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Metformin hydrochloride (1115-70-4)

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Chemistry

Molecular Structure of Metformin hydrochloride (CAS NO.1115-70-4):

IUPAC Name: 3-(Diaminomethylidene)-1,1-dimethylguanidine hydrochloride
Molecular Formula: C4H11N5.HCl
Molecular Weight: 165.62
H bond acceptors: 5
H bond donors: 5
Freely Rotating Bonds: 1
Polar Surface Area: 34.44Å2
Merck: 13,5963
Flash Point: 89.3 °C
Enthalpy of Vaporization: 46.06 kJ/mol
Boiling Point: 224.1 °C at 760 mmHg
Vapour Pressure: 0.0929 mmHg at 25°C
Melting point: 223-226 ºC
Appearance: Crystalline Solid
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; API's; Miscellaneous Compounds
InChI
InChI=1/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
Smiles
C(NC(N)=N)(N(C)C)=N.Cl

Production

  Metformin hydrochloride (CAS NO.1115-70-4) is derived by Dimethylamine salt reacting with Dicyandiamide.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intramuscular 200mg/kg (200mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 474, 1960.
guinea pig LD50 intraperitoneal 200mg/kg (200mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 474, 1960.
guinea pig LD50 oral 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
guinea pig LD50 subcutaneous 150mg/kg (150mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
mouse LD50 intraperitoneal 420mg/kg (420mg/kg)   Drugs in Japan Vol. 6, Pg. 841, 1982.
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04012,
mouse LD50 oral 1450mg/kg (1450mg/kg)   Drugs in Japan Vol. 6, Pg. 841, 1982.
mouse LD50 subcutaneous 225mg/kg (225mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
rabbit LD50 oral 350mg/kg (350mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
rabbit LD50 subcutaneous 150mg/kg (150mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
rat LD50 intraperitoneal 500mg/kg (500mg/kg)   French Demande Patent Document. Vol. #2220256,
rat LD50 oral 1gm/kg (1000mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 934, 1989.
rat LD50 subcutaneous 300mg/kg (300mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 934, 1989.

Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 22-36/38
R22:Harmful if swallowed. 
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DU1800000

Specification

  Metformin hydrochloride , with CAS number of 1115-70-4, can be called 1,1-Dimethyl-biguanidhydrochloride ; Diabefagos ; Diformin ; Dimethylbiguanidehydrochloride ; Dimethyldiguanidinehydrochloride . Metformin hydrochloride (CAS NO.1115-70-4) is an oral hypoglycemic agent.

Basic information

  • Product Name:

    Metformin hydrochloride

  • CAS No:1115-70-4
  • Formula:C4H12ClN5
  • Synonyms:Biguanide,1,1-dimethyl-, hydrochloride (6CI);Biguanide, 1,1-dimethyl-, monohydrochloride(8CI);Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride (9CI);1,1-Dimethylbiguanide hydrochloride;Apo-Metformin;Apophage;Benofomin;Brot;Dabex;Denkaform;Dextin;Diabefagos;Diabetmin;Diabetosan;Diabex;Diaformin;Dialon;Diformin;Diformin Retard;Dimefor;Fornidd;Geamet;Glifage;Glucaminol;Glucofago;Glucoform;Glucomet;Glucomin;Glucomine;Gluconil;Glucophage;Glucophage 850;Glucophage Forte;Glucophage Retard;Glucophage SR;Glucophage XR;Glucophage-Mite;Gludepatic;Glufor;Gluformin;Glumeformin;Glumetza;Glumin;Glupermin;Glyceriphage;Glyciphage;Glycon;Glyformin;LA6023;Meguan;Metforal;Metomin;Miformin;N,N-Dimethylbiguanide hydrochloride;N,N-Dimethylbiguanidinium chloride;N1,N1-Dimethylbiguanide hydrochloride;Orabet;Siamformet;Walaphage;Metformin Hcl;
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