Kepone (143-50-0),Kepone (143-50-0) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
1,3,4-Metheno-2H-cyclobuta[cd]pentalen-2-one,1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-
CAS No.:
143-50-0
Molecular Structure:
Formula:
C10Cl10 O
Molecular Weight:
490.60
Synonyms:
1,3,4-Metheno-2H-cyclobuta[cd]pentalen-2-one,decachlorooctahydro- (6CI);1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one;Chlordecone; Clordecone; Compound 1189; Decachloroketone;Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one;Decachloropentacyclo[5.2.1.02,6.03,9.05,8]decan-4-one; ENT-16391; GC 1189;Kepone; NSC 124074; NSC 56532
EINECS:
205-601-3
Annex I Index No: 606-019-00-6

Solubility:

Stability Stable. Incompatible with strong oxidizing agents. Toxicology Toxic if swallowed or absorbed through the skin. May act as a carcinogen. Toxicity data (

Appearance:

white powder

Hazard Symbols:

A carcinogen. Toxic by ingestion, inhalation, and skin absorption. Manufacture and use have been prohibited.

Safety Description:

Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion, skin contact. Experimental teratogenic and reproductive effects. Mutation data reported. Inhalation, absorption, or ingestion by humans can lead to central nervous system, liver, and kidney damage, including bizarre symptoms caused by damage to the nervous system. Usually, the symptoms are tremors, ataxia, skin changes, hyperexcitability, hyperactivity, muscle spasms, testicular atrophy, low sperm count, estrogenic effects, sterility, breast enlargement, liver lesions, and cancer. An insecticide and fungicide. Registration suspended by the USEPA.

Analytical Methods:

For occupational chemical analysis use NIOSH: Kepone, 5508. Details

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Chemistry

CAS: 143-50-0
EINECS: 205-601-3
Following is the Molecular Structure of Kepone (143-50-0):

SMILES: ClC54C(=O)C1(Cl)C2(Cl)C5(Cl)C3(Cl)C4(Cl)C1(Cl)C2(Cl)C3(Cl)Cl
InChI: InChI=1/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20
InChIKey: LHHGDZSESBACKH-UHFFFAOYAM
Std.InChI: InChI=1S/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20
Std.InChIKey: LHHGDZSESBACKH-UHFFFAOYSA-N
Molecular Formula: C₁₀Cl₁₀O
Molecular Weight: 490.64
Boiling Point: 450.5℃ at 760mmHg
Flash Point: 189.8℃
Molar Volume: 215.6cm³
Density: 2.27g/cm³
Molar Refractivity: 86.66cm³
Surface Tension: 79.6dyne/cm
Polarizability: 34.35 10^-24cm³
Enthalpy of Vaporization: 70.93kJ/mol
Vapour Pressure: 2.63E-08mmHg at 25℃

Uses

Used in the production of pesticide.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	250mg/kg (250mg/kg)	BEHAVIORAL: TREMOR	Toxicology and Applied Pharmacology. Vol. 45, Pg. 331, 1978.
mammal (species unspecified)	LD50	unreported	126mg/kg (126mg/kg)		"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 65, 1971.
quail	LD50	oral	237mg/kg (237mg/kg)		Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976.
rabbit	LD50	oral	65mg/kg (65mg/kg)		Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 642, 1966.
rabbit	LD50	skin	345mg/kg (345mg/kg)		Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 96, 1973.
rat	LD50	oral	91300ug/kg (91.3mg/kg)		Neurobehavioral Toxicology and Teratology. Vol. 5, Pg. 91, 1983.
rat	LD50	skin	> 2gm/kg (2000mg/kg)		Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.

Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7(1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 (1979),p. 67.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 (1979),p. 67.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Safety Profile

Hazard Codes: T Toxic, N Dangerous for the environment.
RIDADR: 2761
RTECS: PC8575000
HazardClass: 6.1(b)
PackingGroup: III
Risk Statements: 24/25-40-50/53
R24/25: Toxic in contact with skin and if swallowed.
R40: Limited evidence of a carcinogenic effect.
R50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 22-36/37-45-60-61
S22: Do not breathe dust.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
S60: This material and/or its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions safety data sheet.
Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion, skin contact. Experimental teratogenic and reproductive effects. Mutation data reported. Inhalation, absorption, or ingestion by humans can lead to central nervous system, liver, and kidney damage, including bizarre symptoms caused by damage to the nervous system. Usually, the symptoms are tremors, ataxia, skin changes, hyperexcitability, hyperactivity, muscle spasms, testicular atrophy, low sperm count, estrogenic effects, sterility, breast enlargement, liver lesions, and cancer. An insecticide and fungicide. Registration suspended by the USEPA.

Standards and Recommendations

DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
NIOSH REL: (Kepone) CL 0.001 mg/m³/15M

Analytical Methods

For occupational chemical analysis use NIOSH: Kepone, 5508.

Specification

Kepone (143-50-0),which also can be called for 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2h-cyclobuta(cd)pe ; 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one ; 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro-octahydro-1,3,4-metheno-2h-cyclobuta[cd]pen ; 1,2,3,4,5,5,6,7,8,9,10,10-Dodecachlorooctahydro-1,3,4-metheno-2-cyclobuta-(c,d) ; 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup2,6).0(sup3,9).0(sup5,8))decan ; 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.02,6.03,9 .05,8)decan-4-one ; 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro- ; 1,3,4-Metheno-2h-cyclobuta(cd)pentalen-2-one,1,1a,3,3a,4,5,5,5a,5b,6-decachlor . Kepone (143-50-0) is an odorless colorless crystalline solid and it should be stored at 0℃-6℃. It's insoluble in water.