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JACOBINE

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JACOBINE

EINECS
CAS No. 6870-67-3 Density
Solubility Melting Point
Formula C18H25 N O6 Boiling Point
Molecular Weight 351.44 Flash Point
Transport Information Appearance
Safety Poison by intravenous route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Risk Codes
Molecular Structure Molecular Structure of 6870-67-3 (Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione,5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-,(2'S,3'S,5R,6R,14aR,14bR)-) Hazard Symbols
Synonyms

Jacobine(6CI,7CI,8CI); Senecionan-11,16-dione, 15,20-epoxy-15,20-dihydro-12-hydroxy-,(15a,20S)-; NSC 89936;Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione,5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-,[3S-[3R*(R*),5S*,6S*,14aS*,14bS*]]-

 

JACOBINE Chemical Properties

Jacobine(6870-67-3)'s molecular formula is C18H25NO6  and its formula weight is 351.44.
Jacobine(6870-67-3)'s chemical synonyms are Jacobine(6870-67-3);(15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione;(20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione;NSC-89936. 
The molecular structure of jacobine(6870-67-3):

JACOBINE Toxicity Data With Reference

1.   

sln-dmg-par 20 µmol/L

   ZEVBA5    Zeitschrift fuer Verebungslehre. 91 (1960),74.
2.   

dns-rat:lvr 1 µmol/L

   CNREA8    Cancer Research. 45 (1985),3125.
3.   

ivn-mus LD50:77 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 75 (1942),69.

JACOBINE Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 (1976),p. 275.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

JACOBINE Safety Profile

Poison by intravenous route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

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