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Basic information

  • Name:

  • Losartan potassium

  • CAS No.:

  • 124750-99-8

  • Formula:
  • C22H22ClKN6OK
  • Synonyms:
  • Lotim;L-158086;Ocsaar;Losacor;Tenopres;Lortaan;Losaprex;Hyzaar;Niten;DuP 753;Losartan monopotassium salt;MK 954;Lorzaan;Cozaar;Llosartan;Losartanpotassium;Lorzaar;1H-Imidazole-5-methanol,2-butyl-4-chloro- 1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]- methyl]-,monopotassium salt;2-Butyl-4-chloro-1-(2-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5-methanol potassium;MK-0954;Losacar;MK 0954;potassium [2-butyl-5-chloro-3-[[4-[2-(2,3,4-triaza-1-azanidacyclopenta-2,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;Cozaar (TN);

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Chemistry

Structure of Losartan potassium (CAS NO.124750-99-8):

IUPAC Name: Potassium [2-butyl-5-chloro-3-[[4-[2-(2,3,4-triaza-5-azanidacyclopenta-1,3-dien-1-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Molecular Formula: C22H22ClKN6O
Molar mass: 461.00098 g/mol
Flash Point: 366.3 °C
Enthalpy of Vaporization: 105.1 kJ/mol
Boiling Point: 682 °C at 760 mmHg
Vapour Pressure: 1.55E-19 mmHg at 25 °C
H-Bond Donor: 1
H-Bond Acceptor: 6
Rotatable Bond Count: 8
Tautomer Count: 2
Exact Mass: 460.118069
MonoIsotopic Mass: 460.118069
Topological Polar Surface Area: 77.7
Heavy Atom Count: 31 
Canonical SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]
InChI: InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
InChIKey: OXCMYAYHXIHQOA-UHFFFAOYSA-N
Product Categories: Hypertension; Intermediates & Fine Chemicals; Pharmaceuticals; Losartan

Uses

 Losartan potassium (CAS NO.124750-99-8) can be used as a nonpeptide angiotensin II AT1-receptor antagonist.

Toxicity Data With Reference

dog LD oral > 320mg/kg (320mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
man TDLo oral 10mg/kg/2W-I (10mg/kg) BLOOD: HEMORRHAGE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Archives of Internal Medicine. Vol. 158, Pg. 191, 1998.
mouse LDLo intraperitoneal 400mg/kg (400mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
mouse LDLo oral 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
rat LDLo intraperitoneal 200mg/kg (200mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
rat LDLo oral 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
women TDLo oral 1mg/kg/1D-I (1mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Archives of Internal Medicine. Vol. 158, Pg. 2063, 1998.

Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RTECS: NI6755100

Specification

 Losartan potassium (CAS NO.124750-99-8) is also named as 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, monopotassium salt ; 2-Butyl-4-chloro-1-(2'-(tetrazol-5-yl)biphenyl-4-ylmethyl)-
1H-imidazole-5-methanol potassium ; 2-Butyl-4-chloro-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)imidazole-5-methanol, monopotassium salt ; Cozaar ; Du Pont 753 ; DuP 753 ; HSDB 7043 ; L-158086 ; Lifezar ; Lortaan ; Lorzaan ; Lorzaar ; Losacar ; Losacor ; Losaprex ; Losartan ; Lotim ; MK 0954 ; MK-0954 ; Neo Lotan ; Niten ; Ocsaar ; Tenopres ; UNII-3ST302B24A . Losartan potassium (CAS NO.124750-99-8) is white to off-white crystalline powder.

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