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Mafenide acetate

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Name Mafenide acetate EINECS 235-855-0
CAS No. 13009-99-9 Density
Solubility Melting Point 151-152 °C
Formula C7H10N2O2S.C2H4O2 Boiling Point 382 °C at 760 mmHg
Molecular Weight 246.31 Flash Point 184.8 °C
Transport Information Appearance Crystalline solid
Safety Risk Codes
Molecular Structure Molecular Structure of 13009-99-9 (Mafenide acetate) Hazard Symbols
Synonyms

Winthrocine;Mafenide acetate (JAN/USP);p-Toluenesulfonamide, alpha-amino-, monoacetate;Sulfamylon (TN);alpha-Aminotoluene-4-sulphonamide monoacetate;α-aminotoluene-4-sulphonamide monoacetate;Mafenide acetate (USP31);Mafenide acetate [USAN:JAN];alpha-Amino-p-toluenesulfonamide monoacetate;Maphenide acetate;Benzenesulfonamide, 4-(aminomethyl)-, monoacetate;p-Aminomethylbenzenesulfonamide acetate;4-(Aminomethyl)benzenesulfonamide monoacetate;acetic acid; 4-(aminomethyl)benzenesulfonamide;Sulfamilon;

 

Chemistry

Molecular Structure of Mafenide acetate (CAS NO.13009-99-9):

IUPAC Name: acetic acid; 4-(aminomethyl)benzenesulfonamide 
Empirical Formula: C9H14N2O4S
Molecular Weight: 246.2835
ACD/LogP: -0.80
of Rule of 5 Violations: 0
ACD/LogD (pH 5.5): -3.61
ACD/LogD (pH 7.4): -2.03
ACD/BCF (pH 5.5): 1
ACD/BCF (pH 7.4): 1
ACD/KOC (pH 5.5): 1
ACD/KOC (pH 7.4): 1
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 3
Polar Surface Area: 49 Å2
Flash Point: 184.8 °C
Enthalpy of Vaporization: 63.04 kJ/mol
Boiling Point: 382 °C at 760 mmHg
Vapour Pressure: 4.86E-06 mmHg at 25°C
Melting point: 151-152°C
EINECS: 235-855-0
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 5425mg/kg (5425mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mammal (species unspecified) LC inhalation > 320mg/m3 (320mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse LD50 intraperitoneal 2322mg/kg (2322mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse LD50 intravenous 1580mg/kg (1580mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Life Sciences. Vol. 5, Pg. 2279, 1966.
mouse LD50 oral 10183mg/kg (10183mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Yakkyoku. Pharmacy. Vol. 30, Pg. 1517, 1979.
rat LD50 intraperitoneal 1560mg/kg (1560mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 884, 1979.
rat LD50 intravenous 1730mg/kg (1730mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 884, 1979.
rat LD50 oral 9212mg/kg (9212mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Yakkyoku. Pharmacy. Vol. 30, Pg. 1517, 1979.

Safety Profile

Moderately toxic by intravenous and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Used as an antibacterial agent. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Safety information of Mafenide acetate (CAS NO.13009-99-9):
WGK Germany: 3

Specification

  Mafenide acetate , with CAS number of 13009-99-9, can be called α-aminotoluene-4-sulphonamide monoacetate ; alpha-Aminotoluene-4-sulphonamide monoacetate ; p-Toluenesulfonamide, alpha-amino-, monoacetate ; acetic acid; 4-(aminomethyl)benzenesulfonamide ; Benzenesulfonamide, 4-(aminomethyl)-, monoacetate . Mafenide acetate (CAS NO.13009-99-9) is used asa sulfonamide, partial for Pseudomonas aeruginosa or other bacterial infections, the treatment of burn wounds.

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