Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Megestrol acetate

Related Products

Hot Products

Name

Megestrol acetate

EINECS 209-864-5
CAS No. 595-33-5 Density 1.15 g/cm3
PSA 60.44000 LogP 4.57530
Solubility N/A Melting Point 214 °C
Formula C24H32O4 Boiling Point 507.1 °C at 760 mmHg
Molecular Weight 384.516 Flash Point 218.5 °C
Transport Information N/A Appearance Crystalline Solid
Safety 22-24/25 Risk Codes 40-48
Molecular Structure Molecular Structure of 595-33-5 (Megestrol acetate) Hazard Symbols HarmfulXn
Synonyms

Megace ES;Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-;Ovarid;Megace;Ovaban (Veterinary);Megeron;6-Methyl-delta4,6-pregnadien-17alpha-ol-3,20-dione acetate;6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone;Megace (TN);SC 10363;Megestryl acetate;Pregna-4,6-diene-3, 20-dione, 17-hydroxy-6-methyl-, acetate;Pallace;Ovaban;S4;6-Methyl-17-alpha-hydroxy-delta(sup 6)-progesterone acetate;SC-10363;SC10363;Niagestin;Progesterone, 6-dehydro-17-hydroxy-6-methyl-, acetate;6-Methyl-delta(sup 4,6)-pregnadien-17-alpha-ol-3,20-dione acetate;Megestrol acetate [USAN];17alpha-Acetoxy-6-dehydro-6-methylprogesterone;Megestrol acetate (USAN);Megestat;6-Dehydro-6-methyl-17.alpha.-acetoxyprogesterone;17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate;Megestrol acetole [Progestins];6-MethleneProgesterone Acetate;Pregna-4,6-diene-3, 20-dione, 17- (acetyloxy)-6-methyl-;BDH 1298;

Article Data 30

Megestrol acetate Synthetic route

74-83-9

methyl bromide

C27H38O7

595-33-5

Megestrol acetate

Conditions
ConditionsYield
Stage #1: methyl bromide; C27H38O7 With magnesium In tetrahydrofuran at 30 - 55℃; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 60 - 65℃;
69.8%
4382-76-7

methoxymethyl acetate

595-33-5

Megestrol acetate

Conditions
ConditionsYield
With sodium acetate; trichlorophosphate In chloroform at 70℃; for 0.166667h;51%
With sodium acetate; trichlorophosphate In chloroform
71-58-9

Medroxyprogesterone acetate

595-33-5

Megestrol acetate

Conditions
ConditionsYield
With chloranil
With 2-methyl-propan-1-ol; chloranil Heating;
With chloranil
Multi-step reaction with 2 steps
1: TsOH / dioxane
2: (tBuO)2CrO2, Ac2O / CCl4
View Scheme
71-58-9

Medroxyprogesterone acetate

118-75-2

chloranil

64-19-7

acetic acid

141-78-6

ethyl acetate

595-33-5

Megestrol acetate

71-58-9

Medroxyprogesterone acetate

118-75-2

chloranil

75-65-0

tert-butyl alcohol

595-33-5

Megestrol acetate

1104-99-0

3-Methoxy-17α-acetoxy-6-methyl-pregnadien-(3,5)-on-(20)

595-33-5

Megestrol acetate

Conditions
ConditionsYield
With acetic anhydride In tetrachloromethane
2381-48-8

6-methylpregn-5-ene-3β,17α-diol-20-one 17-acetate

595-33-5

Megestrol acetate

Conditions
ConditionsYield
With aluminum tri-tert-butoxide; p-benzoquinone
1863-39-4

3β-acetoxy-17α-hydroxy-5-pregnen-20-one

595-33-5

Megestrol acetate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: benzene; toluene-4-sulfonic acid
2: peroxybenzoic acid; chloroform
3: benzene; diethyl ether
4: aqueous methanol.H2SO4
5: CrO3; pyridine
6: aqueous HCl
7: acetic acid; toluene-4-sulfonic acid
8: tetrachloro-<1,4>benzoquinone
View Scheme
520-85-4

Medroxyprogesterone

595-33-5

Megestrol acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; toluene-4-sulfonic acid
2: tetrachloro-<1,4>benzoquinone
View Scheme
113665-92-2

3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one

595-33-5

Megestrol acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: CrO3; pyridine
2: aqueous HCl
3: acetic acid; toluene-4-sulfonic acid
4: tetrachloro-<1,4>benzoquinone
View Scheme

Megestrol acetate Chemical Properties

Name:17-Acetyloxy-6-methylpregna-4,6-diene-3,20-dione
Other names:Megestrol acetate;6-diene-3,20-dione;17-hydroxy-6-methyl-pregna-acetate;17- (acetyloxy)-6-methylpregna-4 ,6-dien-3,20-dione;17-acetoxy-6-methylpregna-4, 6-dien-3;20-dione;megestrol acetate acetate; 17α-acetoxy-6-methyl-pregn-4 ,6-diene-;6-methyl-pregn-4 ,6-dien-17 alpha-ol ,20 - dione-17-acetate
17α-hydroxy-6-methyl-;16-4,6-diene; 20-dione-17-acetate
Molecular formula : C24H32O4
MW : 384.52
refractive index: 11°C (C=2, CHCl3)
Melting point:214-216 °C
ACD/LogP(pH 5.5): 3.82
ACD/LogP(pH 5.5): 3.82
ACDXLogP: 3.90 

nature : a white or slightly yellow crystalline powder in methanol, tasteless, odorless.Soluble acetone, ethanol-soluble, ether, do not dissolve in water.

Megestrol acetate Uses

Efficacy of medroxyprogesterone acetate (MPA) intermediates

Megestrol acetate Production

available 16-17α-dione by the open-loop hydrogen bromide and nickel Catalytic Reduction of bromine, in the production of 17 alpha-hydroxy progesterone, and then acetylated and acid hydrolysis of the production of 17 alpha-acetoxy progesterone, and then to the original three formic acid and ethyl ether of Vilsmeier reacted 3-ethoxy-6-formyl-17α- acetoxy ,16 ,5-diene-20-one, and the final KBH4, acid hydrolysis, dehydration and transposition of the goods obtained.

Megestrol acetate Toxicity Data With Reference

1.   

dns-mus-scu 200 mg/kg

   JOENAK    Journal of Endocrinology. 60 (1974),167.
2.   

dni-mus-scu 200 mg/kg

   JOENAK    Journal of Endocrinology. 60 (1974),167.
3.   

ivn-mus LD50:56 mg/kg

   CSLNX*    U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#00931 .

Megestrol acetate Consensus Reports

IARC Cancer Review: Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 ,1979,p. 431.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

Megestrol acetate Safety Profile

Suspected carcinogen with experimental carcinogenic and teratogenic data. Poison by intravenous route. Human reproductive effects by ingestion and implant routes: effects on ovaries and fallopian tubes, menstrual cycle changes, and female fertility index changes. Mutation data reported. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. An FDA proprietary drug used to treat endometriosis and breast cancer. A steroid.

Megestrol acetate Standards and Recommendations

Megestrol Acetate, Micronized, USP, 97.0-103.0%
Megestrol Acetate, 99% 
Megestrol acetate, 98% 
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 595-33-5