Basic information
- Name:
Heparin
- CAS No.:
9005-49-6
- Formula:
- Unspecified
- Deleted CAS:
- 9075-96-1,11078-24-3,11129-39-8,37324-73-5,91449-79-5,104521-37-1,1108625-99-5,1108626-06-7
- Synonyms:
- Ardeparin;AVE 5026;Centaxarin;CY 222;CY 216;Bemiparin;Arteven;Multiparin;Nadroparin;Nadroparine;Novoheparin;OP 386;OP 622;Octaparin;Pabyrn;Parnaparin;Reviparin;Subeparin;Tinzaparin;Vetren;a-Heparin;LipoHep Forte;KB 101;Heparin sulfate;Hapacarin;H 5284;Fraxiparin;Fragmin A;F 202;Clivarine;Clevarin;Mono-embolex;
- EINECS:
- 232-681-7
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Chemistry
Molecular Structure:
Molecular Formula: C26H41NO34S4
Molecular Weight: 1039.85
IUPAC Name: (4S,6R)-6-[(2R,4R)-4,6-Dihydroxy-5-(sulfonatoamino)-2-(sulfonatooxymethyl)oxan-3-yl]oxy-3,4-dihydroxy-5-sulfonatooxyoxane-2-carboxylate
Synonyms of Heparin (CAS NO.9005-49-6): Ardeparin ; Arteven ; Bemiparin ; CY 216 ; CY 222 ; Certoparin ; Dalteparin ; EINECS 232-681-7 ; Eparina ; Eparina [DCIT] ; FR 860 ; Fluxum ; Fragmin A ; Fragmin B ; Fraxiparin ; HSDB 3094 ; Hed-heparin ; Heparin CY 216 ; Heparin sulfate ; Heparina ; Heparina [INN-Spanish] ; Heparinate ; Heparine ; Heparine [INN-French] ; Heparinic acid ; Heparinum ; Heparinum [INN-Latin] ; Hepathrom ; KB 101 ; LMWH ; Multiparin ; Nadroparin ; OP 386 ; OP 622 ; Octaparin ; Pabyrin ; Parnaparin ; Parvoparin ; Pularin ; Reviparin ; Sandoparin ; Thromboliquine ; Tinzaparin ; UNII-E47C0NF7LV ; UNII-T2410KM04A ; Vetren ; Vitrum AB ; alpha-Heparin ; depo-Heparin
CAS NO: 9005-49-6
Classification Code: Anticoagulants ; Cardiovascular Agents ; Drug / Therapeutic Agent ; Fibrin Modulating Agents ; Fibrinolytic agents ; Hematologic Agents ; Human Data ; Mutation data ; Natural Product ; Reproductive Effect
Index of Refraction: 1.711
Molar Refractivity: 190.48 cm3
Molar Volume: 486.7 cm3
Surface Tension: 148.8 dyne/cm
Density: 2.13 g/cm3
History
Heparin (CAS NO.9005-49-6) is discovered in 1916 predates the establishment of the Food and Drug Administration of the United States, although it did not enter clinical trials until 1935.It was originally isolated from canine liver cells, hence its name. Heparin's discovery can be attributed to the research activities of two men, Jay McLean and William Henry Howell.
Uses
Heparin (CAS NO.9005-49-6) may sometimes be used to treat sports injuries.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | intravenous | 3536units/kg/ (3536units/kg) | Southern Medical Journal. Vol. 80, Pg. 1450, 1987. | |
| man | TDLo | subcutaneous | 1857units/kg/ (1857units/kg) | CARDIAC: OTHER CHANGES | Southern Medical Journal. Vol. 80, Pg. 1450, 1987. |
| mouse | LD50 | intraperitoneal | 1900mg/kg (1900mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 60, Pg. 507, 1964. |
| mouse | LD50 | intravenous | 500mg/kg (500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1366, 1986. |
| mouse | LD50 | subcutaneous | 500mg/kg (500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1366, 1986. |
| rat | LD50 | oral | 1950mg/kg (1950mg/kg) | German Offenlegungsschrift Patent Document. Vol. #2636091, | |
| rat | LDLo | intraperitoneal | 420mg/kg (420mg/kg) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959. | |
| women | TDLo | subcutaneous | 30uL/kg/5D-I (0.03mL/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | British Journal of Haematology. Vol. 82, Pg. 620, 1992. |
| women | TDLo | subcutaneous | 48mg/kg/20D-I (48mg/kg) | BLOOD: HEMORRHAGE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Australian and New Zealand Journal of Medicine. Vol. 28, Pg. 59, 1998. |
| women | TDLo | subcutaneous | 1000units/kg/ (1000units/kg) | Southern Medical Journal. Vol. 80, Pg. 1450, 1987. |
Safety Profile
Safety Statements of Heparin (CAS NO.9005-49-6): 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: MI0850000
F: 3-10
Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also HEPARIN SODIUM