Matrine (519-02-8),Matrine (519-02-8) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aS,13aR,13bR,13cS)-
Superlist Name:
Matrine
CAS No.:
519-02-8
Molecular Structure:
Formula:
C₁₅H₂₄N₂O
Molecular Weight:
248.37
Synonyms:
Matridin-15-one;Matridin-15-one (9CI);1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]- naphthyridin-10-one,dodecahydro-,(7aS,- 13aR,13bR,13cS)-;Matrene, (+)-;5-24-02-00301 (Beilstein Handbook Reference);(+)-Matrine;Shrubby Sophora Extract;α-Matrine;Vegard;
Density:
1.16 g/cm³
Melting Point:
77 °C
Boiling Point:
396.7 °C at 760 mmHg
Flash Point:
172.7 °C
Hazard Symbols:
Xn
Risk Codes:
20/21/22-37/38-41-48
Safety Description:
22-26-36/37/39-45 Details
particular:
particular

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Chemistry

Molecule structure of Matrine (CAS NO.519-02-8):

Molecular Formula: C₁₅H₂₄N₂O
Molecular Weight: 248.363860 g/mol
Density: 1.16 g/cm³
Melting Point: 77 °C
Boiling Point: 396.7 °C at 760 mmHg
Flash Point: 172.7 °C
Index of Refraction: 1.581
Molar Refractivity: 71.12 cm³
Molar Volume: 213.3 cm³
Surface Tension: 48.3 dyne/cm
Enthalpy of Vaporization: 64.71 kJ/mol
Vapour Pressure: 1.67E-06 mmHg at 25 °C
XLogP3-AA: 1.6
H-Bond Acceptor: 2
Tautomer Count: 2
Exact Mass: 248.188863
MonoIsotopic Mass: 248.188863
Topological Polar Surface Area: 23.6
Heavy Atom Count: 18
Canonical SMILES: C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1
InChI: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2
InChIKey: ZSBXGIUJOOQZMP-UHFFFAOYSA-N
EINECS: 209-012-2
Product Categories: Miscellaneous Natural Products; Natural Plant Extract

Uses

Matrine (CAS NO.519-02-8) is an anti-inflammatory drug for the treatment of chronic cervicitis, dysentery, enteritis and other diseases antibacterial anti-inflammatory drugs for chronic cervicitis, dysentery, enteritis and so on.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intramuscular	74150ug/kg (74.15mg/kg)	Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 201, 1992.
mouse	LD50	intraperitoneal	150mg/kg (150mg/kg)	Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 18, Pg. 214, 1987.
mouse	LD50	intravenous	64850ug/kg (64.85mg/kg)	Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 201, 1992.
rat	LD50	intraperitoneal	125mg/kg (125mg/kg)	Chemical and Pharmaceutical Bulletin. Vol. 18, Pg. 2555, 1970.

Safety Profile

Hazard Codes: Xn
Risk Statements: 20/21/22-37/38-41-48
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
37/38: Irritating to respiratory system and skin
41: Risk of serious damage to eyes
48: Danger of serious damage to health by prolonged exposure
Safety Statements: 22-26-36/37/39-45
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Specification

Matrine (CAS NO.519-02-8) is also named as (+)-Matrine ; 5-24-02-00301 (Beilstein Handbook Reference) ; BRN 0085851 ; Matrene, (+)- ; NSC 146051 ; Matridin-15-one (9CI) .