- Methdilazine
- Methdilazine hydrochloride
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| Name |
Methdilazine hydrochloride |
EINECS | N/A |
| CAS No. | 1229-35-2 | Density | g/cm3 |
| PSA | 31.78000 | LogP | 5.04590 |
| Solubility | N/A | Melting Point |
187.5-189° |
| Formula | C18H20 N2 S . Cl H | Boiling Point | 430.4°Cat760mmHg |
| Molecular Weight | 332.92 | Flash Point | 214.1°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. Experimental reproductive effects. An antihistamine. When heated to decomposition it emits very toxic fumes of NOx and HCl. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
10H-Phenothiazine,10-[(1-methyl-3-pyrrolidinyl)methyl]-, monohydrochloride (9CI); Phenothiazine,10-[(1-methyl-3-pyrrolidinyl)methyl]-, monohydrochloride (8CI); Dilosyn;Disyncran; Methdilazine hydrochloride; Methdilazine monohydrochloride; NSC169091; Tacaryl; Tacaryl hydrochloride |
Methdilazine hydrochloride Chemical Properties
IUPAC Name: 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride
Synonyms: 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine hydrochloride (1:1) ; 10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine hydrochloride ; 10-[(1-Methylpyrrolidin-3-yl)methyl]-10H-phenothiazine hydrochloride ; 10-[(1-Methylpyrrolidin-3-yl)methyl]-10H-phenothiazine hydrochloride (1:1) ; 10H-Phenothiazine, 10-[(1-Methyl-3-pyrrolidinyl)methyl]-, hydrochloride (1:1)
CAS NO: 1229-35-2
Molecular Formula of Methdilazine hydrochloride (CAS NO.1229-35-2) : C18H21ClN2S
Molecular Weight of Methdilazine hydrochloride (CAS NO.1229-35-2) : 332.89074
Molecular Structure of Methdilazine hydrochloride (CAS NO.1229-35-2) : 
EINECS: 214-967-3
Mol File: 1229-35-2.mol
Flash Point: 214.1 °C
Enthalpy of Vaporization: 68.58 kJ/mol
Boiling Point: 430.4 °C at 760 mmHg
Vapour Pressure: 1.3E-07 mmHg at 25°C
General Description White microcrystalline powder with a slight odor. pH (1% aqueous solution) 4.8-6.
Air & Water Reactions: Water soluble. pH (1% aqueous solution) 4.8-6 .
Methdilazine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 25mg/kg (25mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960. |
| guinea pig | LD50 | oral | 263mg/kg (263mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960. | |
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960. |
| mouse | LD50 | oral | 190mg/kg (190mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960. |
| mouse | LDLo | intramuscular | 300mg/kg (300mg/kg) | Therapie. Vol. 15, Pg. 1064, 1960. | |
| mouse | LDLo | intravenous | 25mg/kg (25mg/kg) | Therapie. Vol. 15, Pg. 1064, 1960. | |
| rabbit | LD50 | intravenous | 17mg/kg (17mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960. |
| rat | LD50 | oral | 260mg/kg (260mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960. |
| rat | LDLo | intraperitoneal | 75mg/kg (75mg/kg) | Therapie. Vol. 15, Pg. 1064, 1960. | |
| rat | LDLo | intravenous | 22mg/kg (22mg/kg) | Therapie. Vol. 15, Pg. 1064, 1960. |
Methdilazine hydrochloride Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. Experimental reproductive effects. An antihistamine. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Methdilazine hydrochloride Specification
Reactivity Profile: Methdilazine hydrochloride (200 MG) is sensitive to exposure to light. An acidic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
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