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Methyl propyl ether

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Name

Methyl propyl ether

EINECS 209-158-7
CAS No. 557-17-5 Density 0.734 g/cm3
PSA 9.23000 LogP 1.04280
Solubility N/A Melting Point N/A
Formula C4H10 O Boiling Point 40.1 °C at 760 mmHg
Molecular Weight 74.1228 Flash Point °C
Transport Information N/A Appearance N/A
Safety 16-33 Risk Codes 11
Molecular Structure Molecular Structure of 557-17-5 (1 -Methoxypropane) Hazard Symbols N/A
Synonyms

Ether,methyl propyl (6CI,7CI,8CI); 1-Methoxypropane; Methyl n-propyl ether; Methylpropyl ether; Metopryl; Neothyl; Propyl methyl ether; a-Methoxypropane

Article Data 39

Methyl propyl ether Synthetic route

628-32-0

ethylpropylether

A

115-10-6

Dimethyl ether

B

540-67-0

ethyl methyl ether

C

557-17-5

methyl propyl ether

D

625-54-7

2-butyl ethyl ether

Conditions
ConditionsYield
Product distribution; Mechanism; Ambient temperature; Irradiation;A n/a
B 2.4%
C 4.4%
D 93.2%
628-32-0

ethylpropylether

14621-84-2

diazomethane-d2

A

115-10-6

Dimethyl ether

B

540-67-0

ethyl methyl ether

C

557-17-5

methyl propyl ether

D

625-54-7

2-butyl ethyl ether

Conditions
ConditionsYield
Product distribution; Mechanism; Ambient temperature; Irradiation; deuterium distribution;A n/a
B 3.3%
C 4.2%
D 92.5%
627-41-8

propargyl alcohol methyl ether

A

557-17-5

methyl propyl ether

B

627-40-7

methylallylether

Conditions
ConditionsYield
With hydrogen; palladium dichloride In N,N-dimethyl-formamide under 18751.5 Torr; for 0.666667h; Product distribution; Ambient temperature; various time;A 2%
B 68.4%
Stage #1: propargyl alcohol methyl ether With pyridine In toluene for 0.166667h; Glovebox;
Stage #2: With hydrogen In toluene at 120℃; under 37503.8 Torr; for 12h; Glovebox;
540-67-0

ethyl methyl ether

14621-84-2

diazomethane-d2

A

60-29-7

diethyl ether

B

598-53-8

isopropyl methyl ether

C

74-85-1

ethene

D

115-10-6

Dimethyl ether

E

557-17-5

methyl propyl ether

Conditions
ConditionsYield
Product distribution; Mechanism; Ambient temperature; Irradiation; deuterium distribution;A 29.7%
B 17.9%
C n/a
D 37.2%
E 15.2%
540-67-0

ethyl methyl ether

A

60-29-7

diethyl ether

B

598-53-8

isopropyl methyl ether

C

74-85-1

ethene

D

557-17-5

methyl propyl ether

Conditions
ConditionsYield
Product distribution; Mechanism; Ambient temperature; Irradiation;A 34%
B 33.2%
C n/a
D 32.8%

Methylethyl((trimethylsilyl)methyl)oxonium Tetrafluoroborate

A

60-29-7

diethyl ether

B

74-85-1

ethene

C

115-10-6

Dimethyl ether

D

557-17-5

methyl propyl ether

E

420-56-4

trimethylsilyl fluoride

F

usual alkylation products

usual alkylation products

Conditions
ConditionsYield
With cesium fluoride Product distribution; Mechanism;A 1.2%
B 3.9%
C 2.9%
D 0.02%
E n/a
F n/a
71-23-8

propan-1-ol

557-17-5

methyl propyl ether

67-56-1

methanol

71-23-8

propan-1-ol

557-17-5

methyl propyl ether

Conditions
ConditionsYield
With naphthalene-2-sulfonate at 122 - 126℃;
With benzenesulfonic acid at 122 - 126℃;
With naphthalene-2-sulfonate at 122 - 126℃;
With benzenesulfonic acid at 122 - 126℃;
115-10-6

Dimethyl ether

111-43-3

Dipropyl ether

557-17-5

methyl propyl ether

Conditions
ConditionsYield
With aluminum oxide; silica gel; zirconium(IV) oxide at 230℃; under 44130.5 Torr;
6819-41-6

sodium n-propoxide

74-88-4

methyl iodide

557-17-5

methyl propyl ether

Methyl propyl ether Chemical Properties

Molecule structure of Methyl propyl ether (CAS NO.557-17-5) :

IUPAC Name: 1-methoxypropane 
Molecular Weight: 74.1216 g/mol
Molecular Formula: C4H10O
Density: 0.734 g/cm3 
Boiling Point: 40.1 °C at 760 mmHg 
Index of Refraction: 1.36
Molar Refractivity: 22.32 cm3
Molar Volume: 100.9 cm3
Polarizability: 8.85×10-24 cm3
Surface Tension: 19 dyne/cm 
Enthalpy of Vaporization: 26.75 kJ/mol 
log P (octanol-water): 1.21 
Water Solubility: 3.05E+04 mg/L 
Vapor Pressure: 465 mm Hg 
Henry's Law Constant: 1.49E-03 atm-m3/mole 
Atmospheric OH Rate Constant: 1.13E-11 cm3/molecule-sec
XLogP3: 1.2
H-Bond Acceptor: 1
Rotatable Bond Count: 2
Exact Mass: 74.073165
MonoIsotopic Mass; 74.073165
Topological Polar Surface Area: 9.2
Heavy Atom Count: 5
Complexity: 13.1
Canonical SMILES: CCCOC
InChI: InChI=1S/C4H10O/c1-3-4-5-2/h3-4H2,1-2H3
InChIKey: VNKYTQGIUYNRMY-UHFFFAOYSA-N
EINECS: 209-158-7

Methyl propyl ether Uses

 Methyl propyl ether (CAS NO.557-17-5) is an ether once used as a general anaesthetic. It is also used as an alternative to diethyl ether because of its greater potency. Its use as an anaesthetic has since been supplanted by modern halogenated ethers which are much less flammable. Methyl propyl ether (CAS NO.557-17-5) also can be used as a solvent and to make other chemicals.

Methyl propyl ether Toxicity Data With Reference

1.    

ihl-mus LC50:259 mg/m3/15M

    ANESAV    Anesthesiology. 11 (1950),455.

Methyl propyl ether Safety Profile

A poison by inhalation. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating vapors.
Risk Statements: 11 
R11:Highly flammable.
Safety Statements: 16-33
S16:Keep away from sources of ignition. 
S33:Take precautionary measures against static discharges.
RIDADR: 2612
RTECS: KO2280000
HazardClass: 3.1
PackingGroup: II

Methyl propyl ether Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid

Methyl propyl ether Specification

 Methyl propyl ether (CAS NO.557-17-5) is also called 1-Methoxypropane ; Methyl n-propyl ether ; Metopryl
Neothyl ; alpha-Methoxy propane ; Propane, 1-methoxy- ; Propane, 1-methoxy- (9CI) . Methyl propyl ether (CAS NO.557-17-5) is a colorless volatile liquid with an ether-like odor. It is less dense than water and insoluble in water. Vapors heavier than air. May be narcotic by inhalation in high concentrations. Methyl propyl ether (CAS NO.557-17-5) is highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously. A mixture of liquid air and diethyl ether exploded spontaneously. Ethers, such as Methyl propyl ether (CAS NO.557-17-5) , can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution. Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated.

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