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Mercury chloride

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Name

Mercury chloride

EINECS 231-299-8
CAS No. 7487-94-7 Density 5.44
PSA 0.00000 LogP 1.37650
Solubility soluble in water Melting Point 277 °C(lit.)
Formula Cl2Hg Boiling Point 302 °C
Molecular Weight 271.496 Flash Point 302°C
Transport Information UN 1624 6.1/PG 2 Appearance white crystalline powder
Safety 36/37/39-45-60-61 Risk Codes 28-34-48/24/25-50/53
Molecular Structure Molecular Structure of 7487-94-7 (Mercury(II) chloride) Hazard Symbols VeryT+; DangerousN
Synonyms

Bichloride of mercury;Chlorid rtutnaty;

 

Mercury chloride Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 58 ,1993,p. 239.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 58 ,1993,p. 239.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 58 ,1993,p. 239.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Mercury and its compounds are on the Community Right-To-Know List. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.

Mercury chloride Standards and Recommendations

OSHA PEL: CL 0.1 mg(Hg)/m3 (skin)
ACGIH TLV: TWA 0.1 mg(Hg)/m3 (skin); BEI: 35 μg/g creatinine total inorganic mercury in urine preshift; 15 μg/g creatinine total inorganic mercury in blood at end of shift at end of workweek.
NIOSH REL: (Mercury, Aryl and Inorganic) CL 0.1 mg/m3 (skin)
DOT Classification:  6.1; Label: Poison

Mercury chloride Specification

The Mercury(II) chloride, with the CAS registry number 7487-94-7 and EINECS registry number 231-299-8, is a kind of white crystals. And the molecular formula of this chemical is Cl2Hg. It is sensitive to moisture, and will decompose by sunlight. What's more, it is soluble in water, and can be stored at room temperature.

The physical properties of Mercury(II) chloride are as following: (1)ACD/LogP: 0.00; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0; (4)ACD/LogD (pH 7.4): 0; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)#H bond acceptors: 0; (8)#H bond donors: 0; (9)#Freely Rotating Bonds: 0; (10)Polar Surface Area: 0 Å2; (11)Enthalpy of Vaporization: 16.15 kJ/mol; (12)Boiling Point: °C at 760 mmHg; (13)Vapour Pressure: 33900 mmHg at 25°C.

Preparation of Mercury(II) chloride: It can be obtained by the action of chlorine on mercury or mercury(I) chloride, by the addition of hydrochloric acid to a hot, concentrated solution of mercury(I) compounds such as the nitrate:
HgNO3 + 2 HCl → HgCl2 + H2O + NO2

Uses of Mercury(II) chloride: It was used in photography, preservation. It was also used in medicine, but because is highly toxic, it is no longer used for medicinal purposes. It is often used as a chemical reagent. What's more, the main application of mercuric chloride is as a catalyst for the conversion of acetylene to vinyl chloride, the precursor to polyvinylchloride:
C2H2 + HCl → CH2=CHCl

You should be cautious while dealing with this chemical. It is toxic to aquatic organisms, and may cause long-term adverse effects in the aquatic environment. It also has danger of serious damage to health by prolonged exposure in contact with skin and if swallowed. What's more, it may cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of accident or if you feel unwell, seek medical advice immediately (show label where possible); This material and/or its container must be disposed of as hazardous waste; Avoid release to the environment. Refer to special instructions safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl[Hg]Cl
(2)InChI: InChI=1/2ClH.Hg/h2*1H;/q;;+2/p-2
(3)InChIKey: LWJROJCJINYWOX-NUQVWONBAW

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 2710ug/kg (2.71mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 423, 1932.
dog LDLo oral 10mg/kg (10mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
frog LD50 intramuscular 7579ug/kg (7.579mg/kg)   Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. Vol. 85, Pg. 253, 1986.
frog LD50 intramuscular 7579ug/kg (7.579mg/kg)   Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. Vol. 85, Pg. 253, 1986.
frog LD50 intramuscular 7579ug/kg (7.579mg/kg)   Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. Vol. 85, Pg. 253, 1986.
frog LDLo oral 2424mg/kg (2424mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
frog LDLo subcutaneous 2gm/kg (2000mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
guinea pig LDLo intraperitoneal 345mg/kg (345mg/kg)   Archives of Environmental Health. Vol. 11, Pg. 201, 1965.
guinea pig LDLo skin 345mg/kg (345mg/kg)   Archives of Environmental Health. Vol. 11, Pg. 201, 1965.
human LDLo oral 29mg/kg (29mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE

GASTROINTESTINAL: NAUSEA OR VOMITING
New England Journal of Medicine. Vol. 244, Pg. 459, 1951.
man LDLo oral 14286ug/kg (14.286mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

GASTROINTESTINAL: NAUSEA OR VOMITING
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 41, Pg. 2383, 1999.
man LDLo oral 86mg/kg (86mg/kg) VASCULAR: CHANGE IN PLASMA OR BLOOD VALUME

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: NECROTIC GHANGES
Journal of Toxicology, Clinical Toxicology. Vol. 26, Pg. 189, 1988.
man LDLo oral 143mg/kg (143mg/kg) BEHAVIORAL: EXCITEMENT

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Igaku to Seibutsugaku. Medicine and Biology. Vol. 2, Pg. 48, 1942.
man LDLo unreported 7253ug/kg (7.253mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 21mg/kg (21mg/kg) GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Clinical Toxicology. Vol. 11, Pg. 309, 1977.
man TDLo oral 29mg/kg (29mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Medical Journal of Australia. Vol. 2, Pg. 125, 1978.
man TDLo oral 57mg/kg (57mg/kg) GASTROINTESTINAL: GASTRITIS

LIVER: LIVER FUNCTION TESTS IMPAIRED

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Japanese Journal of Toxicology. Vol. 8, Pg. 157, 1995.
mouse LCLo inhalation 300mg/m3/10M (300mg/m3)   National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. No.9-4-1-9, Pg. 1943,
mouse LD50 intraperitoneal 3900ug/kg (3.9mg/kg)   Pharmaceutical Chemistry Journal Vol. 25, Pg. 891, 1991.
mouse LD50 intravenous 4992ug/kg (4.992mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 21, Pg. 364, 1948.
mouse LD50 oral 6mg/kg (6mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(1), Pg. 76, 1986.
mouse LD50 subcutaneous 4500ug/kg (4.5mg/kg)   Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 34, Pg. 193, 1979.
pigeon LDLo oral 2200mg/kg (2200mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1389, 1935.
pigeon LDLo subcutaneous 1100mg/kg (1100mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1389, 1935.
quail LD50 intramuscular 34mg/kg (34mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Journal of Toxicology and Environmental Health. Vol. 20, Pg. 105, 1987.
quail LD50 oral 36mg/kg (36mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Journal of Toxicology and Environmental Health. Vol. 20, Pg. 105, 1987.
rabbit LD50 intramuscular 7300ug/kg (7.3mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 119, 1946.
rabbit LDLo intravenous 2mg/kg (2mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 35, Pg. 343, 1929.
rabbit LDLo oral 20mg/kg (20mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LDLo subcutaneous 10mg/kg (10mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rat LD50 intraperitoneal 3210ug/kg (3.21mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Proceedings of the European Society for the Study of Drug Toxicity. Vol. 12, Pg. 247, 1971.
rat LD50 intravenous 1272ug/kg (1.272mg/kg)   Archives of Toxicology. Vol. 58, Pg. 243, 1986.
rat LD50 oral 1mg/kg (1mg/kg)   Pesticide Manual. Vol. 9, Pg. 550, 1991.
rat LD50 skin 41mg/kg (41mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(7), Pg. 27, 1981.
rat LD50 subcutaneous 14mg/kg (14mg/kg)   Japanese Journal of Experimental Medicine. Vol. 39, Pg. 47, 1969.
women TDLo oral 18mg/kg (18mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

BLOOD: OTHER CHANGES
Human & Experimental Toxicology. Vol. 11, Pg. 53, 1992.
women TDLo oral 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
American Journal of Obstetrics and Gynecology. Vol. 80, Pg. 145, 1960.