Hydrocortisone (50-23-7),Hydrocortisone (50-23-7) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Hydrocortisone
CAS No.:
50-23-7
Molecular Structure:
Formula:
C₂₁H₃₀O₅
Molecular Weight:
362.46
Deleted CAS:
8056-08-4|80562-38-5|8063-42-1
Synonyms:
Cortisol(8CI);11b,17,21-Trihydroxypregn-4-ene-3,20-dione;11b,17,21-Trihydroxyprogesterone;11b,17a,21-Trihydroxypregn-4-ene-3,20-dione;11b-Hydroxycortisone;17-Hydroxycorticosterone;4-Pregnene-11b,17a,21-triol-3,20-dione;Acticort;Aeroseb HC;Ala-Cort;Anflam;Anti-inflammatory hormone;CaldeCort Spray;Cetacort;Cobadex;Cortanal;Cortef;Corticreme;Cortiment;Cortispray;Cortril;Dermocortal;Dihydrocostisone;Domolene-HC;DuoCort;Efcorbin;Eldecort;Esiderm H;Evacort;
EINECS:
200-020-1
Density:
1.28 g/cm³
Melting Point:
211-214 °C(lit.)
Boiling Point:
566.4 °C at 760 mmHg
Flash Point:
310.4 °C
Solubility:
water: 100 mg/mL
Appearance:
crystalline white powder
Hazard Symbols:
Xn
Risk Codes:
63-62-40
Safety Description:
36/37-45-36-22 Details

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Chemistry

IUPAC Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Canonical SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Isomeric SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey: JYGXADMDTFJGBT-VWUMJDOOSA-N
Molecular Formula: C₂₁H₃₀O₅
Molecular Weight: 362.46g/mol
EINECS: 200-020-1
Melting point: 211-214 °C(lit.)
Storage temp.: -20°C
Solubility: H₂O: 100 mg/mL
Index of Refraction: 1.594
Molar Refractivity: 95.57 cm³
Molar Volume: 281.3 cm³
Surface Tension: 58.8 dyne/cm
Density: 1.28 g/cm³
Flash Point: 310.4 °C
Enthalpy of Vaporization: 97.71 kJ/mol
Boiling Point: 566.4 °C at 760 mmHg
Vapour Pressure: 3.44E-15 mmHg at 25 °C
XLogP3-AA: 1.6
H-Bond Donor: 3
H-Bond Acceptor: 5
Product Categories of Hydrocortisone (CAS NO.50-23-7): TPI; Steroids; Veterinaries

Uses

Hydrocortisone (CAS NO.50-23-7) is used to treat a variety of different illnesses.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	400mg/kg/10D- (400mg/kg)	BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS	Psychopharmacology Vol. 145, Pg. 260, 1999.
mouse	LD50	subcutaneous	> 500mg/kg (500mg/kg)		Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990.
rat	LD50	intraperitoneal	150mg/kg (150mg/kg)		Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971.
rat	LD50	subcutaneous	449mg/kg (449mg/kg)		Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by subcutaneous route. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits very toxic fumes of SO_x and NO_x.
Hazard Codes: Xn Harmful
WGK Germany: 3
Risk Statements: 63-62-40
R62: Risk of impaired fertility.
R63: Possible risk of harm to the unborn child.
R40: Limited evidence of a carcinogenic effect.
Safety Statements of Hydrocortisone (CAS NO.50-23-7): 36/37-45-36-22
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36: Wear suitable protective clothing.
S22: Do not breathe dust.

Specification

Hydrocortisone , its CAS NO. is 50-23-7, the synonyms are Cortisol ; 11-beta,17-alpha,21-trihydroxypregn-4-ene-3,20-dione ; Hydrocortisone Base ; Cor-Tar-Quin ; Cort-Quin ; Cortisporin ; Drotic ; Neo-Cort-Dome ; Cortisol .