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Name |
Lorazepam |
EINECS | 212-687-6 |
CAS No. | 846-49-1 | Density | 1.52 g/cm3 |
PSA | 61.69000 | LogP | 2.67490 |
Solubility | 54mg/L(temperature not stated) | Melting Point |
166-168 °C |
Formula | C15H10Cl2N2O2 | Boiling Point | 533.8 °C at 760 mmHg |
Molecular Weight | 321.163 | Flash Point | 276.7 °C |
Transport Information | UN 1230 3/PG 2 | Appearance | White crystalline solid |
Safety | 36/37-45-16 | Risk Codes | 63-39/23/24/25-23/24/25-11 |
Molecular Structure | Hazard Symbols | Xn,T,F | |
Synonyms |
Lorazep;Lorazin;Lorazon;Lorivan;Lorsilan;Merlit;NIC;NSC 289758;Novhepar;Novo-lorazem;Orfidal;Pro Dorm;Punktyl;Renaquil;Securit;Sedatival;Sedizepan;Silence;Somagerol;Tavor Expidet;Titus;Wintin;o-Chloroxazepam;2H-1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- (7CI,8CI);Anxira;Aplacassee;Bonatranquan;Demethyllormetazepam;Emotival;Laubeel; |
Article Data | 16 |
Molecular Structure of 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (CAS NO.846-49-1):
IUPAC Name: 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Canonical SMILES: C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
InChI: InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChIKey: DIWRORZWFLOCLC-UHFFFAOYSA-N
Molecular Weight: 321.1581 [g/mol]
Molecular Formula: C15H10Cl2N2O2
XLogP3: 2.4
H-Bond Donor: 2
H-Bond Acceptor: 3
EINECS: 212-687-6
storage temp.: −20 °C
Appearance: White Crystalline Solid
Index of Refraction: 1.693
Molar Refractivity: 81.03 cm3
Molar Volume: 211.1 cm3
Surface Tension: 56 dyne/cm
Density: 1.52 g/cm3
Flash Point: 276.7 °C
Enthalpy of Vaporization: 85.25 kJ/mol
Boiling Point: 533.8 °C at 760 mmHg
Vapour Pressure: 3.16E-12 mmHg at 25 °C
Melting Point: 166-168 °C
Water Solubility: 80 mg/L
Classification Code: Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Autonomic Agents; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; GABA Agents; GABA modulators; Gastrointestinal Agents; Human Data; Hypnotics and Sedatives; Neurotransmitter Agents; Peripheral Nervous System Agents; Psychotropic Drugs; Reproductive Effect; Tranquilizer [minor]; Tranquilizing Agents
7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (CAS NO.846-49-1) can be used as an anxiolytic and anticonvulsant.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 71ug/kg (0.071mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ATAXIA | Toxicology Letters. Vol. 2, Pg. 109, 1978. |
child | TDLo | oral | 1208ug/kg (1.208mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING | Pediatric Emergency Care. Vol. 11, Pg. 32, 1995. |
dog | LD50 | intramuscular | > 25mg/kg (25mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971. |
dog | LD50 | oral | > 2gm/kg (2000mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971. |
human | TDLo | oral | 21ug/kg (0.021mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING | Clinical Pharmacology and Therapeutics Vol. 39, Pg. 526, 1986. |
human | TDLo | oral | 28ug/kg (0.028mg/kg) | BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS | Journal of Clinical Psychiatry. Vol. 46, Pg. 137, 1985. |
mouse | LD50 | intramuscular | 70mg/kg (70mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971. |
mouse | LD50 | intraperitoneal | 1810mg/kg (1810mg/kg) | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 5, 1974. | |
mouse | LD50 | oral | 1850mg/kg (1850mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
mouse | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1(1), Pg. 5, 1974. | |
rat | LD50 | intramuscular | 59mg/kg (59mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971 |
rat | LD50 | intraperitoneal | 870mg/kg (870mg/kg) | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 10, Pg. 345, 1973. | |
rat | LD50 | oral | 4500mg/kg (4500mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
rat | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 1475, 1977. | |
women | TDLo | oral | 380ug/kg/19D- (0.38mg/kg) | BLOOD: APLASTIC ANEMIA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE | British Medical Journal. Vol. 296, Pg. 1332, 1988. |
Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: general anesthetic, hallucinations or distorted perceptions, loss of muscle control (ataxia), aplastic anemia, bone marrow changes. Human reproductive effects by ingestion: unspecified neonatal effects. An experimental teratogen. Other experimental reproductive effects. An anticonvulsant and tranquilizer. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Safety Information of 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (CAS NO.846-49-1):
Hazard Codes: Xn,T,F
Risk Statements: 63-39/23/24/25-23/24/25-11
R11:Highly flammable.
R39:Danger of very serious irreversible effects.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R63:Possible risk of harm to the unborn child.
Safety Statements: 36/37-45-16
S36/37:Wear suitable protective clothing and gloves.
S16:Keep away from sources of ignition.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1230 3/PG 2
WGK Germany: 3
RTECS: DF0350000
7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (CAS NO.846-49-1), its Synonyms are (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one ; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)- ; Almazine ; Anxiedin ; Anxira ; Anzepam ; Bonatranquan ; Bonton ; Delormetazepam ; Demethyllormetazepam ; Lorazepam ; Lorazepam Fabra ; Lorazepam Genericon ; o-Chlorooxazepam ; o-Chloroxazepam .