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Lorazepam

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Name

Lorazepam

EINECS 212-687-6
CAS No. 846-49-1 Density 1.52 g/cm3
PSA 61.69000 LogP 2.67490
Solubility 54mg/L(temperature not stated) Melting Point 166-168 °C
Formula C15H10Cl2N2O2 Boiling Point 533.8 °C at 760 mmHg
Molecular Weight 321.163 Flash Point 276.7 °C
Transport Information UN 1230 3/PG 2 Appearance White crystalline solid
Safety 36/37-45-16 Risk Codes 63-39/23/24/25-23/24/25-11
Molecular Structure Molecular Structure of 846-49-1 (Lorazepam) Hazard Symbols HarmfulXn,ToxicT,FlammableF
Synonyms

Lorazep;Lorazin;Lorazon;Lorivan;Lorsilan;Merlit;NIC;NSC 289758;Novhepar;Novo-lorazem;Orfidal;Pro Dorm;Punktyl;Renaquil;Securit;Sedatival;Sedizepan;Silence;Somagerol;Tavor Expidet;Titus;Wintin;o-Chloroxazepam;2H-1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- (7CI,8CI);Anxira;Aplacassee;Bonatranquan;Demethyllormetazepam;Emotival;Laubeel;

Article Data 16

Lorazepam Chemical Properties

Molecular Structure of 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (CAS NO.846-49-1):

IUPAC Name: 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Canonical SMILES: C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
InChI: InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChIKey: DIWRORZWFLOCLC-UHFFFAOYSA-N
Molecular Weight: 321.1581 [g/mol]
Molecular Formula: C15H10Cl2N2O2
XLogP3: 2.4
H-Bond Donor: 2
H-Bond Acceptor: 3 
EINECS: 212-687-6 
storage temp.: −20 °C
Appearance: White Crystalline Solid
Index of Refraction: 1.693
Molar Refractivity: 81.03 cm3
Molar Volume: 211.1 cm3
Surface Tension: 56 dyne/cm
Density: 1.52 g/cm3
Flash Point: 276.7 °C
Enthalpy of Vaporization: 85.25 kJ/mol
Boiling Point: 533.8 °C at 760 mmHg
Vapour Pressure: 3.16E-12 mmHg at 25 °C
Melting Point: 166-168 °C
Water Solubility: 80 mg/L
Classification Code: Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Autonomic Agents; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; GABA Agents; GABA modulators; Gastrointestinal Agents; Human Data; Hypnotics and Sedatives; Neurotransmitter Agents; Peripheral Nervous System Agents; Psychotropic Drugs; Reproductive Effect; Tranquilizer [minor]; Tranquilizing Agents

Lorazepam Uses

 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (CAS NO.846-49-1) can be used as an anxiolytic and anticonvulsant.

Lorazepam Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 71ug/kg (0.071mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: ATAXIA
Toxicology Letters. Vol. 2, Pg. 109, 1978.
child TDLo oral 1208ug/kg (1.208mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
Pediatric Emergency Care. Vol. 11, Pg. 32, 1995.
dog LD50 intramuscular > 25mg/kg (25mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971.
dog LD50 oral > 2gm/kg (2000mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: NAUSEA OR VOMITING
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971.
human TDLo oral 21ug/kg (0.021mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING
Clinical Pharmacology and Therapeutics Vol. 39, Pg. 526, 1986.
human TDLo oral 28ug/kg (0.028mg/kg) BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS Journal of Clinical Psychiatry. Vol. 46, Pg. 137, 1985.
mouse LD50 intramuscular 70mg/kg (70mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971.
mouse LD50 intraperitoneal 1810mg/kg (1810mg/kg)   Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 5, 1974.
mouse LD50 oral 1850mg/kg (1850mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1(1), Pg. 5, 1974.
rat LD50 intramuscular 59mg/kg (59mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971
rat LD50 intraperitoneal 870mg/kg (870mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 10, Pg. 345, 1973.
rat LD50 oral 4500mg/kg (4500mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 1475, 1977.
women TDLo oral 380ug/kg/19D- (0.38mg/kg) BLOOD: APLASTIC ANEMIA

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
British Medical Journal. Vol. 296, Pg. 1332, 1988.

Lorazepam Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: general anesthetic, hallucinations or distorted perceptions, loss of muscle control (ataxia), aplastic anemia, bone marrow changes. Human reproductive effects by ingestion: unspecified neonatal effects. An experimental teratogen. Other experimental reproductive effects. An anticonvulsant and tranquilizer. When heated to decomposition it emits very toxic fumes of Cl and NOx
Safety Information of 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (CAS NO.846-49-1):
Hazard Codes: HarmfulXn,ToxicT,FlammableF
Risk Statements: 63-39/23/24/25-23/24/25-11 
R11:Highly flammable. 
R39:Danger of very serious irreversible effects. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R63:Possible risk of harm to the unborn child.
Safety Statements: 36/37-45-16 
S36/37:Wear suitable protective clothing and gloves. 
S16:Keep away from sources of ignition. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1230 3/PG 2
WGK Germany: 3
RTECS: DF0350000

Lorazepam Specification

 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (CAS NO.846-49-1), its Synonyms are (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one ; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)- ; Almazine ; Anxiedin ; Anxira ; Anzepam ; Bonatranquan ; Bonton ; Delormetazepam ; Demethyllormetazepam ; Lorazepam ; Lorazepam Fabra ; Lorazepam Genericon ; o-Chlorooxazepam ; o-Chloroxazepam .