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LOPERAMIDE HYDROCHLORIDE

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Name LOPERAMIDE HYDROCHLORIDE EINECS 252-082-4
CAS No. 34552-83-5 Density ==
Solubility Melting Point 223-225 °C
Formula C29H33ClN2O2.HCl Boiling Point 647.2 °C at 760 mmHg
Molecular Weight 513.55 Flash Point 345.2 °C
Transport Information UN 2811 6.1/PG 3 Appearance White solid
Safety 45 Risk Codes 25
Molecular Structure Molecular Structure of 34552-83-5 (Loperamide hydrochloride) Hazard Symbols ToxicT
Synonyms

Imodium;1-Piperidinebutanamide,4-(4-chlorophenyl)-4- hydroxy-N,N-dimethyl-R,R-diphenyl-,monohydrochloride;Imodium (TN);Lopemin;Prestwick_302;4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide hydrochloride;R 18553;Loperamide hydrochloride (JAN/USP);Loperamide HCl;

 

Chemistry

The Molecular formula of LOPERAMIDE HYDROCHLORIDE(34552-83-5): C29H34Cl2N2O2
The Molecular Weight of LOPERAMIDE HYDROCHLORIDE(34552-83-5): 513.5
The Molecular Structure of LOPERAMIDE HYDROCHLORIDE(34552-83-5): 
EINECS: 252-082-4
Melting point: 223-225°C
Boiling Point: 647.2 °C at 760 mmHg  
Flash Point: 345.2 °C 
Enthalpy of Vaporization: 100.3 kJ/mol 
Vapour Pressure: 1.23E-17 mmHg at 25°C 
Appearance: White Solid
IUPAC Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Synonyms: 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINEBUTANAMIDE HYDROCHLORIDE;4-(4-chlorophenyl)-4-hydroxy-n,n-dimethyl-alpha,alpha-;LOPERAMIDE HYDROCHLORIDE;4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINBUTYRAMIDE HYDROCHLORIDE;LABOTEST-BB LT00134703;LOSERAMIN;LOPERAMIDE HCL;

Uses

LOPERAMIDE HYDROCHLORIDE(34552-83-5) is used as antidiarrheal drugs.

Toxicity Data With Reference

The Toxicity Information of  LOPERAMIDE HYDROCHLORIDE(34552-83-5):
1.   

orl-cld TDLo:125 µg/kg

   BMJOAE    British Medical Journal. 294 (1987),1383.
2.   

orl-rat LD50:185 mg/kg

   JMCMAR    Journal of Medicinal Chemistry. 16 (1973),782.
3.   

scu-rat LD50:78,700 µg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913.
4.   

ivn-rat LD50:7490 µg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913.
5.   

orl-mus LD50:105 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 24 (1974),1633.
6.   

ipr-mus LD50:28 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 24 (1974),1633.
7.   

scu-mus LD50:75 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 24 (1974),1636.
8.   

ivn-mus LD50:12,600 µg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913.
9.   

orl-gpg LD50:41,500 µg/kg

   IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),1204.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl, NOx, and HCl.}
The Hazard Codes of LOPERAMIDE HYDROCHLORIDE(34552-83-5):  T
HazardClass: 6.1(b)
The Risk Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
25:  Toxic if swallowed
The Safety Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TM4960000
PackingGroup: III

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