Basic information
- Name:
L-Leucine
- CAS No.:
61-90-5
- Molecular Structure:
- Formula:
- C6H13NO2
- Molecular Weight:
- 131.17
- Synonyms:
- L(+)-Leucine;.alpha.-Aminoisocaproic acid;2-Amino-4-methylpentanoic acid, (S)-;L-Norvaline, 4-methyl-;L-alpha-Aminoisocaproic acid;Leucine (USP);2-Amino-4-methylvaleric acid (L);(2S)-alpha-Leucine;Pentanoic acid, 2-amino-4-methyl-, (S)-;(S)-2-Amino-4-methyl-pentanoic acid;Leucine, L-;2-Amino-4-methylpentanoic acid;(S)-(+)-leucine;Pentanoic acid, 2-amino-4-methyl-;Leu;Valeric acid, 2-amino-4-methyl-, (S)-;(2S)-2-azaniumyl-4-methyl-pentanoate;(S)-2-Amino-4-methylvaleric acid;(2S)-2-amino-4-methylpentanoic acid;Norvaline, 4-methyl-;L-Leuzin;L-2-Amino-4-methylpentanoic acid;(2S)-alpha-2-Amino-4-methylvaleric acid;FEMA No. 3297;2-Amino-4-methylpentanoic acid (L);(S)-leucine;
- EINECS:
- 200-522-0
- Density:
- 1.036 g/cm3
- Melting Point:
- >300 °C(lit.)
- Boiling Point:
- 225.8 °C at 760 mmHg
- Flash Point:
- 90.3 °C
- Solubility:
- 22.4 g/L (20 °C) in water
- Appearance:
- White crystalline powder
- Safety Description:
- 24/25 Details
- particular:
- particular
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Chemistry
Structure of L-Leucine (CAS NO.61-90-5):
IUPAC Name: (2S)-2-amino-4-methylpentanoic acid
Empirical Formula: C6H13NO2
Molecular Weight: 131.1729
EINECS: 200-522-0
Index of Refraction: 1.462
Molar Refractivity: 34.86 cm3
Molar Volume: 126.6 cm3
Polarizability: 13.82×10-24cm3
Surface Tension: 39 dyne/cm
Density: 1.035 g/cm3
Flash Point: 90.3 °C
Enthalpy of Vaporization: 50.93 kJ/mol
Melting Point: >300 °C(lit.)
Boiling Point: 225.8 °C at 760 mmHg
Vapour Pressure: 0.0309 mmHg at 25°C
Solubility: 1 M HCl: 50 mg/mL
Water Solubility: 22.4 g/L (20 C)
Stability: Stability Moisture and light sensitive. Incompatible with strong oxidising agents.
Appearance: White crystalline powder
Product Categories: Food and Feed Additive;Amino Acid Derivatives;Leucine [Leu, L];Amino Acids;Amino Acids and Derivatives;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids
Synonyms of L-Leucine (CAS NO.61-90-5): (s)-2-amino-4-methylvalericacid;2-amino-4-methyl-valericaci;1-Leucine;2-Amino-4-methylpentanoic acid;2-amino-4-methylpentanoicacid;4-methyl-l-norvalin;4-methyl-norvalin;alpha-Amino-gamma-methylvaleric acid
Uses
L-Leucine (CAS NO.61-90-5) is used for pharmaceutical raw materials and food additives. As a food additive, it has E number E641 and is classified as a flavour enhancer.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rabbit | LDLo | subcutaneous | 2620mg/kg (2620mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 40, Pg. 313, 1898. | |
| rat | LD50 | intraperitoneal | 5379mg/kg (5379mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Safety Statements of L-Leucine (CAS NO.61-90-5): 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: OH2850000
HS Code: 29224995
Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.