Loratadine (79794-75-5)

Molecular structure:

Formula :C₂₂H₂₃ClN₂O₂ 
Mol. mass: 382.88 g/mol 
Nominal Mass: 382 Da
Average Mass: 382.8832 Da
Monoisotopic Mass: 382.144806 Da 
Index of Refraction: 1.614
Molar Refractivity: 105.85 cm³
Molar Volume: 303.5 cm³
Surface Tension: 53.3 dyne/cm
Density: 1.261 g/cm³
Flash Point: 275.1 °C
Enthalpy of Vaporization: 80.68 kJ/mol
Boiling Point: 531.3 °C at 760 mmHg 
Melting Point: 134-136°C
Vapour Pressure: 2.26E-11 mmHg at 25°C
Storage temp: 2-8°C
Solubility DMSO: 26 mg/mL, soluble 
Appearance: White Crystalline Solid
InChI=1/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
Smiles
C1(\c2c(cc(Cl)cc2)CCc2c1nccc2)=C1\CCN(C(OCC)=O)CC1
IUPAC name : Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidine)-1-piperidinecarboxylate  
Synonyms of Loratadine (CAS NO.79794-75-5):  Loratadine ; Loratadine-d5 ; Loratidine ; Claratyne ; Claritin ; Ethyl 4-(8-chloro-5,6-dihydro-11h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate ; 4(8-Chloro-5,6-dihydro-11h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate ; 4-(8-Chloro-5,6-dihydro-11h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester   
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Histamine receptor

 Loratadine (CAS NO.79794-75-5) was eventually approved by the FDA.

 Loratadine (CAS NO.79794-75-5) is an antihistamine drug used to treat allergies.

Hazard Codes: Xi
Risk Statements of Loratadine (CAS NO.79794-75-5): 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26 
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes. 
S36: Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

 Loratadine (CAS NO.79794-75-5) is combined with pseudoephedrine, a decongestant; this makes it somewhat useful for colds as well as allergies, but adds potential side-effects of insomnia, nervousness and anxiety.
In the U.S. and UK, loratadine is the only drug of its class available over the counter (though it is no longer the only second generation antihistamine available in this manner).