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Isopropyl methanefluorophosphonate

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Name

Isopropyl methanefluorophosphonate

EINECS N/A
CAS No. 107-44-8 Density 1.07g/cm3
PSA 36.11000 LogP 2.20380
Solubility N/A Melting Point -56 C
Formula C4H10FO2P Boiling Point 147°Cat760mmHg
Molecular Weight 140.094 Flash Point 42.7°C
Transport Information N/A Appearance liquid
Safety A deadly human poison by skin contact and inhalation. (A small drop on the skin can kill a man.) A deadly experimental poison by ingestion, inhalation, skin contact, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects: muscle weakness, bronchiolar constriction, nausea or vomiting, flaccid paralysis without anesthesia, miosis (pupillary constriction), cholinesterase inhibition. A “nerve gas” used as a chemical warfare agent. To fight fire, use foam, CO2, dry chemical. When heated to decomposition or reacted with steam, it emits very toxic fumes of F and POx. See also PARATHION. Risk Codes N/A
Molecular Structure Molecular Structure of 107-44-8 (Sarin.) Hazard Symbols Toxic by inhalation and skin absorption, cholinesterase inhibitor.
Synonyms

Sarin.;SARINTYPEII;O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE;AGENTGB;SARIN-I;ISOPROPYLMETHYLPHOSPHONOFLUORIDATE;SARINTYPEI;SARIN-II

Article Data 3

Isopropyl methanefluorophosphonate Chemical Properties

IUPAC Name: 2-[Fluoro(methyl)phosphoryl]oxypropane
Synonyms of Isopropyl methanefluorophosphonate (CAS NO.107-44-8) : Phosphonofluoridic acid, P-methyl-, 1-methylethyl ester ; Propan-2-yl methylphosphonofluoridate ; (+-)-Isopropyl methylphosphonofluoridate ; 1-Methylethyl (+-)-methylphosphonofluoridate
CAS NO:107-44-8
Molecular Formula:C4H10FO2P
Molecular Weight :140.0932
Molecular Structure :
Index of Refraction:1.366
Surface Tension: 24 dyne/cm
Density: 1.07 g/cm3
Flash Point: 42.7 °C
Enthalpy of Vaporization: 36.82 kJ/mol
Boiling Point: 147 °C at 760 mmHg
Vapour Pressure: 5.71 mmHg at 25°C
Stability: Stability
Appearance: Isopropyl methanefluorophosphonate (CAS NO.107-44-8) is a colorless, odorless liquid.

Isopropyl methanefluorophosphonate Uses

 Isopropyl methanefluorophosphonate (CAS NO.107-44-8) is used as a quick-acting military chemical nerve agent and chemical warfare agent.

Isopropyl methanefluorophosphonate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 22ug/kg (0.022mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961.
cat LD50 subcutaneous 30ug/kg (0.03mg/kg)   Toxicology and Applied Pharmacology. Vol. 91, Pg. 55, 1987.
chicken LD50 subcutaneous 16673ug/kg (16.673mg/kg)   Archives of Toxicology. Vol. 52, Pg. 71, 1983.
dog LD50 intravenous 19ug/kg (0.019mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961.
guinea pig LC50 inhalation 128mg/m3/2M (128mg/m3)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1126, 1986.
guinea pig LD50 subcutaneous 30ug/kg (0.03mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
hamster LD50 subcutaneous 95ug/kg (0.095mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
human LD50 skin 28mg/kg (28mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Science Journal. Vol. 3(4), Pg. 33, 1967.
human TDLo oral 2ug/kg (0.002mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
man LDLo intramuscular 30ug/kg (0.03mg/kg)   Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
man TCLo inhalation 90ug/m3 (0.09mg/m3) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE Archives of Toxicology. Vol. 56, Pg. 201, 1985.
Link to PubMed
man TDLo oral 102ug/kg/3D-I (0.102mg/kg) BLOOD: OTHER CHANGES Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
monkey LD50 intramuscular 22300ng/kg (0.0223mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Fundamental and Applied Toxicology. Vol. 5, Pg. S169, 1985.
monkey LD50 intravenous 20ug/kg (0.02mg/kg)   Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
mouse LC50 inhalation 5mg/m3/30M (5mg/m3)   Deutsche Gesundheitswesen. Vol. 15, Pg. 2179, 1960.
mouse LD50 intramuscular 164ug/kg (0.164mg/kg)   Journal of Medicinal Chemistry. Vol. 31, Pg. 807, 1988.
mouse LD50 intraperitoneal 283ug/kg (0.283mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 172, Pg. 62, 1968.
mouse LD50 intravenous 109ug/kg (0.109mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: INCONTINENCE
Journal of Toxicology and Environmental Health. Vol. 26, Pg. 437, 1989.
mouse LD50 skin 1080ug/kg (1.08mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
National Technical Information Service. Vol. PB158-508,
mouse LD50 subcutaneous 60ug/kg (0.06mg/kg)   Deutsche Gesundheitswesen. Vol. 15, Pg. 2179, 1960.
pig LD50 intravenous 15ug/kg (0.015mg/kg)   Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
pig LD50 skin 116mg/kg (116mg/kg)   Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
rabbit LD50 intravenous 15ug/kg (0.015mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 353, 1961.
rabbit LD50 skin 925ug/kg (0.925mg/kg)

BEHAVIORAL: COMA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS


LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

National Technical Information Service. Vol. PB158-508,
rabbit LD50 subcutaneous 30ug/kg (0.03mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: MUSCLE WEAKNESS
Toxicology and Applied Pharmacology. Vol. 40, Pg. 109, 1977.
rat LD50 intramuscular 108ug/kg (0.108mg/kg)   Fundamental and Applied Toxicology. Vol. 5, Pg. S84, 1985.
rat LD50 intraperitoneal 218ug/kg (0.218mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 139, Pg. 390, 1963.
rat LD50 intravenous 39ug/kg (0.039mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 139, Pg. 390, 1963.
rat LD50 oral 550ug/kg (0.55mg/kg) BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
National Technical Information Service. Vol. PB158-508,
rat LD50 skin 2500ug/kg (2.5mg/kg)   Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
rat LD50 subcutaneous 103ug/kg (0.103mg/kg)   British Journal of Pharmacology. Vol. 39, Pg. 822, 1970.

Isopropyl methanefluorophosphonate Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Isopropyl methanefluorophosphonate Safety Profile

A deadly human poison by skin contact and inhalation. (A small drop on the skin can kill a man.) A deadly experimental poison by ingestion, inhalation, skin contact, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects: muscle weakness, bronchiolar constriction, nausea or vomiting, flaccid paralysis without anesthesia, miosis (pupillary constriction), cholinesterase inhibition. A “nerve gas” used as a chemical warfare agent. To fight fire, use foam, CO2, dry chemical. When heated to decomposition or reacted with steam, it emits very toxic fumes of F and POx. See also PARATHION.

RIDADR 2810
HazardClass 6.1(a)
PackingGroup I

Isopropyl methanefluorophosphonate Specification

1.Air & Water Reactions: Hydrolyzed by water, rapidly hydrolyzed by dilute aqueous sodium hydroxide. Water alone removes Fluoride atom producing nontoxic acid .
2.Reactivity Profile: Acidic conditions produce hydrogen fluoride; alkaline conditions produce isopropyl alcohol and polymers. When heated to decomposition or reacted with steam, Sarin. emits very toxic fumes of fluorides and oxides of phosphorus. Slightly corrosive to steel. Hydrolyzed by water 
3.Health Hazard :Extremely toxic; lethal dose in humans may be as low as 0.01 mg/kg. Extremely active cholinesterase inhibitor. Toxic effects similar to, but more severe than those of parathion. Death within 15 minutes after fatal dose is absorbed.
4.Fire Hazard: Non-flammable. Acidic conditions produce hydrogen fluoride; alkaline conditions produce isopropyl alcohol and polymers. When heated to decomposition or reacted with steam, Sarin. emits very toxic fumes of fluorides and oxides of phosphorus. Slightly corrosive to steel. Hydrolyzed by water.

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