Basic information
- Name:
Ivermectin
- CAS No.:
70288-86-7
- Formula:
- Unspecified
- Synonyms:
- Ivermectin EP6;
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Chemistry
Ivermectin (22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b) is a broad-spectrum antiparasitic medication. Ivermectin is a mixture of two compounds 22,23-dihydroavermectin B1a and 22,23-dihydroavermectin B1b, which differ by a single ethyl or methyl side group.
Uses
It is traditionally used against worms, but more recently found to be effective against mites and some lice too.
Mectizan is currently being used to help eliminate river blindness (onchocerciasis) in the Americas and stop transmission of lymphatic filariasis around the world. Currently, large amounts of Mectizan are donated by Merck to fight river blindness in countries that are unable to afford the drug.
Toxicity Data With Reference
scu-ctl LDLo:8 mg/kg SCIEAS Science. 221 (1983),823.
The main concern is neurotoxicity, which in most mammalian species may manifest as CNS depression, and consequent ataxia, as might be expected from potentiation of inhibitory GABA-ergic synapses.
Safety Profile
Poison by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.
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