Basic information
- Name:
Hyaluronicacid, sodium salt
- Superlist Name:
- Sodium hyaluronate
- CAS No.:
9067-32-7
- Molecular Structure:
- Formula:
- (C14H20NO11Na)n
- Deleted CAS:
- 34448-35-6
- Synonyms:
- Arthrease;Artz Dispo;Artzal;Bio Hyaluro 12;Chlamyhyaluronic acid sodium salt;Cystistat;FCH 121-S;FCH 200;FCH 248;FCH 60;FCH 80;FCH-SU;Fermatron;HA-F;HA-Q;HA-Q 1;HA-QA;Hyaluronate sodium inj;Hyaluronate sodium;HE-QSE;Healon;Healon (polysaccharide);Healon GV;Healon V;Hyalart;Hyalein;Hyalgan;Hyaluronsan HA-LQ;Hyaluronsan HA-LQ1;Hyaluronsan HA-LQH;Hyaluronsan HA-Q;Hyaluronsan HA-QSS;Hyaluronsan M 5070;Hyasol;Hyasol BT;Hyladerm;Khionat;NRD 101;Nidelon;Opegan;Orthovisc;Ostenil;Provisc;SI 4402;SL 1010;SLM 10;SPH;Sinovial;Sodium hyaluronate;Suvenyl;
- Solubility:
- soluble in water
- Safety Description:
- 22-24/25 Details
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Chemistry
Molecular Formula: (C14H20NO11Na)n
EINECS: 232-678-0
Structure of Hyaluronicacid, sodium salt (CAS NO.9067-32-7):
Flash Point: 432.5 °C
Boiling Point: 791.6 °C
Storage temp: -20 °C
Merck: 13,4776
Solubility: H2O: 5 mg/mL, clear, colorless
Physical appearance: Solid. (Powdered solid.)
Stability: Stable. Incompatible with strong oxidizing agents
Product Categories: Substrates
Synonyms of Hyaluronicacid, sodium salt (CAS NO.9067-32-7): Arthrease ; Bio Hyaluro 12 ; Chlamyhyaluronic acid sodium salt ; Cystistat ; EUFLEXXA injection ; Equron (Veterinary) ; Healon ; Hyalart ; Hyaluronate Sodium ; Hyalurone sodium ;
Hyasol ; Khionat ; Legend ; Nidelon ; Orthovisc ; Ostenil ; Provisc ; Sinovial ; Sodium hyaluronate ; Supartz ; Suvenyl ;
Synacid (veterinary) .
Uses
Hyaluronic acid sodium salt (9067-32-7) is widely used in high-end cosmetics industry, for dry eye syndrome.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | subcutaneous | > 50mg/kg (50mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl, |
| mouse | LD50 | intraperitoneal | 1500mg/kg (1500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 1013, 1984. |
| mouse | LD50 | oral | > 2400mg/kg (2400mg/kg) | Drugs in Japan Vol. -, Pg. 849, 1990. | |
| mouse | LD50 | subcutaneous | > 4gm/kg (4000mg/kg) | BEHAVIORAL: ATAXIA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984. |
| rabbit | LD50 | intraperitoneal | 1820mg/kg (1820mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BLOOD: NORMOCYTIC ANEMIA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984. |
| rabbit | LD50 | oral | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. -, Pg. 849, 1990. | |
| rabbit | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984. |
| rat | LD50 | intraperitoneal | 1770mg/kg (1770mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BLOOD: NORMOCYTIC ANEMIA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984. |
| rat | LD50 | oral | > 800mg/kg (800mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984. | |
| rat | LD50 | subcutaneous | > 4gm/kg (4000mg/kg) | BEHAVIORAL: ATAXIA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984. |
Safety Profile
Hazard Codes: 
B,
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36/37/39-27-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: MT7250000
F: 3-10
Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of Na2O.
Specification
Precautions: Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F). Refrigerate. Store at tempertures from 2 - 8 °C.