Homoharringtonine (26833-87-4),Homoharringtonine (26833-87-4) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Homoharringtonine
CAS No.:
26833-87-4
Molecular Structure:
Formula:
C₂₉H₃₉NO₉
Molecular Weight:
545.69
Synonyms:
Cephalotaxine,4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]-;Homoharringtonine (8CI);CGX 635;Ceflatonin;Myelostat;NSC 141633;Omacetaxine mepesuccinate;Ephalotaxine, 4-methyl(2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester);
Density:
1.33 g/cm³
Melting Point:
144-146 °C
Boiling Point:
713.1 °C at 760 mmHg
Flash Point:
385.1 °C
Appearance:
Off-white cryst.
Hazard Symbols:
T+, Xi
Risk Codes:
26/27/28-36/37/38
Safety Description:
36/37/39-45-27-26 Details
Transport Information:
UN 1544 6.1/PG 2

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Chemistry

Product Name: Homoharringtonine
Molecular Weight: 545.62126 [g/mol]
Molecular Formula: C₂₉H₃₉NO₉
XLogP3: 0.8
H-Bond Donor: 2
H-Bond Acceptor: 10
storage temp.: 2-8 °C
Index of Refraction: 1.604
Molar Refractivity: 140.62 cm³
Molar Volume: 408.4 cm³
Surface Tension: 61.3 dyne/cm
Density: 1.33 g/cm³
Flash Point: 385.1 °C
Enthalpy of Vaporization: 109.46 kJ/mol
Boiling Point: 713.1 °C at 760 mmHg
Vapour Pressure: 2.41E-21 mmHg at 25 °C
Appearance: Off-white Cryst
Melting Point: 144-146 °C
Classification Code of Homoharringtonine (CAS NO.26833-87-4): Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Antineoplastic Agents; Antineoplastic agents, phytogenic; Drug / Therapeutic Agent; Growth Substances; Growth inhibitors; Natural Product; Treatment of acute myeloid leukemia; Treatment of chronic myeloid leukemia; Treatment of myelodysplasia
Product Categories: Alkaloids; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Cell Cycle RegulatorsCancer Research; DNA-RNA Transcription Regulators; Antitumor Agents; Apoptosis and Cell Cycle; Cell Cycle; Peptide Synthesis/Antibiotics

Uses

Homoharringtonine (CAS NO.26833-87-4) combined with some botanical drugs could induce cancer cells to resemble normal cells. It was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of a-ketoes.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD10	intravenous	640ug/kg (0.64mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) CARDIAC: CHANGE IN RATE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	National Cancer Institute Report. Vol. AUG1982,
mouse	LD50	intraperitoneal	3170ug/kg (3.17mg/kg)		Chinese Medical Journal Vol. 92, Pg. 175, 1979.
mouse	LD50	intravenous	2400ug/kg (2.4mg/kg)		Journal of Ethnopharmacology. Vol. 24, Pg. 1, 1988.
mouse	LD50	oral	7456ug/kg (7.456mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	subcutaneous	3948ug/kg (3.948mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO_x.
Safety information of Homoharringtonine (CAS NO.26833-87-4):
Hazard Codes: T+,Xi
Risk Statements: 26/27/28-36/37/38
R26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 36/37/39-45-27-26
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S27: Take off immediately all contaminated clothing
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
RTECS: FK0260000
HazardClass: 6.1(a)
PackingGroup: II

Specification

Homoharringtonine (CAS NO.26833-87-4), its Synonyms are 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate ; Ceflatonin ; Myelostat ; Omacetaxine mepesuccinate ; Omapro ; Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI) ; Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI) ; Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) ; Homoharringtonine (8CI) .