Basic information
- Name:
Menadione
- CAS No.:
58-27-5
- Molecular Structure:
- Formula:
- C11H8O2
- Molecular Weight:
- 172.18 .
- Synonyms:
- 1,4-Naphthalenedione,2-methyl-;2-Methyl-1,4-naphthalenedione;Kipca;VK3;Karcon;Kayklot;Kanone;Kayquinone;Memodol;Menaquinone 0;Kappaxin;Aquakay;2-Methylnaphthoquinone;Menadionum;Klottone;Kappaxin (TN);3-Methyl-1,4-naphthoquinone;K-Thrombyl;2-Methyl-1,4-naphthochinon [German];Synkay;Methyl-1,4-naphthoquinone;Methyl-1,4-naphthalenedione;Usaf ek-5185;Kappaxan (VAN);Mitenone;2-Methyl-1,4-naftochinon [Czech];Prestwick_313;Menadion;2-Methyl-1,4-naphthochinon;Vitamin K3;1,4-Naphthoquinone, 2-methyl-;Juva-K;1,4-Naphthalenedione, 2-methyl-;Riboflavin (Vitamin B2);Kolklot;Vitamin K2 (0);Hemodal;1, 4-Naphthoquinone, 2-methyl-;Koaxin;Menaphthone;Kaykot;Menaphthon;MNQ;Kaergona;2-methyl-1,4-dihydronaphthalene-1,4-dione;
- EINECS:
- 200-372-6
- Density:
- 1.225 g/cm3
- Melting Point:
- 105-107 °C(lit.)
- Boiling Point:
- 304.5 °C at 760 mmHg
- Flash Point:
- 113.8 °C
- Solubility:
- insoluble in water
- Appearance:
- bright yellow crystals
- Hazard Symbols:
Xn,
Xi- Risk Codes:
- 22-36/37/38-43
- Safety Description:
- 26-36-37/39-24 Details
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Chemistry
IUPAC Name: 2-methylnaphthalene-1,4-dione
Empirical Formula: C11H8O2
Molecular Weight: 172.18g/mol
EINECS: 200-372-6
Structure of Menadione (CAS NO.58-27-5):
Index of Refraction: 1.592
Molar Refractivity: 47.6 cm3
Molar Volume: 140.5 cm3
Polarizability: 18.87×10-24cm3
Surface Tension: 46.4 dyne/cm
Density: 1.225 g/cm3
Flash Point: 113.8 °C
Enthalpy of Vaporization: 54.49 kJ/mol
Melting Point: 105-107 °C(lit.)
Boiling Point: 304.5 °C at 760 mmHg
Vapour Pressure: 0.000871 mmHg at 25°C
Solubility: oil: soluble
Form: crystalline
Color: yellow
Water Solubility: INSOLUBLE
Sensitive: Light Sensitive
Stability: Stable. May be light sensitive. Incompatible with strong oxidizing agents.
Product Categories: Biochemistry;Vitamins;Nutritional fortification substances;Vitamins and derivatives;Vitamin Ingredients;Miscellaneous Compounds
Canonical SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O
InChI: InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChIKey: MJVAVZPDRWSRRC-UHFFFAOYSA-N
Uses
Menadione (CAS NO.58-27-5) is used as a source of vitamin K in the treatment of hypoprothrombinemia against vitamin K deficiency.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| chicken | LDLo | intraperitoneal | 100mg/kg (100mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 125, 1940. | |
| mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | National Technical Information Service. Vol. AD691-490, | |
| mouse | LD50 | oral | 500mg/kg (500mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 125, 1940. | |
| mouse | LD50 | subcutaneous | 138mg/kg (138mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 111, 1942. | |
| rabbit | LDLo | oral | 230mg/kg (230mg/kg) | VASCULAR: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 111, 1942. |
| rat | LD50 | intraperitoneal | 75mg/kg (75mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes: 
Xn,
Xi
Risk Statements: 22-36/37/38-43
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R43:May cause sensitization by skin contact.
Safety Statements: 26-36-37/39-24
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
S24:Avoid contact with skin.
WGK Germany: 3
RTECS: QL9100000
F: 8
Poison by ingestion, intraperitoneal, and subcutaneous routes. Experimental teratogenic effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Standards and Recommendations
IDENTIFICATION: Conforms
ASSAY: 98.5 - 101.5%
RESIDUE ON IGNITION: 0.1% max
LOSS ON DRYING: 0.5% max
HEAVY METALS: 20ppm max
Specification
Menadione , its cas register number is 58-27-5. It also can be called 1,4-Naphthalenedione, 2-methyl- ; 2-Methyl-1,4-naphthochinon ; 2-Methylnaphthoquinone ; 3-Methyl-1,4-naphthoquinone ; Aquakay ; Aquinone ; Kayquinone ; Kipca ;
Kipca-oil soluble ; Memodol ; Menaquinone ; Mitenon ; Mitenone ; Panosine ; Thyloquinone ; Vitamin K3 . Menadione (CAS NO.58-27-5) is a bright yellow crystals.