- Isoxsuprine
- Isoxsuprine hydrochloride
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| Name |
Isoxsuprine hydrochloride |
EINECS | 209-443-6 |
| CAS No. | 579-56-6 | Density | 1.146g/cm3 |
| PSA | 61.72000 | LogP | 4.06410 |
| Solubility | N/A | Melting Point |
203-204° |
| Formula | C18H23NO3.HCl | Boiling Point | 484.2 °C at 760 mmHg |
| Molecular Weight | 337.846 | Flash Point | 246.6 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 36 | Risk Codes | 22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-,hydrochloride (9CI);Benzyl alcohol, p-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-,hydrochloride (8CI);Norephedrine, p-hydroxy-N-(1-methyl-2-phenoxyethyl)-,hydrochloride (6CI);1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxy)ethylaminopropanol-1hydrochloride;Dilavase;Divadilan;Duvadilan;Duviculine;Isolait;Isoxsuprinhydrochloride;Isoxsuprine hydrochloride;Navilox;Suprilent;Suprox SR;Vadosilan;Vasodilan;Vasoplex;Vasotran; |
Isoxsuprine hydrochloride Chemical Properties
Chemistry informtion about Vasodilan (CAS NO.579-56-6) is:
IUPAC Name: 4-[1-Hydroxy-2-(1-Phenoxypropan-2-Ylamino)Propyl]Phenol Hydrochloride
Synonyms: Isoxsuprine Hcl ; Isoxsuprine Hydrochloride ; 1-(P-Hydroxyphenyl)-2-(1'-Methyl-2'-Phenoxy)Ethylaminopropanol-1hydrochlorid ; 2-(3-Phenoxy-2-Propylamino)-1-(P-Hydroxyphenyl)-1-Propanolhydrochloride ; Isolait ; Isoxsuprinhydrochloride ; P-Hydroxy-Alpha-(1-((1-Methyl-2-Phenoxyethyl)Amino)Ethyl)-Benzylalcohohyd ; Suprilent
MF: C18H24ClNO3
MW: 337.84
EINECS: 209-443-6
Flash Point: 246.6 °C
Boiling Point: 484.2 °C at 760 mmHg
Vapour Pressure: 3.45E-10 mmHg at 25°C
Enthalpy of Vaporization: 78.94 kJ/mol
Following is the molecular structure of Vasodilan (CAS NO.579-56-6) is:
Isoxsuprine hydrochloride Uses
Vasodilan (CAS NO.579-56-6) relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. These actions may help treat the symptoms of conditions such as cerebral vascular insufficiency (poor blood flow to the brain), arteriosclerosis (hardening of the arteries), Raynaud's phenomenon, and other conditions involving poor blood flow in the veins and arteries. It may also be used for purposes other than those listed in this medication guide.
Isoxsuprine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 57mg/kg (57mg/kg) | behavioral: ataxia cardiac: change in rate skin and appendages (skin): "dermatitis, other: after systemic exposure" | Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959. |
| dog | LD50 | oral | > 1200mg/kg (1200mg/kg) | gastrointestinal: nausea or vomiting | Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959. |
| dog | LD50 | subcutaneous | 143mg/kg (143mg/kg) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959. | |
| mouse | LD50 | intraperitoneal | 185mg/kg (185mg/kg) | behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands | Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959. |
| mouse | LD50 | intravenous | 61mg/kg (61mg/kg) | behavioral: excitement gastrointestinal: changes in structure or function of salivary glands lungs, thorax, or respiration: respiratory depression | Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959. |
| mouse | LD50 | oral | 1100mg/kg (1100mg/kg) | behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands | Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959. |
| mouse | LD50 | subcutaneous | 1500mg/kg (1500mg/kg) | behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands | Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959. |
| rat | LD50 | intraperitoneal | 164mg/kg (164mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| rat | LD50 | intravenous | 77mg/kg (77mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
| rat | LD50 | oral | 1750mg/kg (1750mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
Isoxsuprine hydrochloride Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Used as a vasodilator. When heated to decomposition it emits toxic fumes of NOx and HCl.
Hazard Codes:
Xn
Risk Statements:
R22:Harmful if swallowed.
Safety Statements:
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DO8225000
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