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Basic information

  • Name:

  • Laurocapram

  • CAS No.:

  • 59227-89-3

  • Formula:
  • C18H35NO
  • Synonyms:
  • Laurocapramum;1-Dodecylazepan-2-one;2H-Azepin-2-one,1-dodecylhexahydro-;1-Dodecylazacycloheptan-2-one;2H-Azepin-2-one, 1-dodecylhexahydro-;N-Lauryl caprolactam;N 0252;Tranzone;1-Dodecyl azacyclohepta-2-one;N-Dodecylcaprolactam;Laurocapram Azone;

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Chemistry

IUPAC Name: 1-Dodecylazepan-2-one
Synonyms of Laurocapram (CAS NO.59227-89-3): 1-Dodecylazacycloheptan-2-one ; 1-Dodecylhexahydro-2H-azepin-2-one ; Azone ; Laurocapramum ; N-Lauryl caprolactam ; 2H-Azepin-2-one, 1-dodecylhexahydro- ; 2H-Azepin-2-one, hexahydro-N-lauryl- ; N-Dodecylcaprolactam
CAS NO: 59227-89-3
Molecular Formula: C18H35NO
Molecular Weight: 281.48
Molecular Structure:
EINECS: 261-668-9
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 11
Polar Surface Area: 20.31 Å2
Index of Refraction: 1.465
Molar Refractivity: 87.02 cm3
Molar Volume: 314.3 cm3
Surface Tension: 32.9 dyne/cm
Density: 0.895 g/cm3
Flash Point: 165.2 °C
Enthalpy of Vaporization: 65.64 kJ/mol
Boiling Point: 404.9 °C at 760 mmHg
Vapour Pressure: 9.12E-07 mmHg at 25°C
Appearance: Colorless or yellowish transparent liquid
Solubility: Insoluble in water, and form emulsions with water, soluble in various organic solvents.
SMILES: O=C1N(CCCCCCCCCCCC)CCCCC1
InChI: InChI=1/C18H35NO/c1-2-3-4-5-6-7-8-9-10-13-16-19-17-14-11-12-15-18(19)20/h2-17H2,1H3
InChIKey: AXTGDCSMTYGJND-UHFFFAOYAS
Std. InChI: InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-13-16-19-17-14-11-12-15-18(19)20/h2-17H2,1H3
Std. InChIKey: AXTGDCSMTYGJND-UHFFFAOYSA-N
Product Categories of Laurocapram (CAS NO.59227-89-3): ketone

Uses

 Laurocapram (CAS NO.59227-89-3) is used as the penetration enhancer in cosmetic preparations and personal-care products. Laurocapram is combined as an excipient not an active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients long enough to be active until internal use. Excipients are combined also to support the active ingredients, so that the latter can be easily administered or absorbed in the body.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 intravenous 8gm/kg (8000mg/kg)   Drug Development and Industrial Pharmacy. Vol. 9, Pg. 725, 1983.
mouse LD50 skin 8gm/kg (8000mg/kg)   Drug Development and Industrial Pharmacy. Vol. 9, Pg. 725, 1983.
rat LD50 intraperitoneal 8gm/kg (8000mg/kg)   Drug Development and Industrial Pharmacy. Vol. 9, Pg. 725, 1983.
rat LD50 intravenous 8gm/kg (8000mg/kg)   Drug Development and Industrial Pharmacy. Vol. 9, Pg. 725, 1983.
rat LD50 oral > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. 4882359,
rat LD50 skin 8gm/kg (8000mg/kg)   Drug Development and Industrial Pharmacy. Vol. 9, Pg. 725, 1983.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. 4882359,
rat LD50 unreported 8gm/kg (8000mg/kg)   Archives of Dermatology. Vol. 118, Pg. 474, 1982.

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