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Hydroxyzine

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Hydroxyzine

EINECS 200-693-1
CAS No. 68-88-2 Density 1.1020 (rough estimate)
PSA 35.94000 LogP 2.93170
Solubility < 700 mg/mL Melting Point 190 ºC
Formula C21H27 Cl N2 O2 Boiling Point 250 °C(Press: 0.1 Torr)
Molecular Weight 374.911 Flash Point N/A
Transport Information N/A Appearance Yellow Oil
Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of Cl and NOx. Risk Codes R11; R20/22; R35
Molecular Structure Molecular Structure of 68-88-2 (1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine)) Hazard Symbols N/A
Synonyms

Ethanol,2-[2-[4-(4-chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]- (6CI); Ethanol, 2-[2-[4-(p-chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]-(8CI); (?à)-Hydroxyzine; 1-(p-Chloro-a-phenylbenzyl)-4-[2-((2-hydroxyethoxy)ethyl)]piperazine;1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine;1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine;1-(p-Chlorodiphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine;2-[2-[4-(p-Chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol; Hydroxizine; Hydroxyzin;Hydroxyzine; Hydroxyzyne; NSC 169188; Tran-Q; Tranquizine; U.C.B 4492

Article Data 4

Hydroxyzine Chemical Properties

Chemical Name: 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine)
IUPAC NAME: 2-[2-[4-[(4-Chlorophenyl)-phenylmethyl]piperazin-1-
yl]ethoxy]ethanol
CAS No.: 68-88-2
EINECS: 200-693-1
RTECS: KK2275000
RTECS Class: Drug ;  Reproductive Effector
Molecular Formula: C21H27ClN2O2
Molecular Weight: 374.90 g/mol
Melting Point: 190°C
Density: 1.182 g/cm3 
Flash Point: 255.7 °C
Boiling Point: 499.2 °C at 760 mmHg 
Following is the structure of 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine) (68-88-2):


Product Categories about 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine) (68-88-2) are Intermediates & Fine Chemicals ; Pharmaceuticals
The chemical synonymous of 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine) (68-88-2) are 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-((2-hydroxyethoxy)ethyl)piperazine ; 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine ; 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine ; 1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine ; 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol ; 2-(2-(4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl)ethoxy)ethanol ; Atara ; Atarax

Hydroxyzine Toxicity Data With Reference

1.    

orl-rat LD50:840 mg/kg

    CHTPBA    Chimica Therapeutica. 3 (1968),210.
2.    

ipr-rat LD50:160 mg/kg

    CHTPBA    Chimica Therapeutica. 3 (1968),210.
3.    

ivn-rat LD50:45 mg/kg

    ANPBAZ    Acta Neurologia et Psychiatrica Belgica. 61 (1961),669.
4.    

orl-mus LD50:480 mg/kg AANEAB 7,87,63

5.    

ipr-mus LD50:81,300 µg/kg

    DPHFAK    Dissertationes Pharmaceuticae et Pharmacologicae. 23 (1971),281.
6.    

ivn-mus LD50:137 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,237.

Hydroxyzine Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of Cl and NOx.
Attentions:
1. Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
2. Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
 

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