Basic information
- Name:
Loperamide hydrochloride
- CAS No.:
34552-83-5
- Molecular Structure:
- Formula:
- C29H33ClN2O2.HCl
- Molecular Weight:
- 513.55
- Synonyms:
- Imodium;1-Piperidinebutanamide,4-(4-chlorophenyl)-4- hydroxy-N,N-dimethyl-R,R-diphenyl-,monohydrochloride;Imodium (TN);Lopemin;Prestwick_302;4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide hydrochloride;R 18553;Loperamide hydrochloride (JAN/USP);Loperamide HCl;
- EINECS:
- 252-082-4
- Melting Point:
- 223-225 °C
- Boiling Point:
- 647.2 °C at 760 mmHg
- Flash Point:
- 345.2 °C
- Appearance:
- White solid
- Hazard Symbols:
T- Risk Codes:
- 25
- Safety Description:
- 45 Details
- Transport Information:
- UN 2811 6.1/PG 3
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Chemistry
The Molecular formula of LOPERAMIDE HYDROCHLORIDE(34552-83-5): C29H34Cl2N2O2
The Molecular Weight of LOPERAMIDE HYDROCHLORIDE(34552-83-5): 513.5
The Molecular Structure of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
EINECS: 252-082-4
Melting point: 223-225°C
Boiling Point: 647.2 °C at 760 mmHg
Flash Point: 345.2 °C
Enthalpy of Vaporization: 100.3 kJ/mol
Vapour Pressure: 1.23E-17 mmHg at 25°C
Appearance: White Solid
IUPAC Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Synonyms: 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINEBUTANAMIDE HYDROCHLORIDE;4-(4-chlorophenyl)-4-hydroxy-n,n-dimethyl-alpha,alpha-;LOPERAMIDE HYDROCHLORIDE;4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINBUTYRAMIDE HYDROCHLORIDE;LABOTEST-BB LT00134703;LOSERAMIN;LOPERAMIDE HCL;
The Molecular Weight of LOPERAMIDE HYDROCHLORIDE(34552-83-5): 513.5
The Molecular Structure of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
EINECS: 252-082-4
Melting point: 223-225°C
Boiling Point: 647.2 °C at 760 mmHg
Flash Point: 345.2 °C
Enthalpy of Vaporization: 100.3 kJ/mol
Vapour Pressure: 1.23E-17 mmHg at 25°C
Appearance: White Solid
IUPAC Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Synonyms: 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINEBUTANAMIDE HYDROCHLORIDE;4-(4-chlorophenyl)-4-hydroxy-n,n-dimethyl-alpha,alpha-;LOPERAMIDE HYDROCHLORIDE;4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINBUTYRAMIDE HYDROCHLORIDE;LABOTEST-BB LT00134703;LOSERAMIN;LOPERAMIDE HCL;
Uses
LOPERAMIDE HYDROCHLORIDE(34552-83-5) is used as antidiarrheal drugs.
Toxicity Data With Reference
The Toxicity Information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
| 1. | orl-cld TDLo:125 µg/kg | BMJOAE British Medical Journal. 294 (1987),1383. | ||
| 2. | orl-rat LD50:185 mg/kg | JMCMAR Journal of Medicinal Chemistry. 16 (1973),782. | ||
| 3. | scu-rat LD50:78,700 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
| 4. | ivn-rat LD50:7490 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
| 5. | orl-mus LD50:105 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1633. | ||
| 6. | ipr-mus LD50:28 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1633. | ||
| 7. | scu-mus LD50:75 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1636. | ||
| 8. | ivn-mus LD50:12,600 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
| 9. | orl-gpg LD50:41,500 µg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),1204. |
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and HCl.}
The Hazard Codes of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
T
HazardClass: 6.1(b)
The Risk Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
25: Toxic if swallowed
The Safety Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TM4960000
PackingGroup: III
The Hazard Codes of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
T HazardClass: 6.1(b)
The Risk Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
25: Toxic if swallowed
The Safety Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TM4960000
PackingGroup: III