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Lactic acid

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Name

Lactic acid

EINECS 200-018-0
CAS No. 50-21-5 Density 1.277 g/cm3
PSA 57.53000 LogP -0.54820
Solubility Soluble in water Melting Point 18 °C
Formula C3H6O3 Boiling Point 227.561 °C at 760 mmHg
Molecular Weight 90.0788 Flash Point 109.936 °C
Transport Information UN 1760 Appearance colourless to yellow liquid
Safety 26-39-45-36/37/39 Risk Codes 38-41-34
Molecular Structure Molecular Structure of 50-21-5 (Lactic acid) Hazard Symbols IrritantXi, CorrosiveC
Synonyms

DL-Milchsaeure;Propanoic acid, 2-hydroxy-;2-Hydroxy-2-methylacetic acid;Aethylidenmilchsaeure;Purac FCC 88;2-Hydroxypropionic acid;Tonsillosan;Racemic lactic acid;Milk acid;alpha-Hydroxypropanoic acid;FEMA No. 2611;Chem-Cast;Lactovagan;Lactate (TN);2-hydroxypropanoic acid;(RS)-2-Hydroxypropionsaeure;Propanoic acid, 2-hydroxy- (9CI);(+-)-2-Hydroxypropanoic acid;Fermentationlactic acid Propanoic acid,2-hydroxy-;SY-83;Ordinary lactic acid;Biolac;Acidum lacticum;Lactic acid (7CI,8CI);alpha-hydroxypropionic acid;Milchsaeure;1-Hydroxyethanecarboxylic acid;

Article Data 3

Lactic acid Chemical Properties

Structure of Lactic acid (CAS NO.50-21-5):

IUPAC Name: 2-hydroxypropanoic acid 
Empirical Formula: C3H6O3
Molecular Weight: 90.0779g/mol
EINECS: 200-018-0 
Index of Refraction: 1.451
Molar Refractivity: 19 cm3
Molar Volume: 70.5 cm3
Polarizability: 7.53×10-24cm3
Surface Tension: 49.7 dyne/cm
Density: 1.276 g/cm3
Flash Point: 109.9 °C
Enthalpy of Vaporization: 53.96 kJ/mol 
Melting point: 18 ºC
Boiling Point: 227.6 °C at 760 mmHg
Vapour Pressure: 0.015 mmHg at 25°C 
Product Categories: FOOD ADDITIVES;Plant Growth Regulator;Food & Feed ADDITIVES;ACS GradeChiral Building Blocks;Carboxylic Acids;Essential Chemicals;Organic Building Blocks;Routine Reagents;Food & Flavor Additives 
Canonical SMILES: CC(C(=O)O)O
InChI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)
InChIKey: JVTAAEKCZFNVCJ-UHFFFAOYSA-N

Lactic acid Production

Commercially, lactic acid (CAS NO.50-21-5) is manufactured by controlled fermentation of the hexose sugars from molasses, corn, or milk. Lactates are made by synthetic methods from acetaldehyde and lactonitrile, a by-product acrylonitrile production.

Lactic acid Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 1810mg/kg (1810mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
mouse LD50 oral 4875mg/kg (4875mg/kg)   FAO Nutrition Meetings Report Series. Vol. 40, Pg. 144, 1967.
quail LD50 oral > 2250mg/kg (2250mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C252, 1991.
rabbit LD50 skin > 2gm/kg (2000mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C252, 1991.
rabbit LDLo oral 5gm/kg (5000mg/kg)   Industrial and Engineering Chemistry. Vol. 15, Pg. 628, 1923.
rabbit LDLo rectal 600mg/kg (600mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 83, Pg. 136, 1920.
rat LD50 oral 3543mg/kg (3543mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C252, 1991.

Lactic acid Consensus Reports

Reported in EPA TSCA Inventory.

Lactic acid Safety Profile

Hazard Codes: IrritantXi,CorrosiveC
Risk Statements: 38-41-34 
R38: Irritating to skin. 
R41: Risk of serious damage to the eyes. 
R34: Causes burns.
Safety Statements: 26-39-45-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S39: Wear eye / face protection. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 3265
WGK Germany: 2
RTECS: OD2800000
F: 3
HazardClass: 8
PackingGroup: III
Moderately toxic by ingestion and rectal routes. Mutation data reported. A severe skin and eye irritant. Mixtures with nitric acid + hydrofluoric acid may react vigorously and are storage hazards. When heated to decomposition it emits acrid smoke and irritating fumes.

Lactic acid Specification

   Lactic acid , its cas register number is 50-21-5. It also can be called (RS)-2-Hydroxypropionsaeure ; 1-Hydroxyethanecarboxylic acid ; 2-Hydroxypropanoic acid ; Acidum lacticum ; Aethylidenmilchsaeure ; DL-Lactic acid ; DL-Milchsaeure ; Ethylidenelactic acid ; Kyselina 2-hydroxypropanova ; Kyselina mlecna ; Lactate ; Lactovagan ; Milchsaeure ;
 Milchsaure ; Milk acid ; Ordinary lactic acid ; Propionic acid, 2-hydroxy- ; Racemic lactic acid ; Tonsillosan ; alpha-Hydroxypropionic acid . Lactic acid (CAS NO.50-21-5) is a colourless to yellow liquid.

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