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Cas Database |
| Name |
Isoniazid |
EINECS | N/A |
| CAS No. | 7640-37-1 | Density | N/A |
| PSA | N/A | LogP | N/A |
| Solubility | N/A | Melting Point |
N/A |
| Formula | N/A | Boiling Point | N/A |
| Molecular Weight | 137.141 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
N/A |
Article Data | 144 |
Isoniazid Chemical Properties
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IUPAC Name: Pyridine-4-carbohydrazide
Molecular Formula: C6H7N3O
Molecular Weight: 137.13928 g/mol
Canonical SMILES: C1=CN=CC=C1C(=O)NN
InChI: InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
Classification Code: Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial [tuberculostatic]; Antilipemic Agents; Antimetabolites; Antitubercular agents; Drug / Therapeutic Agent; Fatty Acid Synthesis Inhibitors; Human Data; Mutation data; Reproductive Effect; Skin / Eye Irritant; Tumor data
Melting Point: 171.4 °C
Index of Refraction: 1.583
Molar Refractivity: 36.86 cm3
Molar Volume: 110.1 cm3
Surface Tension: 57.8 dyne/cm
Density of Isoniazid (CAS NO.7640-37-1): 1.244 g/cm3
Isoniazid Uses
Isoniazid (CAS NO.7640-37-1) is the first-line antituberculosis medication in prevention and treatment. It is the most potent and selective of the tuberculostatic antibacterial agents.
Isoniazid Production
Isoniazid may be prepared by the base hydrolysis of 4-cyanopyridine to give the amide, followed by displacement of ammonia by hydrazine:
Isoniazid Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intraperitoneal | 325mg/kg (325mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Klinische Wochenscrift. Vol. 30, Pg. 959, 1952. |
| child | TDLo | oral | 125mg/kg (125mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA | Annals of Emergency Medicine. Vol. 17, Pg. 73, 1988. |
| child | TDLo | oral | 195mg/kg (195mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: HEADACHE | Japanese Journal of Toxicology. Vol. 12, Pg. 225, 1999. |
| child | TDLo | oral | 3600mg/kg/43W (3600mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Canadian Medical Association Journal. Vol. 148, Pg. 49, 1993. |
| dog | LD50 | oral | 50mg/kg (50mg/kg) | American Review of Tuberculosis. Vol. 65, Pg. 392, 1952. | |
| guinea pig | LD50 | intramuscular | 255mg/kg (255mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| guinea pig | LD50 | intraperitoneal | 195mg/kg (195mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Klinische Wochenscrift. Vol. 30, Pg. 959, 1952. |
| guinea pig | LD50 | intravenous | 220mg/kg (220mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Archiv fuer Toxikologie. Vol. 22, Pg. 80, 1966. |
| guinea pig | LD50 | oral | 255mg/kg (255mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| guinea pig | LD50 | subcutaneous | 195mg/kg (195mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| human | LDLo | oral | 100mg/kg (100mg/kg) | PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH | American Review of Respiratory Disease. Vol. 105, Pg. 206, 1972. |
| infant | TDLo | oral | 91mg/kg (91mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Pediatrics. Vol. 95, Pg. 700, 1995. |
| man | LDLo | oral | 116mg/kg (116mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA | Journal of Analytical Toxicology. Vol. 16, Pg. 57, 1992. |
| man | LDLo | oral | 523mg/kg/17W- (523mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" | JAMA, Journal of the American Medical Association. Vol. 176, Pg. 877, 1961. |
| man | TDLo | oral | 39mg/kg/9D-I (39mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Southern Medical Journal. Vol. 75, Pg. 81, 1982. |
| man | TDLo | oral | 100mg/kg/3W-C (100mg/kg) | BEHAVIORAL: ANOREXIA (HUMAN SKIN AND APPENDAGES (SKIN): SWEATING: OTHER KIDNEY, URETER, AND BLADDER: OTHER CHANGES | American Review of Respiratory Disease. Vol. 106, Pg. 849, 1972. |
| man | TDLo | oral | 430mg/kg (430mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Neurology. Vol. 20, Pg. 299, 1970. |
| mouse | LD50 | intramuscular | 137mg/kg (137mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | American Review of Tuberculosis. Vol. 65, Pg. 376, 1952. |
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | intravenous | 149mg/kg (149mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958. |
| mouse | LD50 | oral | 133mg/kg (133mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | American Review of Tuberculosis. Vol. 65, Pg. 376, 1952. |
| mouse | LD50 | subcutaneous | 125mg/kg (125mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 1225, 1961. |
| rabbit | LD50 | intracrebral | > 12mg/kg (12mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rabbit | LD50 | intramuscular | 155mg/kg (155mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rabbit | LD50 | intraperitoneal | 147mg/kg (147mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rabbit | LD50 | intravenous | 94mg/kg (94mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | American Review of Tuberculosis. Vol. 65, Pg. 376, 1952. |
| rabbit | LD50 | oral | 250mg/kg (250mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 22, 1962. | |
| rabbit | LD50 | subcutaneous | 135mg/kg (135mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rat | LD50 | intramuscular | 400mg/kg (400mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Therapie. Vol. 8, Pg. 62, 1953. |
| rat | LD50 | intraperitoneal | 335mg/kg (335mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rat | LD50 | intravenous | 365mg/kg (365mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 409, 1976. | |
| rat | LD50 | oral | 1250mg/kg (1250mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 409, 1976. | |
| rat | LD50 | subcutaneous | 329mg/kg (329mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957. | |
| women | TDLo | oral | 12mg/kg/2D-I (12mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: ATAXIA | Neurology. Vol. 34, Pg. 703, 1984. |
| women | TDLo | oral | 90200ug/kg/7D (90.2mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | Pediatrics. Vol. 97, Pg. 782, 1996. |
| women | TDLo | oral | 99300ug/kg (99.3mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING | Pediatrics. Vol. 95, Pg. 700, 1995. |
| women | TDLo | oral | 11250mg/kg (11250mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Anaesthesia. Vol. 47, Pg. 781, 1992. |
Isoniazid Specification
Isoniazid (CAS NO.7640-37-1), its Synonyms are 4-(Hydrazinocarbonyl)pyridine ; 4-Pyridinecarbonylhydrazine ; 4-Pyridinecarboxylic acid, hydrazide ; 4-Pyridinecarboxylic hydrazide ; 4-Pyridylcarbonylhydrazide ; Antimicina ; Antituberkulosum ; Armazid ; Armazide ; Isonicotinic acid hydrazide ; Isonicotinic hydrazide ; Isonicotinohydrazide .
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