Basic information
- Name:
L-Tryptophan
- CAS No.:
73-22-3
- Molecular Structure:
- Formula:
- C11H12N2O2
- Molecular Weight:
- 204.25
- Deleted CAS:
- 6912-86-3|80206-30-0
- Synonyms:
- L(-)-Tryptophan;EH 121;l-alpha-Aminoindole-3-propionic acid;(S)-alpha-Amino-beta-(3-indolyl)-propionic acid;Sedanoct;L-Tryptophan (JP14);L-Trp;(S)-alpha-Amino-beta-indolepropionic acid;NCI-C01729;(S)-2-Amino-3-(3-indolyl)propionic acid;(-)-Tryptophan;(S)-alpha-Aminoindole-3-propionic acid;(2S)-2-azaniumyl-3-(1H-indol-3-yl)propanoate;Tryptophan, L-;2-Amino-3-indolylpropanoic acid;WV;Pacitron;Indole-3-alanine;1H-Indole-3-propanoic acid, alpha-amino-, (S)-;(S)-Tryptophan;Alanine, 3-indol-3-yl;L-(-)-Tryptophan;Triptofano [Spanish];3-Indol-3-ylalanine;Ardeytropin;L-alpha-Amino-3-indolepropionic acid;(S)-alpha-Amino-1H-indole-3-propanoic acid;Tryptophan (VAN);alpha-Amino-3-indolepropionic acid, L-;Tryptophanum [Latin];L-Alanine, 3-(1H-indol-3-yl)-;L-Tryptophan (9CI);
- EINECS:
- 200-795-6
- Density:
- 1.363 g/cm3
- Melting Point:
- 289-290 °C (dec.)(lit.)
- Boiling Point:
- 447.908 °C at 760 mmHg
- Flash Point:
- 224.687 °C
- Solubility:
- 11.4 g/L (25°C) in water
- Appearance:
- White to off-white crystalline powder
- Hazard Symbols:
Xi- Risk Codes:
- 33-40-62-41-37/38-36/37/38-22
- Safety Description:
- 24/25-36/37/39-36-26 Details
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Chemistry
Molecular Structure of L-Tryptophan (CAS NO.73-22-3):
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IUPAC Name: 2-amino-3-(1H-indol-3-yl)propanoic acid
Molecular formula: C11H12N2O2
Molar mass: 204.23 g mol -1
H bond acceptors: 4
H bond donors: 4
Merck: 14,9797
BRN: 86197
Freely Rotating Bonds: 4
Polar Surface Area: 34.47Å2
Index of Refraction: 1.697
Molar Refractivity: 57.76 cm3
Molar Volume: 149.8 cm3
Surface Tension: 71.1 dyne/cm
Density: 1.362 g/cm3
Flash Point: 224.7 °C
Enthalpy of Vaporization: 74.44 kJ/mol
Boiling Point: 447.9 °C at 760 mmHg
Vapour Pressure: 8.3E-09 mmHg at 25°C
Water Solubility: 11.4 g/L (25°C)
Melting point: 289-290 °C (dec.)(lit.)
InChI
InChI=1/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
Smiles
c12c(C[C@@H](C(=O)O)N)c[nH]c1cccc2
EINECS: 200-795-6
Product Categories: Amino Acid Derivatives; Tryptophan [Trp, W]; Amino Acids; Amino Acids and Derivatives; alpha-Amino Acids; Biochemistry; Indoles; Tryptophans; Nutritional Supplements; L-Amino Acids; Amino Acids
Uses
L-Tryptophan (CAS NO.73-22-3) can be improvement nutrition and enhancement physique. It is also uses in the biochemistry research, and it is used as sedative in the medicine.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - domestic | LD50 | intraperitoneal | 2410mg/kg (2410mg/kg) | Drugs in Japan Vol. -, Pg. 744, 1990. | |
| man | TDLo | oral | 300mg/kg (300mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: ANTIANXIETY | British Medical Journal. Vol. 2, Pg. 701, 1976. |
| man | TDLo | oral | 857mg/kg/30D- (857mg/kg) | BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER MUSCULOSKELETAL: OTHER CHANGES | New England Journal of Medicine. Vol. 322, Pg. 874, 1990. |
| mouse | LD50 | intraperitoneal | 4800mg/kg (4800mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980. |
| mouse | LDLo | oral | 15gm/kg (15000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980. |
| rat | LD50 | intraperitoneal | 1634mg/kg (1634mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955. |
| rat | LD50 | oral | > 16gm/kg (16000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: COMA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980. |
| rat | LDLo | unreported | 2553mg/kg (2553mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 884, 1973. | |
| women | TDLo | oral | 2700mg/kg/13W (2700mg/kg) | LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: EOSINOPHILIA | Annals of Internal Medicine. Vol. 112, Pg. 301, 1990. |
| women | TDLo | oral | 3276mg/kg/9W- (3276mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Annals of Internal Medicine. Vol. 112, Pg. 344, 1990. |
| women | TDLo | oral | 4800mg/kg/34W (4800mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER BLOOD: EOSINOPHILIA | New England Journal of Medicine. Vol. 322, Pg. 874, 1990. |
| women | TDLo | oral | 5400mg/kg/134 (5400mg/kg) | BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER | New England Journal of Medicine. Vol. 322, Pg. 874, 1990. |
| women | TDLo | oral | 9gm/kg/22W-I (9000mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: EOSINOPHILIA | Annals of Internal Medicine. Vol. 112, Pg. 957, 1990. |
| women | TDLo | oral | 10960mg/kg/20 (10960mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: EOSINOPHILIA | British Medical Journal. Vol. 301, Pg. 21, 1990. |
Consensus Reports
NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-71 ,1978. . Reported in EPA TSCA Inventory.
Safety Profile
Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes of L-Tryptophan (CAS NO.73-22-3): 
Xi
Risk Statements: 33-40-62-41-37/38-36/37/38-22
R33: Danger of cumulative effects.
R40: Limited evidence of a carcinogenic effect.
R62: Risk of impaired fertility.
R41: Risk of serious damage to the eyes.
R37/38: Irritating to respiratory system and skin.
R36/37/38: Irritating to eyes, respiratory system and skin.
R22: Harmful if swallowed.
Safety Statements: 24/25-36/37/39-36-26
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S36: Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 2
RTECS: YN6130000
F: 8
HS Code: 29339990
Specification
L-Tryptophan , with CAS number of 73-22-3, can be called (S)-alpha-Amino-1H-indole-3-propanoic acid ; (S)-alpha-Aminoindole-3-propionic acid ; 1-beta-3-Indolylalanine ; 1H-Indole-3-alanine (VAN) ; 1H-Indole-3-propanoic acid, alpha-amino-, (S)- ; 2-Amino-3-indolylpropanoic acid . It is a white to off-white crystalline powder. L-Tryptophan (CAS NO.73-22-3) are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.