KF-868 (54240-36-7),KF-868 (54240-36-7) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Benzenemethanol,4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-,hydrochloride (1:1)
Superlist Name:
Mabuterol hydrochloride
CAS No.:
54240-36-7
Molecular Structure:
Formula:
C13H18 Cl F3 N2 O . Cl H
Molecular Weight:
347.24
Deleted CAS:
95656-48-7
Synonyms:
Benzenemethanol,4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-,monohydrochloride (9CI);Broncholin;KF 868;KF 868 (pharmaceutical);dl-Mabuterol hydrochloride;Mabuterol Hydrochloride;
Density:
g/cm³
Boiling Point:
375.9°Cat760mmHg
Flash Point:
181.1°C
Safety Description:
Poison by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F⁻, NO_x, and HCl. Details

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Chemistry

Product Name: KF-868 (CAS NO.54240-36-7)

Molecular Formula: C₁₃H₁₈ClF₃N₂O.HCl
Molecular Weight: 347.2g/mol
Mol File: 54240-36-7.mol
Appearance: A solid
Boiling point: 375.9°Cat760mmHg
Flash Point: 181.1 °C
Enthalpy of Vaporization: 65.77 kJ/mol
Vapour Pressure: 2.57E-06 mmHg at 25°C
H-Bond Donor: 4
H-Bond Acceptor: 6

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	27500ug/kg (27.5mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
dog	LD50	oral	229mg/kg (229mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
human	TDLo	oral	1143ng/kg (0.001143mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: HEADACHE	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1697, 1984.
human	TDLo	oral	60ug/kg/6W (0.06mg/kg)	BEHAVIORAL: TREMOR CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1699, 1984.
mouse	LD50	intraperitoneal	60mg/kg (60mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
mouse	LD50	intravenous	36500ug/kg (36.5mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 652, 1984.
mouse	LD50	oral	200mg/kg (200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
mouse	LD50	subcutaneous	113mg/kg (113mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rabbit	LD50	intravenous	18300ug/kg (18.3mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rabbit	LD50	oral	243mg/kg (243mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rat	LD50	intraperitoneal	76300ug/kg (76.3mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rat	LD50	intravenous	26400ug/kg (26.4mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rat	LD50	oral	306mg/kg (306mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rat	LD50	subcutaneous	117mg/kg (117mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.

Safety Profile

Poison by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F⁻, NO_x, and HCl.

Specification

KF-868 ,its CAS NO. is 54240-36-7,the synonyms is Mabuterolhcl ; Benzenemethanol, 4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-, monohydrochloride (9ci) ; Broncholin ; Dl-mabuterol hydrochloride ; KF868 (pharmaceutical) .