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Metenolone

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Name

Metenolone

EINECS 205-812-0
CAS No. 153-00-4 Density 1.084 g/cm3
PSA 37.30000 LogP 4.12520
Solubility N/A Melting Point 126-129°C(lit.)
Formula C20H30O2 Boiling Point 430.381 °C at 760 mmHg
Molecular Weight 302.457 Flash Point 183.597 °C
Transport Information N/A Appearance N/A
Safety Risk Codes R34
Molecular Structure Molecular Structure of 153-00-4 (Metenolone) Hazard Symbols C
Synonyms

5α-Androst-1-en-3-one, 17β-hydroxy-1-methyl- (6CI,7CI,8CI);1-Methyl-5α-androst-1-en-17β-ol-3-one;1-Methyl-D1-androsten-17β-ol-3-one;17β-Hydroxy-1-methyl-5α-androst-1-en-3-one;Methenolon;Androst-1-en-3-one,17-hydroxy-1-methyl-, (5α,17β)-;

Article Data 6

Metenolone Synthetic route

4360-33-2

3-Aethylendioxy-1-methylen-5α-androstanol-(17β)

153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

Conditions
ConditionsYield
(i) Zn-Cu, I2, CH2I2, Et2O, (ii) aq. H2SO4, MeOH; Multistep reaction;

methenolone enanthate

A

153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

B

12β,17β-dihydroxy-1-methyl-5α-androstan-1-ene-3-one

C

16β,17β-dihydroxy-1-methyl-5α-androstan-1-ene-3-one

D

17β-hydroxy-1-methyl-5α-androstan-1-ene-3,16-dione

E

15β,17β-dihydroxy-1-methyl-5α-androstan-1-ene-3-one

F

1424-01-7

1-methyl-5α-androst-1-ene-3,17-dione

Conditions
ConditionsYield
With Aspergillus niger In methanol at 26℃; for 288h; Microbiological reaction;

methenolone enanthate

153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

Conditions
ConditionsYield
With Cunninghamella blakesleeana In methanol at 26℃; for 288h; Microbiological reaction;
153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

18162-48-6

tert-butyldimethylsilyl chloride

127557-35-1

17β-(tert.-butyldimethylsilyloxy)-1-methyl-5α-androsta-1-en-3-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 24h; Ambient temperature;96%
153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

96301-34-7

atamestane

Conditions
ConditionsYield
With diphenyl diselenide; iodosylbenzene In toluene at 80℃; for 9h;51%
153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

2616-64-0

UDP-glucuronic acid

A

1-methyl-5α-androst-1-1en-3-one-17β-O-glucuronide

B

3α-hydroxy-1-methylen-5α-androstan-17-one glucuronide

Conditions
ConditionsYield
With liver microsomes from Aroclor 1254-induced male Wistar rat In methanol; phosphate buffer at 37℃; pH=7.4;A 24%
B 28%
153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

A

1232-57-1

1β-Methyl-4,5α-dihydro-testosteron (17β-Hydroxy-1β-methyl-5α-androstan-3-on)

B

1424-00-6

mesterolone

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tributylzinc hydride In tetrahydrofuran for 1h; Heating; Yield given. Yields of byproduct given;
153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

38631-89-9

(1S,5R,8R,9S,10S,13S,14S,17S)-1,10,13-Trimethyl-17-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Tributylzinnhydrid, Azobisisobutyronitril / tetrahydrofuran / 1 h / Heating
2: hexamethyldisilazane / pyridine / 0.25 h
View Scheme
153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

38631-89-9

(1S,5S,8R,9S,10S,13S,14S,17S)-1,10,13-Trimethyl-17-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Tributylzinnhydrid, Azobisisobutyronitril / tetrahydrofuran / 1 h / Heating
2: hexamethyldisilazane / pyridine / 0.25 h
View Scheme
153-00-4

17β-hydroxy-1-methyl-5α-androst-1-en-3-one

127557-29-3

1,4-dimethylandrosta-1,4-dien-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 96 percent / imidazole / dimethylformamide / 24 h / Ambient temperature
2: 1.) lithium diisopropylamide / 1.) THF, 0 deg, 15 min; 2.) THF, -78 deg C, 3 h; 3.) THF, -78 deg C, 15 min; 4.) r.t., 30 min
3: 87 percent / acetic acid / tetrahydrofuran; H2O / 72 h / 50 - 60 °C
4: 95 percent / dimethylaminopyridine / pyridine / 4 h / Ambient temperature
5: 31 percent / iodoxybenzene, diphenyl diselenide / toluene / 7 h / 80 °C
6: 92 percent / 3 percent potassium hydroxide / methanol / 4 h / Ambient temperature
7: 83 percent / chromium trioxide, conc. sulfuric acid / H2O; acetone / 0.25 h / Ambient temperature
View Scheme

Metenolone Specification

1. Introduction of Methenolone
Methenolone is one kind of white or almost white crystalline powder. The IUPAC Name of this chemical is (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-1,10,13-trimethyl-4,5,6,7,8,9,11,
12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one. Besides, Methenolone belongs to Steroids; Steroid and Hormone; Finished Steroid and Hormone. What's more, its systematic name is (5α,17β)-17-Hydroxy-1-methylandrost-1-en-3-one. Its classification codes are: (1)Anabolic Agents; (2)Hormones; (3)Hormones, Hormone Substitutes, and Hormone Antagonists.

This chemical is a synthetic steroid that has been used for its anabolic action. It is supplied as the acetate ester for oral administration and as the enanthate ester for intramuscular injection.

2. Properties of Methenolone
Physical properties about Methenolone are:
(1)ACD/LogP: 3.717; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.72; (4)ACD/LogD (pH 7.4): 3.72; (5)ACD/BCF (pH 5.5): 393.28; (6)ACD/BCF (pH 7.4): 393.28; (7)ACD/KOC (pH 5.5): 2505.49; (8)ACD/KOC (pH 7.4): 2505.49; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 37.3 Å2; (13)Index of Refraction: 1.542; (14)Molar Refractivity: 87.803 cm3; (15)Molar Volume: 278.897 cm3; (16)Polarizability: 34.808×10-24cm3; (17)Surface Tension: 40.06 dyne/cm; (18)Density: 1.084 g/cm3; (19)Flash Point: 183.597 °C; (20)Enthalpy of Vaporization: 79.187 kJ/mol; (21)Boiling Point: 430.381 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

3. Structure Descriptors of Methenolone
You can still convert the following datas into molecular structure:
(1)SMILES: O=C2\C=C(\C)[C@@]3([C@H]1CC[C@@]4([C@@H](O)CC[C@H]4[C@@H]1CC[C@H]3C2)C)C
(2)Std. InChI: InChI=1S/C20H30O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h10,13,15-18,22H,4-9,11H2,1-3H3/t13-,15-,16-,17-,18-,19-,20-/m0/s1
(3)Std. InChIKey: ANJQEDFWRSLVBR-VHUDCFPWSA-N
(4)Canonical SMILES : CC1=CC(=O)CC2C1(C3CCC4(C(C3CC2)CCC4O)C)C
(5)Isomeric SMILES: CC1=CC(=O)C[C@H]2[C@]1([C@H]3CC[C@]4([C@H]([C@@H]3CC2)CC[C@@H]4O)C)C

4. Physical Properties of Methenolone

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.690 (none)   EST
Atmospheric OH Rate Constant 1.15E-10 cm3/molecule-sec 25 EST

5. Uses of Methenolone
Methenolone can be used to produce 1-methylandrosta-1,4-dien-3,17-dione at the temperature of 80 °C. It will need reagents iodoxybenzene, diphenyl diselenide and solvent toluene with the reaction time of 9 hours. The yield is about 51%.
 

Methenolone can be used to produce 1-methylandrosta-1,4-dien-3,17-dione at the temperature of 80 °C

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