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| Name |
METHYLCHLORTETRACYCLINE |
EINECS | N/A |
| CAS No. | 127-33-3 | Density | 1.75g/cm3 |
| PSA | 181.62000 | LogP | 0.96520 |
| Solubility | 1.4g/L(25 oC) | Melting Point |
176°C (rough estimate) |
| Formula | C21H21 Cl N2 O8 | Boiling Point | 684.5°Cat760mmHg |
| Molecular Weight | 464.859 | Flash Point | 367.8°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous and intraperitoneal routes. Human systemic effects by ingestion: diabetes insipidus, urine volume increase, other changes in urine composition, dermatitis, changes in the nails, allergic rhinitis, serum sickness, effects on cyclic nucleotides. Human reproductive effects by an unspecified route: postnatal measures or effects on newborn. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-(8CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,[4S-(4a,4aa,5aa,6b,12aa)]-; 6-Demethyl-7-chlorotetracycline;6-Demethyl-7-chlortetracycline; 6-Demethylchlorotetracycline;6-Demethylchlortetracycline;7-Chloro-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide;7-Chloro-6-demethyltetracycline; Bioterciclin; Chlortetracycline, 6-demethyl-;DMCT; DMCT (antibiotic); Deganol; Demeclocycline; Demeclor;Demethylchlorotetracycline; Demethylchlortetracyclin;Demethylchlortetracycline; Demetraclin; Diuciclin; Elkamicina; Ledermycin;Mexocine; Novotriclina; Perciclina; Periciclina; RP 10192; Sumaclina;Tri-demethylchlortetracycline |
METHYLCHLORTETRACYCLINE Chemical Properties
Product Name: Methylchlortetracycline (CAS NO.127-33-3)
Molecular Formula: C21H21ClN2O8
Molecular Weight: 464.89g/mol
Mol File: 127-33-3.mol
Einecs: 204-834-8
Boiling point: 787.1 °C at 760 mmHg
Flash Point: 429.8 °C
Density: 1.75g/cm3
Surface Tension: 107.9 dyne/cm
Enthalpy of Vaporization: 120.1 kJ/mol
Vapour Pressure: 4.19E-26 mmHg at 25°C
XLogP3: -0.6
H-Bond Donor: 6
H-Bond Acceptor: 10
METHYLCHLORTETRACYCLINE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 10mg/kg (10mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): NAILS: OTHER | British Medical Journal. Vol. 2, Pg. 96, 1977. |
| human | TDLo | oral | 68mg/kg/8D (68mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | Current Therapeutic Research, Clinical & Experimental. Vol. 15, Pg. 734, 1973. |
| human | TDLo | oral | 420mg/kg/6W (420mg/kg) | ENDOCRINE: DIABETES INSIPIDUS (NEPHROGENIC OR CNS) | Annals of Internal Medicine. Vol. 79, Pg. 679, 1973. |
| mouse | LD50 | intraperitoneal | 454mg/kg (454mg/kg) | Drugs in Japan Vol. 6, Pg. 497, 1982. | |
| mouse | LD50 | intravenous | 79mg/kg (79mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 281, 1970. | |
| mouse | LDLo | oral | 4gm/kg (4000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 350, 1960. | |
| mouse | LDLo | subcutaneous | 2500mg/kg (2500mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 350, 1960. | |
| rat | LD50 | intraperitoneal | 358mg/kg (358mg/kg) | Drugs in Japan Vol. 6, Pg. 497, 1982. | |
| rat | LD50 | intravenous | 146mg/kg (146mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
| rat | LD50 | oral | > 6750mg/kg (6750mg/kg) | Drugs in Japan Vol. 6, Pg. 497, 1982. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. 6, Pg. 497, 1982. |
METHYLCHLORTETRACYCLINE Safety Profile
Poison by intravenous and intraperitoneal routes. Human systemic effects by ingestion: diabetes insipidus, urine volume increase, other changes in urine composition, dermatitis, changes in the nails, allergic rhinitis, serum sickness, effects on cyclic nucleotides. Human reproductive effects by an unspecified route: postnatal measures or effects on newborn. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
METHYLCHLORTETRACYCLINE Specification
Methylchlortetracycline ,its CAS NO. is 127-33-3,the synonyms is Demethylchlortetracycline ; 7-Chloro-6-demethyltetracycline ; Demethyichlortetracycline ; Methylchlorotetracycline ; Demethylchlorotetracycline ; 10192 Rp ; Bioterciclin ; Deganol .
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