enthalpy of Vaporization: 57.36 kJ/mol
Boiling Point: 331 °C at 760 mmHg
Vapour Pressure: 0.00016 mmHg at 25 °C
Production
Histamine (CAS NO.51-45-6) is derived from the decarboxylation of the amino acid histidine, a reaction catalyzed by the enzyme L-histidine decarboxylase.
.png)
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | subcutaneous | 34mg/kg (34mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937. | |
| dog | LD50 | intravenous | 7mg/kg (7mg/kg) | CARDIAC: OTHER CHANGES | Indian Veterinary Journal. Vol. 57, Pg. 31, 1980. |
| dog | LDLo | subcutaneous | 28500ug/kg (28.5mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. |
| frog | LDLo | subcutaneous | 1700mg/kg (1700mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. | |
| guinea pig | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 736, 1948. | |
| guinea pig | LD50 | intravenous | 180ug/kg (0.18mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 45, 1949. | |
| guinea pig | LDLo | oral | 200mg/kg (200mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. |
| guinea pig | LDLo | subcutaneous | 8mg/kg (8mg/kg) | Farmaco, Edizione Scientifica. Vol. 9, Pg. 379, 1954. | |
| monkey | LDLo | intravenous | 50mg/kg (50mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. | |
| mouse | LD50 | intraperitoneal | 725mg/kg (725mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 17, Pg. 137, 1961. | |
| mouse | LD50 | intravenous | 385mg/kg (385mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979. |
| mouse | LD50 | oral | 220mg/kg (220mg/kg) | Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991. | |
| mouse | LD50 | subcutaneous | 2500mg/kg (2500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979. |
| rabbit | LDLo | intravenous | 2mg/kg (2mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 784, 1948. | |
| rabbit | LDLo | subcutaneous | 12mg/kg (12mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. |
| rat | LD50 | intravenous | 630mg/kg (630mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979. |
| rat | LDLo | subcutaneous | 250mg/kg (250mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937. |
Safety Profile
Hazard Codes of Histamine (CAS NO.51-45-6): 
Xn
Risk Statements: 22-36/37/38-42/43
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-26-36/37
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MS1050000
F: 3-10-23
HazardClass: 6.1(b)
PackingGroup: III
- About us
- |
- Payment
- |
- Contact us
- |
- Links
- |
- Help Center
- |
- Disclaimer
- |
- Add to favorite
- | SiteMap
- |
- Product SiteMap
- |
- Manufacturers
- |
- Suppliers
©2008 LookChem.com,License:ICP NO.：Zhejiang10014259
[Hangzhou]86-571-85317600,85317603,85317620