Luteolin (491-70-3),Luteolin (491-70-3) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Luteolin
CAS No.:
491-70-3
Molecular Structure:
Formula:
C₁₅H₁₀O₆
Molecular Weight:
286.24
Synonyms:
4H-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-;Cyanidenon 1470;Prestwick_122;Flacitran;4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy- (9CI);2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone;2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one;4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-;3,4,5,7-Tetrahydroxyflavone;5,7,3,4-Tetrahydroxyflavone;C.I. Natural Yellow 2;2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one;C.I. 75590;Luteolol;Digitoflavone;3',4',5,7-Tetrahydroxyflavone;
EINECS:
207-741-0
Density:
1.654 g/cm³
Melting Point:
~330 °C(lit.)
Boiling Point:
616.1 °C at 760 mmHg
Flash Point:
239.5 °C
Appearance:
yellow crystalline powder
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety Description:
26-36-36/37/39 Details
particular:
particular

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Chemistry

Molecular Structure of Luteolin (CAS NO.491-70-3):

IUPAC Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
Empirical Formula: C₁₅H₁₀O₆
Molecular Weight: 286.2363
H bond acceptors: 6
H bond donors: 4
Freely Rotating Bonds: 5
Polar Surface Area: 63.22Å²
Index of Refraction: 1.767
Molar Refractivity: 71.73 cm³
Molar Volume: 172.9 cm³
Surface Tension: 92.5 dyne/cm
Density: 1.654 g/cm³
Flash Point: 239.5 °C
Enthalpy of Vaporization: 94.73 kJ/mol
Boiling Point: 616.1 °C at 760 mmHg
Vapour Pressure: 9.03E-16 mmHg at 25°C
Melting point: 330 ^oC
Storage temp: 2-8^oC
EINECS: 207-741-0
Product Categories: Tetra-substituted Flavones; Natural Plant Extract; Inhibitors; Tyrosine Kinase Inhibitors; Cytokine signaling
InChI
InChI=1/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
Smiles
c12c(c(cc(o1)c1cc(c(O)cc1)O)=O)c(cc(c2)O)O

Uses

Luteolin (CAS NO.491-70-3) is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an agent in the prevention of inflammation, a promoter of carbohydrate metabolism and an immune system modulator. Multiple research experiments describe luteolin as a biochemical agent that can dramatically reduce inflammation and the symptoms of septic shock.These characteristics of luteolin are also believed to play an important part in the prevention of cancer.

Toxicity Data With Reference

1.	mnt-hmn-lym 10 mg/L	MUREAV Mutation Research. 246 (1991),205.
2.	sce-hmn-lym 10 mg/L	MUREAV Mutation Research. 246 (1991),205.
3.	sln-hmn-lym 20 mg/L	MUREAV Mutation Research. 246 (1991),205.
4.	ipr-mus LD50:180 mg/kg	YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. 16 (2)(1981),11.

Safety Profile

A poison by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
RTECS: LK9275210

Specification

Luteolin , with CAS number of 491-70-3, can be called 3',4',5,7-Tetrahydroxyflavone ; 5,7,3',4'-Tetrahydroxyflavone ; Digitoflavone ; Luteoline ; Salifazide . Luteolin (CAS NO.491-70-3) is often found in leaves, but it is also seen in celery, thyme, dandelion, rinds, barks, clover blossom and ragweed pollen. Luteolin has also been isolated from Salvia tomentosa. Dietary sources include celery, green pepper, thyme, perilla and camomile tea.