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Name	MAEM	EINECS	279-540-6
CAS No.	84994-24-1	Density	1.63g/cm³
PSA	171.19000	LogP	3.67310
Solubility	N/A	Melting Point	N/A
Formula	C13H10 N4 O3 S2	Boiling Point	563.2°C at 760 mmHg
Molecular Weight	350.44	Flash Point	294.4°C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	Xi:Irritant;
Molecular Structure		Hazard Symbols	R36/37/38:;
Synonyms	4-Thiazoleaceticacid, 2-amino-a-(methoxyimino)-,2-benzothiazolyl ester, (Z)-;(Z)-2-[Methoxyimino]-2-(2-aminothiazol-4-yl)acetic acid;(Z)-2-[Methoxyimino]-2-(2-aminothiazol-4-yl)acetic acid 2-benzothiazole ester

MAEM Synthetic route

: 84994-24-1
2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester

: 7-amino-3-[2-(5-methyl-2H-tetrazolyl)methyl]cephalosporanic acid

: 82547-58-8
cefteram

Conditions

Conditions	Yield
With sodium metabisulfite; triethylamine In methanol; dichloromethane at 0℃; for 3h;	89.1%

: 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid

: 7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid

: 84994-24-1
2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester

A: 104146-53-4
7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt

B: 104146-16-9
7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt

Conditions

Conditions	Yield
Stage #1: 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; 7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; 2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester With triethylamine In water; acetone at 0 - 15℃; for 3 - 4h; Stage #2: With sodium 2-ethylhexanoic acid In water; acetone at 20 - 25℃; for 1h; Product distribution / selectivity;

Yield

Stage #1: 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; 7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; 2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester With triethylamine In water; acetone at 0 - 15℃; for 3 - 4h;
Stage #2: With sodium 2-ethylhexanoic acid In water; acetone at 20 - 25℃; for 1h; Product distribution / selectivity;

MAEM Chemical Properties

Product Name: Maem
Synonyms : Benzothiazol-2-yl (Z)-2-methoxyimino-2-(2-aminothiazole-4-yl)thioacetate
Molecular Structure of Maem (CAS NO. 84994-24-1) :
Molecular Formula of Maem (CAS NO. 84994-24-1) : C₁₃H₁₀N₄O₂S₃
Molecular Weight of Maem (CAS NO. 84994-24-1) : 350.44
CAS NO: 84994-24-1
Product Categories: Amines;Cefotaxime;Ceftriaxone
Mol File: 84994-24-1.mol
Appearance: Maem (CAS NO. 84994-24-1) is white or light yellow crystalline powder.

MAEM Uses

Maem (CAS NO. 84994-24-1) is intermediates of Cephalosporins antibiotics drugs , and raw materials in the production of ceftriaxone, cefotaxime sodium and other drug.

MAEM Production

Maem (CAS NO. 84994-24-1) can be obtained ,with AT, M as raw materials and cyclohexyl carbodiimide and pyridine as the catalyst.

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