Basic information
- Name:
Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione,5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-,(2'S,3'S,5R,6R,14aR,14bR)-
- CAS No.:
6870-67-3
- Molecular Structure:
![Molecular Structure of 6870-67-3 (Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione,5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-,(2'S,3'S,5R,6R,14aR,14bR)-)](http://www.lookchem.com/300w/2010/0623/6870-67-3.jpg)
- Formula:
- C18H25 N O6
- Molecular Weight:
- 351.44
- Synonyms:
- Jacobine(6CI,7CI,8CI); Senecionan-11,16-dione, 15,20-epoxy-15,20-dihydro-12-hydroxy-,(15a,20S)-; NSC 89936;Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione,5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-,[3S-[3R*(R*),5S*,6S*,14aS*,14bS*]]-
- Safety Description:
- Poison by intravenous route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Details
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Chemistry
Jacobine(6870-67-3)'s molecular formula is C18H25NO6 and its formula weight is 351.44.
Jacobine(6870-67-3)'s chemical synonyms are Jacobine(6870-67-3);(15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione;(20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione;NSC-89936.
The molecular structure of jacobine(6870-67-3):
Jacobine(6870-67-3)'s chemical synonyms are Jacobine(6870-67-3);(15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione;(20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione;NSC-89936.
The molecular structure of jacobine(6870-67-3):
Toxicity Data With Reference
| 1. | sln-dmg-par 20 µmol/L | ZEVBA5 Zeitschrift fuer Verebungslehre. 91 (1960),74. | ||
| 2. | dns-rat:lvr 1 µmol/L | CNREA8 Cancer Research. 45 (1985),3125. | ||
| 3. | ivn-mus LD50:77 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 75 (1942),69. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 (1976),p. 275.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Safety Profile
Poison by intravenous route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.