Basic information
- Name:
Lomefloxacin hydrochloride
- CAS No.:
98079-52-8
- Molecular Structure:
- Formula:
- C17H20ClF2N3O3
- Molecular Weight:
- 387.81
- Synonyms:
- 3-Quinolinecarboxylicacid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,monohydrochloride (9CI);Alkaflox;Bareon;Chimono;Lomebact;3-Quinolinecarboxylicacid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1);Lomflox;Lomitas;Lomoxin;Maxaquin;Mazaquin;Orchacin;Uniquin;
- Melting Point:
- 290-300 °C
- Boiling Point:
- 542.7 °C at 760 mmHg
- Flash Point:
- 282 °C
- Appearance:
- White powder with no smell, bitter taste
- Hazard Symbols:
Xn- Risk Codes:
- 22
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Chemistry
IUPAC Name: 1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride
Molecular Formula: C17H20ClF2N3O3
Molecular Weight: 387.808806 g/mol
H-Bond Donor: 3
H-Bond Acceptor: 8
Canonical SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
InChI: InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
Classification Code: Antibacterial; Drug / Therapeutic Agent; Reproductive Effect
Product Categories: Antibiotics for Research and Experimental Use;Biochemistry; Quinolones (Antibiotics for Research and Experimental Use); Intermediates & Fine Chemicals; Pharmaceuticals; Lomefloxacin
Flash Point: 282 °C
Melting Point: 290-300 °C
Boiling Point: 542.7 °C at 760 mmHg
Enthalpy of Vaporization: 86.39 kJ/mol
Vapour Pressure: 1.31E-12 mmHg at 25 °C
Storage Temperatureof Lomefloxacin hydrochloride (CAS NO.98079-52-8): -20 °C
Uses
Lomefloxacin hydrochloride (CAS NO.98079-52-8) is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 50mg/kg (50mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1288, 1990. | |
| mouse | LD50 | intravenous | 253mg/kg (253mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Suppl, |
| mouse | LD50 | oral | 1608mg/kg (1608mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Suppl, |
| mouse | LD50 | subcutaneous | 995mg/kg (995mg/kg) | Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. Vol. 19, Pg. 154, 1994. | |
| rat | LD50 | intravenous | 328mg/kg (328mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Suppl, |
| rat | LD50 | oral | 1556mg/kg (1556mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Suppl, |
| rat | LD50 | subcutaneous | 1637mg/kg (1637mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Chemotherapy Vol. 36(Supp |
Safety Profile
Hazard Codes: 
Xn
Risk Statements: 22
R22:Harmful if swallowed.
WGK Germany: 3
RTECS of Lomefloxacin hydrochloride (CAS NO.98079-52-8): VB1997500
Specification
Lomefloxacin hydrochloride (CAS NO.98079-52-8), its Synonyms are (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride ; Bareon ; Lomefloxacin HCl ; Maxaquin ; 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride ; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, (+-)- . It is white powder with no smell, bitter taste.