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Lasiocarpine

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Name

Lasiocarpine

EINECS N/A
CAS No. 303-34-4 Density 1.21g/cm3
PSA 105.53000 LogP 0.89670
Solubility

Stability

    Stable, but is readily hydrolyzed in basic solution and readily oxidized by oxidizing agents. Reacts slowly with atmospheric oxygen.

Toxicology

    Poison. Experimental carcinogen. Possible human ca
Melting Point 97 C
Formula C21H33 N O7 Boiling Point 519.8°Cat760mmHg
Molecular Weight 411.55 Flash Point 268.1°C
Transport Information N/A Appearance colourless to beige crystalline solid
Safety Suspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, intraperitoneal, and parenteral routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS. Risk Codes N/A
Molecular Structure Molecular Structure of 303-34-4 (lasiocarpine) Hazard Symbols N/A
Synonyms

2-Butenoicacid, 2-methyl-,7-[[2,3-dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-ylester, [1S-[1a(Z),7[S*(R*)],7aa]]-; Lasiocarpine (6CI,7CI,8CI);(-)-Lasiocarpine; 7-Angelyleuropine; Europine 7-angelate; NSC 30625

 

Lasiocarpine Chemical Properties

IUPAC Name: [(7S,8R)-7-[(Z)-2-Methylbut-2-enoyl]oxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2,3-dihydroxy-2-[(1S)-1-methoxyethyl]-3-methylbutanoate
Molecular Formula: C21H33NO7
Molecular Weight: 411.55g/mol
Freely Rotating Bonds: 12
Polar Surface Area: 83.53 Å2
Index of Refraction: 1.544
Molar Refractivity: 106.91 cm3
Molar Volume: 338.2 cm3
Polarizability: 42.38 ×10-24cm3
Surface Tension: 49.7 dyne/cm
Density: 1.21 g/cm3
Flash Point: 268.1 °C
Enthalpy of Vaporization: 91.21 kJ/mol
Boiling Point: 519.8 °C at 760 mmHg
Vapour Pressure: 5.63E-13 mmHg at 25°C 
The Cas Register Number of Lasiocarpine is 303-34-4 .The chemical synonyms of Lasiocarpine (CAS No. 303-34-4) are Lasiocarpine ; 2-Butenoic acid, 2-methyl-, 7[[(2,3-dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy] methyl]-2,3,5,7a-tetrahydro-1h-prrolizin-1-yl ester, [1s-[1alpha(z), 7(2s*, 3r*), 7aalpha)]- ; (Z)-2-Methyl-2-butenoic acid (1s)-7-[[[(2r)-2,3-dihydroxy-2-[(s)-1-methoxyethyl]-3-methylbutanoyl]oxy]methyl]-2,3,5,7aβ-tetrahydro-1h-pyrrolizin-1-yl ester .The molecular structure of Lasiocarpine (CAS No. 303-34-4) is.

Lasiocarpine Toxicity Data With Reference

1.    

sln-dmg-orl 750 ppm

    ENMUDM    Environmental Mutagenesis. 7 (1985),349.
2.    

trn-dmg-orl 750 ppm

    ENMUDM    Environmental Mutagenesis. 7 (1985),349.
3.    

orl-rat TDLo:255 mg/kg/2Y-C:CAR

    NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-39 ,1978.
4.    

ipr-rat TDLo:470 mg/kg/56W-I:CAR

    CNREA8    Cancer Research. 32 (1972),908.
5.    

orl-rat LD50:110 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 17 (1970),290.
6.    

ipr-rat LD50:78 mg/kg

    CNREA8    Cancer Research. 32 (1972),908.
7.    

ivn-rat LD50:88 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179.
8.    

par-rat LD50:80 mg/kg

    NATUAS    Nature. 223 (1969),1269.
9.    

ivn-mus LDLo:85 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179.
10.    

ivn-mky LDLo:20 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179.

Lasiocarpine Consensus Reports

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 , 1976,p. 281.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-39 ,1978. . EPA Genetic Toxicology Program.

Lasiocarpine Safety Profile

Suspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, intraperitoneal, and parenteral routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

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