Loxoprofen (80382-23-6),Loxoprofen (80382-23-6) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Loxoprofen sodium
CAS No.:
80382-23-6
Molecular Structure:
Formula:
C₁₅H₂₁NaO₅
Molecular Weight:
304.35
Synonyms:
Benzeneaceticacid, a-methyl-4-[(2-oxocyclopentyl)methyl]-,sodium salt (9CI);CS 600;CS 600 (antiinflammatory);Loxonin;Loxoprofensodium;Sodium 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionate;Sodiumloxoprofen;
Boiling Point:
417.9 °C at 760 mmHg
Flash Point:
220.7 °C

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Chemistry

Molecular Structure:

Molecular Formula: C₁₅H₂₁NaO₅
Molecular Weight: 304.314
IUPAC Name: Sodium 2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate dihydrate
Synonyms of Loxoprofen (CAS NO.80382-23-6): CS-600 ; Loxoprofen sodium dihydrate ; Sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate dihydrate ; alpha-Methyl-4-((2-oxocyclopentyl)methyl)benzeneacetate sodium salt dihydrate ; Benzeneacetic acid, alpha-methyl-4-((2-oxocyclopentyl)methyl)-, sodium salt, dihydrate
CAS NO: 80382-23-6
Classification Code: Drug / Therapeutic Agent ; Human Data ; Reproductive Effect
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 4
Polar Surface Area: 54.37 Å²
Flash Point: 220.7 °C
Enthalpy of Vaporization: 70.78 kJ/mol
Boiling Point: 417.9 °C at 760 mmHg
Vapour Pressure: 9.92E-08 mmHg at 25°C

Uses

Loxoprofen (CAS NO.80382-23-6) is used for chronic wet arthritis, deformation arthritis, lumbago, periarthritis of shoulder, syndrome of neck and shoulder.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	LDLo	oral	857ug/kg (0.857mg/kg)	LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 333, 1993.
mouse	LD50	intraperitoneal	1020mg/kg (1020mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
mouse	LD50	intravenous	740mg/kg (740mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
mouse	LD50	oral	3030mg/kg (3030mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
mouse	LD50	subcutaneous	1070mg/kg (1070mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
rat	LD50	intraperitoneal	245mg/kg (245mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
rat	LD50	intravenous	155mg/kg (155mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
rat	LD50	oral	145mg/kg (145mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
rat	LD50	subcutaneous	285mg/kg (285mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.

Consensus Reports

Loxoprofen (CAS NO.80382-23-6) Market Research Report 2009