- Meclizine dihydrochloride
- Meclizine hydrochloride
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Cas Database |
| Name |
Meclizine dihydrochloride |
EINECS | 214-164-8 |
| CAS No. | 1104-22-9 | Density | 1.159g/cm3 |
| PSA | 6.48000 | LogP | 7.03540 |
| Solubility | N/A | Melting Point |
210.0 to 214.0 °C |
| Formula | C25H29Cl3N2 | Boiling Point | 495.3 °C at 760 mmHg |
| Molecular Weight | 463.878 | Flash Point | 253.3 °C |
| Transport Information | N/A | Appearance | white,slightly yellowish,crystalline powder |
| Safety | 22-36 | Risk Codes | 22-63 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Piperazine,1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-,dihydrochloride (6CI,8CI);Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride(9CI);1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride;Ancolandihydrochloride;Bonamine;Diadril;Meclizine dihydrochloride;Meclizinehydrochloride;Meclozine dihydrochloride;Meclozine hydrochloride;NSC 28728;Navidoxine;Parachloramine dihydrochloride;Postafen;Postafene dihydrochloride; |
Article Data | 1 |
Meclizine dihydrochloride Chemical Properties
IUPAC: 1-[(4-Chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride
The molecular structure of Meclozine dihydrochloride (CAS NO.1104-22-9):
Molecular Formula: C25H29Cl3N2
Molecular Weight: 463.87
EINECS: 214-164-8
LogP: ACD/LogP: 4.99
ACD/LogD (pH 5.5): 3.86
ACD/LogD (pH 7.4): 4.93
ACD/BCF (pH 5.5): 270.77
ACD/BCF (pH 7.4): 3158.05
ACD/KOC (pH 5.5): 915.03
ACD/KOC (pH 7.4): 10672.26
Covalently-Bonded Unit Count: 3
Flash Point: 253.3°C
Storage temp.: 2-8 °C
Enthalpy of Vaporization: 76.28 kJ/mol
Boiling Point: 495.3°C at 760 mmHg
Vapour Pressure: 6E-10 mmHg at 25 °C
The appearance of Meclozine dihydrochloride (CAS NO.1104-22-9): white,slightly yellowish,crystalline powder
Canonical SMILES: CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl
InChI: InChI=1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H
InChIKey: VCTHNOIYJIXQLV-UHFFFAOYSA-N
Meclizine dihydrochloride Uses
Meclozine dihydrochloride (CAS NO.1104-22-9) is used as antiemetic, histamine H1 antagonist and anti-allergic agent.
Meclizine dihydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 625mg/kg (625mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954. |
| mouse | LD50 | oral | 1600mg/kg (1600mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 67, 1969. |
Meclizine dihydrochloride Consensus Reports
Reported in EPA TSCA Inventory.
Meclizine dihydrochloride Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Hazard Codes: 
Xn
Risk Statements: 22-63
R22:Harmful if swallowed.
R63:Possible risk of harm to the unborn child.
Safety Statements: 22-36
S22:Do not breathe dust.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: TL2005000
Meclizine dihydrochloride Specification
Meclozine dihydrochloride (CAS NO.1104-22-9) is also called for 1-p-Chlorbenzhydryl-m-methylbenzylpiperazine dihydrochloride ; Ancolan dihydrochloride ; Antivert ; Bonamine ; Diadril ; Duremesin ; EINECS 214-164-8 ; Meclizine HCl ; Meclizine dihydrochloride ; NSC 28728 ; Parachloramine dihydrochloride ; Postafen ; Postafene dihydrochloride ; Taizer ; UNII-L997QXC9J1 ; V-Cline ; Vertizine and so on. Its classification code are Drug / Therapeutic Agent and Reproductive Effect.
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