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Basic information

  • Name:

  • Leflunomide

  • CAS No.:

  • 75706-12-6

  • Formula:
  • C12H9F3N2O2
  • Synonyms:
  • 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-;N-(4-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide;Leflunomidum [INN-Latin];sell leflunomide;5-methyl-N-[4-(trifluoromethyl)phenyl]oxazole-4-carboxamide;5-Methylisoxazole-4-(4-trifluoromethyl) carboxanilide;Leflunamide;Isoxazole-4-carboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-;5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide;Arava;Leflunomida [INN-Spanish];

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Chemistry

Molecular structure of Leflunomide (CAS NO.75706-12-6) is:

Product Name: Leflunomide
CAS Registry Number: 75706-12-6
IUPAC Name: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Molecular Weight: 270.20727 [g/mol]
Molecular Formula: C12H9F3N2O2
XLogP3-AA: 2.5
H-Bond Donor: 1
H-Bond Acceptor: 6 
Storage temp.: 2-8°C
Melting Point: 163-168°C
Surface Tension: 40.5 dyne/cm
Density: 1.392 g/cm3
Flash Point: 128.8 °C
Enthalpy of Vaporization: 52.86 kJ/mol
Boiling Point: 289.3 °C at 760 mmHg
Vapour Pressure: 0.00222 mmHg at 25°C
Product Categories: Active Pharmaceutical Ingredients;API;Osteoarthritis and Rheumatoid Arthritis;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling

Uses

 Leflunomide (CAS NO.75706-12-6) is used in active moderate to severe rheumatoid arthritis and psoriatic arthritis.It is an immunomodulatory drug inhibiting dihydroorotate dehydrogenase.It can relieve symptoms of rheumatoid arthritis and psoriatic arthritis.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 185mg/kg (185mg/kg)   United States Patent Document. Vol. #5494911,
mouse LD50 oral 445mg/kg (445mg/kg)   United States Patent Document. Vol. #5494911,
rat LD50 intraperitoneal 170mg/kg (170mg/kg)   United States Patent Document. Vol. #5494911,
rat LD50 oral 235mg/kg (235mg/kg)   United States Patent Document. Vol. #5494911,

Safety Profile

Hazard Codes: HarmfulXn,Xi
Risk Statements: 22-36/37/38 
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
 S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: NY2354200

Specification

 Leflunomide , its cas register number is 75706-12-6. It also can be called 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)- ; 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide ; 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide ; Arava ; Leflunomida ; Leflunomidum ; N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide ; alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide .It is a off white crystalline solid.

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