- Methyl (2-chloromethyl)oxazole-4-carboxylate
- Methyl (2R)-2-bromo-2-(2-chlorophenyl)acetate
- Methyl (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylate
- Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate
- Methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate
- Methyl (2S)-1-(1,2-dioxo-3,3-dimethypentyl)-2-pyrrolidinecarboxylate
- Methyl (2S)-2,3-epoxypropanoate
- Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoate
- Methyl (2S)-2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate
- Methyl (2S)-2-amino-2-cyclopentyl-acetate hydrochloride
- 624-84-0Hydrazinecarboxaldehyde
- 62484-16-62,4(1H,3H)-Quinazolinedione,6-methyl-
- 62484-29-12,4,8-trichloroquinazoline
- 62484-31-52,4-Dichloro-7-methoxyquinazoline
- 62-48-62-Sulfanyl-N'-(sulfanylacetyl)acetohydrazide
- 62488-56-62,4-Nonadien-1-ol
- 624-89-5Ethane, (methylthio)-
- 624-91-9Nitrous acid, methylester
- 624-92-0Dimethyl disulfide
- 62494-12-6Ukrinol 1 (9CI)
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
| Name |
Methyl isocyanate |
EINECS | 210-866-3 | |
| CAS No. | 624-83-9 | Density | 0.88 g/cm3 | |
| PSA | 29.43000 | LogP | -0.04800 | |
| Solubility | reacts | Melting Point |
-80 ºC |
|
| Formula | C2H3 N O | Boiling Point | 39 ºC | |
| Molecular Weight | 57.0519 | Flash Point | -18 ºC | |
| Transport Information | N/A | Appearance | colourless liquid | |
| Safety | Poison by inhalation, ingestion, and skin contact. Human systemic effects by inhalation: conjunctiva irritation, olfactory and pulmonary changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A severe eye, skin, and mucous membrane irritant and a sensitizer. It can be absorbed through the skin. Exposure to high concentrations of the vapor can cause blindness; lung damage, including edema, permanent fibrosis, emphysema, and bronchitis; and gynecological effects. Most deaths are a result of lung tissue damage. This was the predominant cause of death in the release of MIC in 1984 at Bhopal, India. Effects of cyanide poisoning have been noted but this may be due to impurities. A flammable liquid and a very dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use spray, foam, CO2, dry chemical. Exothermic reaction with water. When heated to decomposition it emits toxic fumes of NOx and CN−. See also ISOCYANATES. | |||
Analytical Methods: | For occupational chemical analysis use OSHA: #54. |
Risk Codes | 12-24/25-26-37/38-41-42/43-63 | |
| Molecular Structure |
|
Hazard Symbols | Flammable, dangerous fire risk. Toxic by skin absorption and a strong irritant. TLV: 0.02 ppm. | |
| Synonyms |
Isocyanicacid, methyl ester (6CI,8CI); Isocyanatomethane; MIC; Methyl isocyanate; NSC64323 |
Article Data | 146 |
Methyl isocyanate Chemical Properties
IUPAC: Methylimino(oxo)methane
Methyl isocyanate (624-83-9) is also called for 4-04-00-00247 (Beilstein Handbook Reference) ; AI3-28280 ; BRN 0605318 ; CCRIS 1385 ; EINECS 210-866-3 ; HSDB 1165 ; Iso-cyanatomethane ; Isocyanate de methyle ; Isocyanate, methyl- ; Isocyanic acid, methyl ester ; Methane, isocyanato- ; Methyl carbonimide ; Methyl isocyanat ; Methyl isocyanate ; Methyl isocyanide ; Methylcarbylamine ; Methylisocyanaat ; Metil isocianato ; NSC 64323 ; RCRA waste number P064 ; TL 1450 ; UN 2480 ; RCRA waste no. P064 and so on.
Molecular Formula: C2H3NO
Molecular Weight: 57.05
LogP: ACD/LogP: 0.83
XLogP: 1.60
ACD/LogD (pH 5.5): 0.83
ACD/LogD (pH 7.4): 0.83
ACD/BCF (pH 5.5): 2.52
ACD/BCF (pH 7.4): 2.52
ACD/KOC (pH 5.5): 67.37
ACD/KOC (pH 7.4): 67.37
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Index of Refraction: 1.393
Molar Refractivity: 15.47 cm3
Molar Volume: 64.7 cm3
Surface Tension: 28.3 dyne/cm
Density: 0.88 g/cm3
FEnthalpy of Vaporization: 26.84 kJ/mol
Boiling Point: 35°C at 760 mmHg
Vapour Pressure: 531 mmHg at 25°C
The molecular structure of Methyl isocyanate (624-83-9):
Methyl isocyanate Uses
Methyl isocyanate (624-83-9) is used as antisickling agents,which mean agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
Methyl isocyanate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LC50 | inhalation | 5400ppb/6H (5.4ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Fundamental and Applied Toxicology. Vol. 6, Pg. 747, 1986. |
| human | TCLo | inhalation | 2ppm (2ppm) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archiv fuer Toxikologie. Vol. 20, Pg. 235, 1964. |
| mouse | LC50 | inhalation | 12200ppb/6H (12.2ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Fundamental and Applied Toxicology. Vol. 6, Pg. 747, 1986. |
| mouse | LD50 | oral | 120mg/kg (120mg/kg) | Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977. | |
| mouse | LD50 | skin | 1820mg/kg (1820mg/kg) | Yakkyoku. Pharmacy. Vol. 38, Pg. 391, 1987. | |
| mouse | LD50 | subcutaneous | 81900ug/kg (81.9mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Indian Journal of Experimental Biology. Vol. 25, Pg. 531, 1987. |
| rabbit | LD50 | skin | 220uL/kg (0.22mL/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | National Technical Information Service. Vol. OTS0529151, |
| rabbit | LD50 | subcutaneous | 126mg/kg (126mg/kg) | Toxicology. Vol. 51, Pg. 223, 1988. | |
| rat | LC50 | inhalation | 6100ppb/6H (6.1ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Fundamental and Applied Toxicology. Vol. 6, Pg. 747, 1986. |
| rat | LD50 | oral | 51500ug/kg (51.5mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Indian Journal of Experimental Biology. Vol. 25, Pg. 531, 1987. |
| rat | LD50 | skin | 2780mg/kg (2780mg/kg) | Yakkyoku. Pharmacy. Vol. 38, Pg. 391, 1987. | |
| rat | LD50 | subcutaneous | 261mg/kg (261mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Indian Journal of Experimental Biology. Vol. 25, Pg. 531, 1987. |
Methyl isocyanate Consensus Reports
Reported in EPA TSCA Inventory.
Methyl isocyanate Safety Profile
Poison by inhalation, ingestion, and skin contact. Human systemic effects by inhalation: conjunctiva irritation, olfactory and pulmonary changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A severe eye, skin, and mucous membrane irritant and a sensitizer. It can be absorbed through the skin. Exposure to high concentrations of the vapor can cause blindness; lung damage, including edema, permanent fibrosis, emphysema, and bronchitis; and gynecological effects. Most deaths are a result of lung tissue damage. This was the predominant cause of death in the release of MIC in 1984 at Bhopal, India. Effects of cyanide poisoning have been noted but this may be due to impurities. A flammable liquid and a very dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use spray, foam, CO2, dry chemical. Exothermic reaction with water. When heated to decomposition it emits toxic fumes of NOx and CN−. See also ISOCYANATES.
Methyl isocyanate Standards and Recommendations
OSHA PEL: TWA 0.02 ppm (skin)
ACGIH TLV: TWA 0.02 ppm (skin)
DFG MAK: 0.01 ppm (0.025 mg/m3)
DOT Classification: 6.1; Label: Poison, Flammable Liquid; DOT Class: 3; Label: Flammable Liquid, Poison
Methyl isocyanate Analytical Methods
For occupational chemical analysis use OSHA: #54.
Methyl isocyanate Specification
Treatment of Methyl isocyanate (624-83-9) in Wastewater, see as follows :
Total removal: 29.33 percent
Total biodegradation: 0.07 percent
Total sludge adsorption: 1.35 percent
Total to air: 27.91 percent
(using 10000 hr Bio P,A,S)