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Name	Liothyronine sodium	EINECS	200-223-5
CAS No.	55-06-1	Density	N/A
PSA	95.61000	LogP	3.31830
Solubility	Partly miscible in water. Soluble in dimethyl sulfoxide, methanol, sodium hydroxide and ethanol. Practically insoluble in most other organic solvents.	Melting Point	205 °C (dec.)(lit.)
Formula	C₁₅H₁₁I₃NNaO₄	Boiling Point	563.5 °C at 760 mmHg
Molecular Weight	672.96	Flash Point	294.6 °C
Transport Information	N/A	Appearance	white to beige powder
Safety	22-24/25-36	Risk Codes	20/21/22
Molecular Structure		Hazard Symbols	Xn
Synonyms	Alanine,3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, monosodium salt, L- (8CI);L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (9CI);3,3',5-Triiodo-L-thyronine sodium salt;3,3',5-Triiodothyronine sodium salt;3,5,3'-Triiodo-L-thyronine monosodium salt;Basoprocin;Cynomel;Cyomel;Cytobin;Cytomel;Cytomel sodium;Cytomine;Ibiothyron;L-Triiodothyroninesodium salt;Liothyroniinde sodium salt;Liothyroninesodium;Sodium 3,3',5-triiodo-L-thyronine;Sodium 3,5,3'-triiodothyronine;Sodium L-3,3',5-triiodothyronine;Sodium L-triiodothyronine;Sodium T3;Sodiumliothyronine;Sodium triiodo-L-thyronine;Sodium triiodothyronine;T3 Sodiumsalt;Tertroxin;Triiodothyronine sodium salt;Triostat;Triothyrone;	Article Data	1

Liothyronine sodium Synthetic route

: 1041-01-6, 534-51-0, 5563-89-3, 299-82-1
3,5-diiodo-L-thyronine

: 55-06-1
liothyronine sodium

Conditions

Conditions	Yield
With iodine; ethylamine; sodium iodide In water at 0 - 22℃; for 7h; Large scale;

: bismuth (III) nitrate pentahydrate

: 55-06-1
liothyronine sodium

: bismuth triiodothyronine

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 18h;	91%

: 55-06-1
liothyronine sodium

: 1417654-45-5
(S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)-2-iodophenol

Conditions

Conditions	Yield
With lithium borohydride; chloro-trimethyl-silane In tetrahydrofuran; 1,4-dioxane at 0℃; Inert atmosphere;	61%

: 55-06-1
liothyronine sodium

: 3,5-diiodo-N-[[(carboxymethyl)[2-[(carboxymethyl)[2-[bis(carboxymethyl)amino]ethyl]amino]ethyl]amino]acetyl]-O-[3-iodo-4-(sulfooxy)phenyl]-l-tyrosine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic acid / water / Large scale 2.1: chlorosulfonic acid / N,N-dimethyl acetamide / 4.67 h / -5 - 5 °C / Inert atmosphere 2.2: 1.5 h / Inert atmosphere 3.1: N,N-dimethyl acetamide; water / 4.5 h / 80 °C 3.2: 0.33 h / 25 °C View Scheme

: 55-06-1
liothyronine sodium

: 6893-02-3
triiodothyronine

Conditions

Conditions	Yield
With acetic acid In water Large scale;

: 55-06-1
liothyronine sodium

: C36H47I3N4O14S2

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic acid / water / Large scale 2.1: chlorosulfonic acid / N,N-dimethyl acetamide / 4.67 h / -5 - 5 °C / Inert atmosphere 2.2: 1.5 h / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0 - 20 °C View Scheme

Liothyronine sodium Chemical Properties

IUPAC Name: Sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
Molecular Formula: C₁₅H₁₁I₃NNaO₄
Molecular Weight: 672.96 g/mol
SMILES: c1(Oc2cc(c(O)cc2)I)c(cc(C[C@@H](C(=O)[O-])N)cc1I)I.[Na+]
InChI: InChI=1/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
EINECS: 200-223-5
Classification Code: Thyroid hormone
Solubility: 4 M NH₄OH in methanol: 125 g/5mL, clear, yellow-brown
H-Bond Donor: 2
H-Bond Acceptor: 5
Flash Point: 294.6 °C
Enthalpy of Vaporization: 89.1 kJ/mol
Boiling Point: 563.5 °C at 760 mmHg
Melting Point: 205 °C (dec.)(lit.)
alpha: 20 °(c=2,alcohol/1.2N HCl)
Storage temperature: 2-8 °C
Vapour Pressure of Liothyronine sodium (CAS NO.55-06-1): 1.55E-13 mmHg at 25 °C

Liothyronine sodium Uses

Liothyronine sodium (CAS NO.55-06-1) used to treat hypothyroidism and myxedema coma.

Liothyronine sodium Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-24/25-36
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.
WGK Germany of Liothyronine sodium (CAS NO.55-06-1): 3

Liothyronine sodium Specification

Liothyronine sodium (CAS NO.55-06-1), its Synonyms are Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, monosodium salt, L- (8CI) ; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt ; 3,3',5-Triiodo-L-thyronine sodium ' 3,3',5-Triiodo-L-thyronine sodium salt ; 3,3',5-Triiodothyronine sodium salt ; Basoprocin ; Cynomel ; Monosodium L-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine ; Sodium 3,3',5-triiodo-L-thyronine ; Sodium 3,5,3'-triiodo-L-thyronine . It is white to beige powder.

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