Levocetirizine (130018-77-8),Levocetirizine (130018-77-8) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Levocetirizine
CAS No.:
130018-77-8
Molecular Structure:
Formula:
C₂₁H₂₅ClN₂O₃
Molecular Weight:
388.89
Synonyms:
Aceticacid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, (R)-;Aceticacid, [2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- (9CI);(-)-Cetirizine;(R)-Cetirizine;Acetic acid,2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-;
Density:
1.237 g/cm³
Boiling Point:
542.1 °C at 760 mmHg
Flash Point:
281.6 °C

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Chemistry

IUPAC Name: 2-[2-[4-[(R)-(4-Chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
Empirical Formula: C₂₁H₂₅ClN₂O₃
Molecular Weight: 388.8878
Canonical SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
Isomeric SMILES: C1CN(CCN1CCOCC(=O)O)[C@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1
InChIKey: ZKLPARSLTMPFCP-OAQYLSRUSA-N
Index of Refraction: 1.589
Molar Refractivity: 105.94 cm³
Molar Volume: 314.2 cm³
Surface Tension: 50.7 dyne/cm
Density: 1.237 g/cm³
Flash Point: 281.6 °C
Enthalpy of Vaporization: 86.31 kJ/mol
Boiling Point: 542.1 °C at 760 mmHg
Vapour Pressure: 1.39E-12 mmHg at 25 °C
Classification Code of Levocetirizine (CAS NO.130018-77-8): Antihistamine; Histamine Agents; Histamine Antagonists; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Neurotransmitter Agents

History

Levocetirizine (CAS NO.130018-77-8) was first launched in 2001 by Belgian pharmaceutical company UCB with the brand name Xyzal (pronounced /?za?zæl/) in Austria, Finland, France, Ireland, Netherlands, Portugal, Romania, United States, UK; Xuzal in Mexico; Xusal in Germany; and Xozal in Greece. In India, levocetirizine is marketed by GlaxoSmithKline under the brand name Vozet and Xyzal. On May 25, 2007, the United States Food and Drug Administration approved Xyzal, where it is co-marketed by Sanofi-Aventis.Torrent Pharma launched UVNIL in rural market of INDIA. It is also available as LEZYNCET 5 mg tablets through Unichem in India. In India, generic name of Lev-Cit 5mg is manufactured by VIP Pharmaceuticals. Also marketed in India by Croslands (Ranbaxy Laboratories Ltd.) under the brand name Teczine. It is marked in Egypt by BORG Pharma under the brand name 'Xaltec', Allear by western pharmaceuticals and levcet by marcryl.

Uses

Levocetirizine is called a non-sedating antihistamine as it does not enter the brain in significant amounts, and is therefore unlikely to cause drowsiness. However, some people may experience some slight sleepiness, headache, mouth dryness, lightheadedness, vision problems (mainly blurred vision), palpitations and fatigue.

Specification

Levocetirizine (CAS NO.130018-77-8), its Synonyms are (-)-Cetirizine ; (2-(4-((R-p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic acid ; Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)- ; Xusal .