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Methohexital Sodium

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Name

Methohexital Sodium

EINECS 206-217-9
CAS No. 309-36-4 Density g/cm3
PSA 57.69000 LogP 1.35910
Solubility N/A Melting Point N/A
Formula C14H18 N2 O3 . Na Boiling Point 382.1°Cat760mmHg
Molecular Weight 284.32 Flash Point 184.9°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous and implant routes. Human systemic effects by intravenous route: blood pressure lowering, gastrointestinal effects, and allergic dermatitis. An FDA proprietary drug. Caution: Excessive use may lead to addiction or habituation. Allergenic effects by intravenous route. When heated to decomposition it emits toxic fumes of Na2O and NOx. See also BARBITURATES. Risk Codes N/A
Molecular Structure Molecular Structure of 309-36-4 (Methohexital Sodium) Hazard Symbols N/A
Synonyms

2,4,6(1H,3H,5H)-Pyrimidinetrione,1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, sodium salt (9CI);Barbituricacid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-, sodium deriv. (6CI,7CI);Barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-, sodium salt (8CI);Brevimytal;Brevimytal sodium;Brevital sodium;Brietal sodium;Enallynymalsodium;Methohexitone sodium;Sodium methohexital;Sodiummethohexitone;2,4,6(1H,3H,5H)-Pyrimidinetrione,1-methyl-5-(1-methyl-2-pentyn-1-yl)-5-(2-propen-1-yl)-, sodium salt (1:1);

 

Methohexital Sodium Chemical Properties

The IUPAC name of Methohexital Sodium (CAS NO.309-36-4):
Sodium 5-hex-3-yn-2-yl-1-methyl-4,6-dioxo-5-prop-2-enylpyrimidin-2-olate
Synonyms: Methohexital sodium ; Brevimytal .;Sodiummethohexital ; Methohexitone sodium ; Brevital sodium ; Enallynymal sodium
CAS: 309-36-4 
EINECS: 206-217-9 
Molecular Formula: C14H18N2O3Na 
Molecular Structure:

Molecular Weight: 284.2861 g/mol
Flash Point: 184.9 °C 
Boiling Point: 382.1 °C at 760 mmHg
General Description: White powder.
Air & Water Reactions: Water soluble. 

Methohexital Sodium Uses

Methohexital is primarily used to induce anesthesia, and is generally provided as a sodium salt (i.e. methohexital sodium). It is only used in hospital or similar settings, under strict supervision.[citation needed] It has been commonly used to induce deep sedation, "twilight sleep" or general anesthesia for oral surgery and dentistry. It is also used to induce anesthesia prior to ECT(electroconvulsive therapy).

Methohexital Sodium Toxicity Data With Reference

The toxicity of Methohexital Sodium (CAS NO.309-36-4): 

1.    

ivn-wmn TDLo:25 µg/kg:CVS,GIT,SKN

    JOSUA9    Journal of Oral Surgery. 30 (1972),906.
2.    

ivn-rat LD50:24,890 µg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292.
3.    

imp-rat LD50:33 mg/kg

    29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75.
4.    

ivn-mus LD50:33,600 µg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 12 (1976),247.
5.    

ivn-dog LD50:21,500 µg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292.
6.    

imp-dog LD50:25 mg/kg

    29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75.
7.    

ivn-rbt LD50:8640 µg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292.
8.    

imp-rbt LD50:10 mg/kg

    29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75.

Methohexital Sodium Safety Profile

The Fire Hazard of Methohexital Sodium (CAS NO.309-36-4): Flash point data are not available for methohexital sodium, but methohexital sodium is probably combustible. Poison by intravenous and implant routes. Human systemic effects by intravenous route: blood pressure lowering, gastrointestinal effects, and allergic dermatitis. An FDA proprietary drug. Caution: Excessive use may lead to addiction or habituation. Allergenic effects by intravenous route. When heated to decomposition it emits toxic fumes of Na2O and NOx. See also BARBITURATES.

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