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Basic information

  • Name:
  • Acetic acid, lithiumsalt (1:1)

  • Superlist Name:
  • Lithium acetate
  • CAS No.:
  • 546-89-4

  • Molecular Structure:
  • Formula:
  • C2H3LiO2
  • Molecular Weight:
  • 65.98
  • Synonyms:
  • Aceticacid, lithium salt (8CI,9CI);Lithium acetate (6CI);Lithium ethanoate;Quilone;Quilonorm;Quilonum;
  • EINECS:
  • 208-914-3
  • Melting Point:
  • 280-285 °C
  • Boiling Point:
  • 117.1 °C at 760 mmHg
  • Flash Point:
  • 40 °C
  • Solubility:
  • H2O: 5 M at 20 °C, clear, colorless
  • Appearance:
  • solid
  • Hazard Symbols:
  • IrritantXi
  • Risk Codes:
  • 36
  • Safety Description:
  • 23-24/25-39-26-22 Details

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Consensus Reports

Reported in EPA TSCA Inventory.

Standards and Recommendations

DOT Classification:  4.2; Label: Spontaneously Combustible

Specification

The Lithium acetate, with the CAS registry number 546-89-4, is also known as Acetic acid, lithium salt (1:1). It belongs to the product categories of Organic-Metal Salt; Lithium Compounds; Classes of Metal Compounds; Li (Lithium) Compounds; Typical Metal Compounds; LithiumMicro/Nanoelectronics; Inorganic Salts; Lithium; Solution Deposition Precursors; Synthetic Reagents. Its EINECS registry number is 208-914-3. This chemical's molecular formula is C2H3LiO2 and molecular weight is 65.99. Its IUPAC name is called lithium acetate. Lithium acetate is used in the laboratory as buffer for gel electrophoresis of DNA and RNA.

Physical properties of Lithium acetate: (1)ACD/LogP: -0.29; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.07; (4)ACD/LogD (pH 7.4): -2.86; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 2.73; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)Flash Point: 40 °C; (12)Enthalpy of Vaporization: 23.7 kJ/mol; (13)Boiling Point: 117.1 °C at 760 mmHg; (14)Vapour Pressure: 13.9 mmHg at 25°C.

Uses of Lithium acetate: it can be used to produce trans-4-Acetoxy-3-bromo-1,2,3,4-tetrahydroacridine. This reaction will need reagent N-bromoacetamide and solvent acetic acid. The reaction time is 4 hours at ambient temperature. The yield is about 85%.

Lithium acetate can be used to produce trans-4-Acetoxy-3-bromo-1,2,3,4-tetrahydroacridine

Uses of Lithium acetate: Lithium acetate is used in the laboratory as buffer for gel electrophoresis of DNA and RNA. It has a lower electrical conductivity and can be run at higher speeds than can gels made from TAE buffer (5-30V/cm as compared to 5-10V/cm). Lithium boric acid or sodium boric acid are usually preferable to lithium acetate or TAE when analyzing smaller fragments of DNA (less than 500 bp) due to the higher resolution of borate-based buffers in this size range as compared to acetate buffers. Lithium acetate is also used to permeabilize the cell wall of yeast for use in DNA transformation.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes. You should not breathe its gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer). What's more, you must avoid contact with skin and eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Wear eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: [Li+].CC(=O)[O-]
(2)InChI: InChI=1S/C2H4O2.Li/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
(3)InChIKey: XIXADJRWDQXREU-UHFFFAOYSA-M

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo oral 1500mg/kg (1500mg/kg)   Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 419, 1958.
mouse LDLo subcutaneous 1500mg/kg (1500mg/kg)   Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 419, 1958.

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