Ibudilast (50847-11-5),Ibudilast (50847-11-5) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Ibudilast
CAS No.:
50847-11-5
Molecular Structure:
Formula:
C₁₄H₁₈N₂O
Molecular Weight:
230.31
Synonyms:
Pyrazolo[1,5-a]pyridine,1-propanone deriv.;1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one;2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine;AV 411;KC 404;Ketas;1-Propanone,2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-;
Density:
1.09 g/cm³
Melting Point:
53-54 °C
Solubility:
DMSO: 28 mg/mL, soluble
Appearance:
white solid
Hazard Symbols:
Xn
Risk Codes:
22-36/37/38
Safety Description:
26-36 Details

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Chemistry

IUPAC Name: 2-Methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one

Molecular Structure:
Molecular Formula: C₁₄H₁₈N₂O
Molecular Weight: 230.31
CAS NO: 50847-11-5
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 3
Polar Surface Area: 34.37 Å²
Index of Refraction: 1.57
Molar Refractivity: 69.08 cm³
Molar Volume: 210.2 cm³
Surface Tension: 35.9 dyne/cm
Density: 1.09 g/cm³
Melting Point: 53-54°C
Storage temp: 2-8°C
Solubility : DMSO: 28 mg/mL, soluble
Appearance: white solid
Synonyms of Ibudilast (CAS NO.50847-11-5): 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine ; 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone ; 2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Cyclic Nucleotide related

Uses

Ibudilast (CAS NO.50847-11-5) is used as an antiallergic, antiasthmatic, and vasodilator. And Ibudilast is mainly used in the treatment of asthma and stroke. It may also be useful in the treatment of multiple sclerosis.

Production

In the presence of Potassium carbonate and Sodium acetate, 1-Amino-2-methyl-pyridine halide anchor reacts with Isobutyric anhydride to form Ibudilast.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	460mg/kg (460mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	intravenous	146mg/kg (146mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	oral	1860mg/kg (1860mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	subcutaneous	3100mg/kg (3100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	intraperitoneal	419mg/kg (419mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	intravenous	42500ug/kg (42.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE KIDNEY, URETER, AND BLADDER: HEMATURIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	oral	1340mg/kg (1340mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	subcutaneous	1300mg/kg (1300mg/kg)	KIDNEY, URETER, AND BLADDER: HEMATURIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.

Safety Profile

Safety Information about Ibudilast (CAS NO.50847-11-5):
Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: UR0711200