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Meldrum's acid

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Name

Meldrum's acid

EINECS 217-992-8
CAS No. 2033-24-1 Density 1.201 g/cm3
Solubility 2.5 g/100 mL (20 °C) in water Melting Point 92-96 °C(lit.)
Formula C6H8O4 Boiling Point 356.7 °C at 760 mmHg
Molecular Weight 144.13 Flash Point 195.1 °C
Transport Information Appearance white to beige crystals
Safety 37/39-24/25-53-45-36-26 Risk Codes 36/37/38-45
Molecular Structure Molecular Structure of 2033-24-1 (2,2-Dimethyl-1,3-dioxane-4,6-dione) Hazard Symbols IrritantXi, ToxicT
Synonyms

2,2-Dimethyl-1,3-dioxan-4,6-dione;2,2-Dimethyl-4,6-dioxo-1,3-dioxane;2,2-Dimethyl-m-dioxane-4,6-dione;2,2-Propanediol cyclic malonate;Cyclic isopropylidene malonate;Isopropylidenemalonate;Meldrumic acid;

 

Consensus Reports

Reported in EPA TSCA Inventory.

Standards and Recommendations

ASSAY: 98.0% min
LOSS ON DRYING: 0.5% max

Specification

Meldrum's acid , its cas register number is 2033-24-1. It also can be called 2,2-Dimethyl-1,3-dioxane-4,6-dione; 2,2-Dimethyl-4,6-dioxo-m-dioxane; 2,2-Dimethyl-m-dioxane-4,6-dione; Isopropylidene malonate; m-Dioxane-4,6-dione, 2,2-dimethyl-; 1,3-Dioxane-4,6-dione, 2,2-dimethyl- ; Malonic acid, cyclic isopropylidene ester (8CI). It is a brown white solid. Meldrum's acid  is an intermediate for different organic syntheses. It is an important intermediate in syntheses of vitamins B1 and B6, barbiturate, non-steroidal anti-inflammatory agent, other numerous pharmaceutical, agrochemical and flavor & fragrance compound. As an alternative to its original preparation, Meldrum's acid can be synthesized from malonic acid, isopropenyl acetate, and catalytic sulfuric acid.

Physical properties about Meldrum's acid are: (1)ACD/LogP: -1.579; (2)ACD/LogD (pH 5.5): -1.58; (3)ACD/LogD (pH 7.4): -1.58; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 3.30; (7)ACD/KOC (pH 7.4): 3.30; (8)#H bond acceptors: 4; (9)Index of Refraction: 1.434; (10)Molar Refractivity: 31.24 cm3; (11)Molar Volume: 119.95 cm3; (12)Polarizability: 12.384 10-24cm3; (13)Surface Tension: 33.2239990234375 dyne/cm; (14)Density: 1.202 g/cm3; (15)Flash Point: 195.118 °C; (16)Enthalpy of Vaporization: 60.204 kJ/mol; (17)Boiling Point: 356.749 °C at 760 mmHg

When you are using Meldrum's acid, please be cautious about it as the following:
1. Wear suitable gloves and eye/face protection;
2. Avoid contact with skin and eyes;
3. Avoid exposure - obtain special instruction before use;
4. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
5. Wear suitable protective clothing;
6. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C6H8O4/c1-6(2)9-4(7)3-5(8)10-6/h3H2,1-2H3;
(2)InChIKey=GXHFUVWIGNLZSC-UHFFFAOYSA-N;
(3)SmilesC1(OC(CC(O1)=O)=O)(C)C;

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04102,

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